Antihypertensive effect of 3,6-di (dimethylamino) dibenzopyriodonium fromate (IHC-64) / 中国药理学通报

The blood pressure of conscious and anaesthetized animals feel significantly after iv IHC-64. IHC-64 acts rapidly but the time of acts was short. No acute tolerance was observed. After iv IHC-64 0. 5 and 1. 5 mg?kg-1 in anaesthetized dogs the blood pressure feel immediately, lasted for 12?5 min and 30 min . After iv IHC-64 0. 75,1. 5 and 3. 0 mg?kg-1in anaesthetized rabbits the blood pressure fell within 0. 5~ 1.0 min and the time of acts was re-spectively 10?5 min,12?7 min and 19?11 min . Antihypertensive effect of IHC-64 was more powerful than that of Clonidine and was similar to Sodium Notroprusside. The dosage of antihypertensive effect didn't affect the heart rate of conscious rabbits and anaesthetized dogs.