ABSTRACT
Objective To investigate the changes of the platelet function in APP/PS-1/tau(3xTg) mice, a murine model for Alzheimer''s disease,and explore its mechanisms.Methods We assessed the change of function of platelet in 3xTg-AD mice by flow cytometry.Adhesion assay and Western blotting were used to compare with the data of wild type mice.Results Platelets from aged 3xTg-AD mice were normal in number and glycoprotein expression (P>0.05), but adhere more avidly on matrices such as fibrinogen, compared with the platelets from age-matching wild type mice (P0.05).Conclusions These results demonstrate that Alzheimer''s mutations result in a significant hyper-activated adhesion state of circulating platelets, evident with the progression of the disease.