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1.
China Occupational Medicine ; (6): 118-120, 2021.
Article in Chinese | WPRIM | ID: wpr-881984

ABSTRACT

OBJECTIVE: To analyze the diagnosis of occupational disease and the detection status of suspected occupational disease and occupational contraindication in recent years in a petrochemical enterprise. METHODS: The data of new cases of occupational disease reported by a petrochemical enterprise from 2008 to 2019, the cases of suspected occupational disease and occupational contraindication from 2015 to 2019 were collected. The related data was descriptively analyzed. RESULTS: A total of 30 new cases of occupational disease were reported in this petrochemical enterprise from 2008 to 2019. Among them, there were 16 cases of occupational noise deafness, 10 cases of chronic occupational benzene poisoning, 2 cases of occupational leukemia caused by benzene, 1 case of occupational solvent gasoline poisoning and 1 case of occupational pneumoconiosis. Among the 30 cases of occupational diseases, 28 cases(93.3%) were related to benzene and noise exposure, and 19 cases(63.3%) came from the chemical and oil refining divisions. From 2015 to 2019 in this petrochemical enterprise, 24 cases of suspected occupational disease were reported, of which 17(70.8%) suspected cases were diagnosed as occupational disease, and 63 cases of occupational contraindication were reported, including 47(74.6%) cases of occupational contraindication caused by noise. CONCLUSION: Benzene and noise should be taken as the key factors of occupational hazard for prevention and control in the petrochemical enterprises, and control measures should be adopted for special operation links and job posts to control the hidden dangers of benzene and noise that exceeds the standard limits.

2.
China Occupational Medicine ; (6): 703-710, 2016.
Article in Chinese | WPRIM | ID: wpr-877012

ABSTRACT

OBJECTIVE: To establish an indicator system for risk assessment on occupational dust hazards and verify its application. METHODS: Using Delphi method,two rounds of investigation were made from 30 experts who work on frontline occupational health. The indicator system for risk assessment was established based on the investigation,statistics and boundary value,in fully consideration with the interaction of three basic elements of“dust inherent characteristics-laborers factors-influencing factors”. The indicator system was applied to evaluate the risk of 90 workplaces in the presence of dust occupational risk factors. RESULTS: The positive coefficient of experts' opinion was 90%,and the coefficient of experts' authority was 0. 808. The coefficient of experts' consensus was 0. 50( χ~2= 120. 56,P < 0. 01). The indicator system for risk assessment on occupational hazards of dust factors has been successfully established. This system included three class A indicators,nine class B indicators and twenty-eight class C indicators. The total coincidence rate of assessments on the risk level of occupational dust hazards of workplaces was 60%( Kappa = 0. 452,P < 0. 01). CONCLUSION: This indicator system was objective,scientific and feasible,and could reflect the actual levels of occupational dust hazards.

3.
Article in Chinese | WPRIM | ID: wpr-324208

ABSTRACT

<p><b>OBJECTIVE</b>To explore the effects of noise exposure level and cumulative noise exposure (CNE) on the relationship between rs2070424 and rs10432782 SNPs in SOD1 and the susceptibility to noise-induced hearing loss (NIHL).</p><p><b>METHODS</b>A case-control study was performed for investigating the effects of environmental risk factors on the susceptibility to NIHL in 201 sensitive workers and 202 resistant workers.A questionnaire was utilized to investigate the occupational health and to identify the occupational risk factors. The noise exposure levels were detected according to the Chinese standard Measurement of noise in the workplace (GBZ/T 189.8-2007). The peripheral blood samples (5 ml blood for each sample) were from sensitive workers and resistant workers. Genomic DNA was extracted on the basis of the standard procedures of Takara kit. SNPs were detected using standard procedures of TaqMan probe allele identification method.</p><p><b>RESULTS</b>In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the AA genotype of rs2070424 was lower than that in the subjects with the GG genotype, OR = 0.37 (95%CI: 0.17∼ 0.80). In group exposed to > 82 dB CNE (A), the AA genotype of rs2070424 is a protective factor of NIHL, as compared with the GG genotype, OR = 0.25 (95%CI: 0.09 ∼ 0.70). In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the GG genotype of rs10432782 was compared with the risk of NIHL in the subjects with the TT genotype, OR = 3.17 (95%CI: 1.16 ∼ 6.89). The GT genotype was compared with TT genotype, OR = 2.39 (95%CI: 1.16 ∼ 4.97). In group exposed to 75 ∼ 82 dB CNE (A), the risk of NIHL in the subjects with the GG genotype was compared with the risk of NIHL in the subjects with the TT genotype, OR = 2.35 (95%CI: 0.96 ∼ 5.72), P = 0.06. The GG genotype may bea risk factor of NIHJ.</p><p><b>CONCLUSION</b>The noise exposure level and CNE may influence the relationship between rs2070424, rs10432782 SNPs in SOD1 and noise-induced hearing loss.</p>


Subject(s)
Adult , Case-Control Studies , Female , Genetic Predisposition to Disease , Genotype , Hearing Loss, Noise-Induced , Genetics , Humans , Male , Noise, Occupational , Polymorphism, Single Nucleotide , Superoxide Dismutase , Genetics , Superoxide Dismutase-1 , Surveys and Questionnaires
4.
Article in Chinese | WPRIM | ID: wpr-282491

