ABSTRACT
Object To study the separation effect of three macoroporous resins for lycopene and ? carotene, in order to optimize the suitable one. Methods The performances of adsorption and desorption for lycopene and ? carotene with three macroporous resins D4020, X 5 and AB 8 were compared, and adsorption dynamics process of resins was studied. Results The adsorptive capacities of X 5 resin for lycopene and ? carotene are the most, they are 7 44 and 11 2 mg/g, respectively. Desorption ratio of X 5 resin is the highest. Conclusion X 5 resin is an ideal adsorbent for lycopene and ? carotene extraction.
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Objective: To experimentally research the supercritical carbon dioxide extraction of ? carotene in spirulina powder. Methods: Inspected the effect of such different condition as pressure (10～50MPa), temperature (20～50 ?C ) and flow rate of carbon dioxide (10～35kg/h) on the extract process. Results: The extraction yield was increased with increasing the pressure and temperature. Conclusion: The optimum operating condition of supercritical CO 2 extraction were as follows: pressure 25～35MPa and temperature 20～40 ?C and flow rate of CO 2 20～25kg/h.
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? carotene could decrease significantly the ear index and the quantity of Evan' s blue exudation that were skin photosensitive side actions in mice treated by photodynimic therapy ( PDT ) . The PGE 1 content in skin and the histamine content in skin and blood of mice were remarkably raised by raised by PDT. For example, the PGE 1 content in hematoporphyrin derivative group was 6.4 fold greater than that of control group. The PGE1 and histamine cotents were obviously decreased to nearly normal level by pretreatment with ? carotene. The results indicated that ? carotene can antagonise the skin photosensitive side action induced by PDT and the action was related to the decrease of PGE1 and histamine content in skin of mice. The cyclo-oxidase inhibitor indomethacin and the H1 receptor blocker benadryl could also decrease ear index and the quantity of Evan' s blue exudation
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Serum vitamin A, beta-carntene and lgG, IgA, IgM and T-lymphocyte Mastogenesis were measured in lung cancer patients, nonmalignant lung, disease and healthy controls matched lor age, sex and smoking. Mean serum vitamin A of lung cancer (except 5 adenocarcinoma) was significantly lower than that of healthy controls and non-malignant lung disease. Beta-caroiene levels were within the normal range, but mean serum beta-carotene concentration oi lung cancer patients was 24.7% lower, IgA of lung career and non-malignant lung disease patients was significantly higher, IgM and the rate of T-lymphocy te, blastogenesis of patients with lung cancer were lower than that of healthy controls, respectively. Serum IgG was not significant in 3 groups. An inverse relation, between serum vitamin A and IgM of hcalthy controls and arelation between serum vitamin A and IgG of lung cancer patients were observed. These data demonstrate an influence of vitamin A on immune function in lung cancer patients.
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Objective: To examine the effects of ? carotene and ? tocopherol on LDL oxidation by monocyte derived macrophages from SD rats (in DMEM medium). [WT5FZ]Methods: Macrophages were incubated with LDL in DMEM in which freshly dissoved VE (40,100,200 ?mol/L) and ?C (0.5,1.0,2.0 ?mol/L) had been added. After incubating for 24 h, the mediums were centrifuged to determine TBARS and lipofusin and dienes. [WT5FZ]Results: Supplementation of ? tocopherol significantly decreased TBARS, lipofusin and conjugated dienes production and electrophoretic mobility. Supplementation of ? carotene at 0.5 ?mol/L significantly decreased TBARS, lipofusin and conjugated dienes production and electrophoretic mobility, but other levels showed no effect. Increasing ? carotene concentration to 2.0 ?mol/L in the system increased the lipofusin production compared with control group. ? tocopherol at 200 ?mol/L and ? carotene at 0.5 ?mol/L were the most effective in all dose groups. [WT5FZ]Conclusion: Cell mediated oxidation of LDL can be regulated by antioxidants such as ? tocopherol and ? carotene.