ABSTRACT
Yunnan unexplained sudden death (YUSD) has obvious spatial and temporal aggregations.With the features of sudden onset and rapid death,its causes remain unclear.However,the onset of YUSD is related to the geological and climatic conditions in specific range of altitude of incidence area,which is also influenced by the existed susceptibility gene loci or several multiple mutations in SNP loci,long-term fatigue,low dietary nutrition,trace element deficiency,poor living condition and hygienic habit,and infection by etiologic microorganism or virus among the residents live in the incidence area of YUSD.Under the continuous influence of factors above,the crowd of incidence area finally occurred unexplained sudden death that prominently shown by myocardial injury.Improvements of public health administration,living conditions,villagers' health,living habits and enhancement of indicator measurement of myocardial enzyme and electrocardiogram for the residents in the incidence area of YUSD are effective measures for prevention of YUSD.Timely identification of cause of death and in-depth genetic research are important ways to explore the causes of YUSD,enhance the effectiveness of treatment and reduce the death rate.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.</p><p><b>METHODS</b>32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.</p><p><b>RESULTS</b>Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.</p><p><b>CONCLUSION</b>Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.</p>