ABSTRACT

<p><b>OBJECTIVE</b>To observe the association between SNPs in SOD1 (rs1041740, rs2070424, rs10432782 and rs4998557) and noise-induced hearing loss in Chinese Han population.</p><p><b>METHODS</b>A case-control study was used to study the effects of environmental risk factors on the susceptibility to noise induced hearing loss (NIHL) in 201 sensitive workers and 202 resistant workers. A questionnaire was designed to carry out an investigation, and an occupational health survey was used to identify the occupational risk factors. Genomic DNA was extracted from peripheral blood cells using standard procedures of Takara kit, and 5 ml blood was from each subject. SNPs were detected using standard procedures of TaqMan probe allele identification method.</p><p><b>RESULTS</b>In SOD1 gene, the A allele of rs2070424 was a protective factor of NIHL, compared with the G allele (OR = 0.67, 95%CI: 0.50 approximately 0.88). The risk with NIHL in subjects with AA genotype was significantly lower than that in subjects with GG genotype (OR = 0.48, 95%CI: 0.26 approximately 0.79). After adjusting the confusion factors, OR was 0.44 and 95%CI was 0.25 approximately 0.78.</p><p><b>CONCLUSION</b>In Chinese Han population, the SNP of rs2070424 in SOD1 may be associated with the susceptibility to NIHL.</p>


Subject(s)
Adolescent , Adult , Alleles , Asian Continental Ancestry Group , Genetics , Case-Control Studies , Female , Genetic Predisposition to Disease , Genotype , Haplotypes , Hearing Loss, Noise-Induced , Epidemiology , Genetics , Humans , Male , Noise, Occupational , Polymorphism, Single Nucleotide , Risk Factors , Superoxide Dismutase , Genetics , Superoxide Dismutase-1 , Young Adult
5.
Article in Chinese | WPRIM | ID: wpr-349936

ABSTRACT

<p><b>OBJECTIVE</b>To study the adaptive response mechanisms in high background radiation area (HBRA) among Yangjiang local people through gene and protein expression of receptor for advanced glycation end products (RAGE) and S100A6 in peripheral blood and sputum in inhabitants of HBRA.</p><p><b>METHODS</b>A total of 53 male inhabitants were selected from HBRA in Yangjiang as the exposure group, while 53 male inhabitants were selected from Enping (control area, CA)as the control group. The content of RAGE and S100A6 gene and protein were detected by RT-PCR and Western blotting assay. Thermo luminescent dosemeter(TLD) assay was used to measure the outside dose and estimate the effective dose.</p><p><b>RESULTS</b>The effective dose in CA and HBRA was respectively 1.95 mSv and 6.24 mSv, which was 3 fold difference. Compared with CA, RAGE and S100A6 expression were significantly reduced in both gene and protein level in HBRA. The relative median mRNA expression of RAGE and S100A6 in peripheral blood were respectively 0.28, 1.06 and 0.16, 0.79 in CA and HBRA group, there was significance (with analysis Z values of -2.587 and -2.328 respectively, P < 0.05) with Wilcoxon rank test. For the protein of sputum, the relative median expression were respectively 2.98, 2.25 and 0.53, 0.47 with significant difference (with analysis Z values of -2.201 and -2.366 respectively, P < 0.05) by Wilcoxon rank test.</p><p><b>CONCLUSION</b>The low expression of RAGE and S100A6 in HBRA group might be correlated with the adaptive response and the low mortality of cancer in HBRA.</p>


Subject(s)
Adaptation, Physiological , Radiation Effects , Background Radiation , Cell Cycle Proteins , Metabolism , China , Humans , Male , Middle Aged , Receptor for Advanced Glycation End Products , Receptors, Immunologic , Metabolism , S100 Calcium Binding Protein A6 , S100 Proteins , Metabolism , Sickness Impact Profile
6.
Article in Chinese | WPRIM | ID: wpr-343054

ABSTRACT

<p><b>OBJECTIVE</b>To study the methylation of O-6-methylguanine-DNA methyltransferase (MGMT) and p16 gene in the sputum cells of radon-exposed population. To provide the experimental base for finding the molecular biomarker of the high risk population of the radon-induced lung cancer.</p><p><b>METHODS</b>91 radon-exposed workers were divided into 4 groups, high dosage group (> 120 WLM), middle dosage group (between 60 and 120 WLM), low dosage group (between 30 and 60 WLB) and lower dosage group (between 2 and 30 WLM) according to the accumulated exposure dosage of the radon daughters. The abnormal methylation of p16 and MGMT gene in the sputum cells of the population in the four groups was detected with the methylation specific PCR (MSP).</p><p><b>RESULTS</b>There was significantly upward trend for the p16 gene methylation rate (0.00%-20.00%), the MGMT gene methylation rate (0.00%-28.00%) and the total methylation rate (0.00%-40.00%) with the increase of the accumulated exposure dosage of the radon daughters (P < 0.01).</p><p><b>CONCLUSION</b>The methylation of p16 and MGMT gene is related to the accumulate exposure dosage of the radon daughters.</p>


Subject(s)
Carcinogens, Environmental , Cyclin-Dependent Kinase Inhibitor p16 , Genetics , Metabolism , DNA Methylation , Dose-Response Relationship, Radiation , Humans , Male , O(6)-Methylguanine-DNA Methyltransferase , Genetics , Metabolism , Occupational Exposure , Radon , Radon Daughters , Sputum , Metabolism
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