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Article in Chinese | WPRIM | ID: wpr-906161


Zexietang is derived from Jingui Yaolue (《金匮要略》), which is composed of Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma, and has the effect of inducing diuresis and invigorating the spleen to produce water. Compared with western medicine in the treatment of related diseases, Zexietang can not only improve the curative effect, but also reduce the occurrence of adverse reactions, so as to achieve long-term stable administration. The authors sorted out and analyzed the chemical composition, pharmacological effect and clinical application of Zexietang in recent years. It was found that the main active components of Zexietang were alismol A and B, 23-acetyl-alismol B and C, atractylenolides (atractylenolide Ⅰ, Ⅱ, Ⅲ) and polysaccharides. Pharmacological experiments showed that they had diuretic, hypolipidemic, anti-inflammatory and others. And it can be used in the treatment of hypertension, hyperlipidemia, vertigo, cerebral vascular insufficiency and other diseases combined with other Chinese materia medica, and the curative effect is obvious. By summarizing the research status of Zexietang in recent years, its active components and pharmacological mechanism can be further clarified, which provides the basis for the clinical application of Zexietang and guides the direction of its further research.

Article in Chinese | WPRIM | ID: wpr-350181


To optimize the purification process of gynostemma pentaphyllum saponins (GPS) based on "adjoint marker" online control technology with GPS as the testing index. UPLC-QTOF-MS technology was used for qualitative analysis. "Adjoint marker" online control results showed that the end point of load sample was that the UV absorbance of effluent liquid was equal to half of that of load sample solution, and the absorbance was basically stable when the end point was stable. In UPLC-QTOF-MS qualitative analysis, 16 saponins were identified from GPS, including 13 known gynostemma saponins and 3 new saponins. This optimized method was proved to be simple, scientific, reasonable, easy for online determination, real-time record, and can be better applied to the mass production and automation of production. The results of qualitative analysis indicated that the "adjoint marker" online control technology can well retain main efficacy components of medicinal materials, and provide analysis tools for the process control and quality traceability.

Article in Chinese | WPRIM | ID: wpr-350705


<p><b>OBJECTIVE</b>To establish an HPLC method for the determination of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p><p><b>METHOD</b>Pheny ether chromatographic column (4.6 mm x 250 mm, 5 microm) was adopted, with acetonitrile-0.1% phosphoric acid (containing 0.1% three ethylamine) (3:97) as the mobile phase. The UV detection wavelength was at 210 nm, with the flow rate of 1 mL x min(-1), and column temperature was at 35 degrees C.</p><p><b>RESULT</b>The linearity of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin ranged between 0.078 60-3.144 microg (r = 1.000 0), 0.103 4-2.068 microg (r = 0.999 7) and 0.430 5-3.157 microg (r = 0.999 8), respectively. Their average recoveries were 98.46% (RSD 1.1%), 103.0% (RSD 1.5%) and 97.15% (RSD 2.1%), respectively.</p><p><b>CONCLUSION</b>The method is simple, stable and reliable that it can be used to determine the content of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p>

Amygdalin , Chemistry , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Chemistry , Ephedrine , Chemistry , Linear Models , Pseudoephedrine , Chemistry , Reproducibility of Results , Time Factors
Article in Chinese | WPRIM | ID: wpr-256337


<p><b>OBJECTIVE</b>To establish the quality standard of yinhuang langxiao granule.</p><p><b>METHOD</b>The Panax notoginseng, Arnebia euchromq, Cornus officinalis, Lonicera japonica, Artemisiae annua were identified by TLC. The content of chrysophanol in granule was determined by HPLC.</p><p><b>RESULT</b>Spots of samples on TLC can be well separated and the method had good specificity. The average recovery of chrysophanol was 98.7% and RSD was 0.67%.</p><p><b>CONCLUSION</b>An accurate, simple and effective quality-controlling method has been developed, which can be used for quality control for yinhuang langxiao granule.</p>

Anthraquinones , Artemisia , Chemistry , Boraginaceae , Chemistry , Chromatography, High Pressure Liquid , Chromatography, Thin Layer , Cornus , Chemistry , Drug Combinations , Drugs, Chinese Herbal , Chemistry , Lonicera , Chemistry , Panax , Chemistry , Plants, Medicinal , Chemistry , Quality Control , Rheum , Chemistry
Article in Chinese | WPRIM | ID: wpr-263649


<p><b>OBJECTIVE</b>To evaluate different methods by treating water-decocted liquid of 6 Chinese medical herbs and 4 co-prescription respectively with alcohol, ultrafilter, macroporousresin and clarifier.</p><p><b>METHOD</b>The contents of target component in those extracts were determined with HPLC or titration, and quantitative and qualitative determination of the impurity components, such as polysaccharide and protein, was made.</p><p><b>RESULT</b>Each method showed its advantages and disavantages.</p><p><b>CONCLUSION</b>Different method can be chosen according to the clinical and preparation demands or the characteristic of components.</p>

Drug Combinations , Drugs, Chinese Herbal , Methods , Plants, Medicinal , Chemistry , Polysaccharides