ABSTRACT
RESUMEN La anetodermia primaria es una dermatosis de baja frecuencia, crónica, la cual se caracteriza por pérdida de fibras elásticas. En algunas ocasiones se ha observado en pacientes con enfermedades autoinmunes, entre ellas el lupus eritematoso sistémico (LES). Presentamos un caso de LES asociado a anetodermia, en una paciente de sexo femenino, de 19 años de edad.
ABSTRACT Primary anetoderma is an infrequent skin disease that has sometimes been observed in patients with autoimmune diseases such as systemic lupus erythematosus. We present a case of systemic lupus erythematosus associated with anetoderma, in a 19-year-oldfemale patient.
ABSTRACT
La anetodermia es un trastorno elastolítico infrecuente, caracterizado clínicamente por áreas de piel laxa y pérdida o disminución de las fibras elásticas en la histología. Este hallazgo sin enfermedad cutánea previa es conocido como anetodermia primaria y se suele asociar a enfermedades autoinmunes; dentro de éstas el lupus eritematoso sistémico (LES), con anticuerpos antifosfolipídicos, y el síndrome antifosfolipídico (SAF) son las más frecuentes. Presentamos una paciente con anetodermia primaria, LES y anticuerpos antifosfolipídicos positivos sin clínica de SAF (AU)
Anetoderma is an infrequent elastolytic disorder, clinically characterized by areas with lack of the skin and decreased elastic fibers at histology. This finding without previous skin disease is known as primary anetoderma and is often associated with autoimmune diseases such as systemic lupus erythematosus (SLE), with antiphospholipid antibodies, and antiphospholipid syndrome (APS). A female patient with primary anetoderma, SLE and positive antiphospholipid antibodies without clinical APS is reported (AU)
Subject(s)
Humans , Female , Adult , Anetoderma/diagnosis , Lupus Erythematosus, Systemic/complications , Antiphospholipid SyndromeABSTRACT
Idiopathic Atrophoderma of Pasini and Pierini (IAPP) is a rare, exclusively cutaneous disease. It is more frequent in females, with incidence peak in the second and third decades of life. The etiopathogenesis remains unknown. IAPP most commonly affects the back, abdomen and proximal regions of the limbs. Lesions may be rounded, oval or circular; single or multiple. The evolution is variable and the course is initially progressive. Collagen changes such as atrophy, thinning, condensation and sclerosis may be observed in the papillary dermis. This paper describes a case of Idiopathic Atrophoderma of Pasini and Pierini with histopathologic findings.
Subject(s)
Humans , Female , Adolescent , Skin/pathology , Skin Diseases/pathology , Atrophy , Diagnosis, DifferentialABSTRACT
Anetoderma is a rare cutaneous disorder characterized by a loss of normal elastic tissue that presents clinically as atrophic patches located mainly on the upper trunk. Recent studies suggest immunological mechanisms may play a role in this process. Furthermore, a secondary form of macular atrophy occurs in the course of infectious diseases (e.g. syphilis and tuberculosis) and autoimmune disease (e.g. systemic lupus erythematosus [SLE]). Here, we report the case of a 20-year-old woman previously diagnosed with SLE, who presented with numerous well-circumscribed atrophic macules on the face and upper trunk. Histopathological examination showed decreased elastic tissues in the reticular dermis and mononuclear cells adhering to elastic fibers, consistent with anetoderma. Thus, the eruptive anetoderma localized widely on the face and upper trunk may have been caused by an autoimmune response of SLE.
Subject(s)
Female , Humans , Young Adult , Anetoderma , Atrophy , Autoimmune Diseases , Autoimmunity , Communicable Diseases , Dermis , Elastic Tissue , Lupus Erythematosus, Systemic , SyphilisABSTRACT
La Anetoderma es una enfermedad elastolítica rara que se caracteriza por la pérdida focal de tejido elástico en la dermis. La patogénesis de esta enfermedad es desconocida y ha sido descrita en asociación con enfermedades autoinmunes, como lupus eritematoso y síndrome antifosfolípidos, y con enfermedades infecciosas, principalmente VIH, sífilis y borreliosis. Su diagnóstico diferencial es amplio e incluye otras enfermedades elastolíticas, liquen escleroatrófico extragenital y morfea, entre otros. Se reporta el caso de una paciente que consultó por un cuadro de larga data de múltiples parches blanquecinos atróficos, cuya biopsia cutánea fue compatible con Anetoderma. Se realiza una revisión de la literatura dada la necesidad de un adecuado estudio y seguimiento de estos pacientes en busca de una pesquisa temprana de enfermedades autoinmunes asociadas.
Anetoderma is a rare elastolytic disease characterized by focal loss of elastic tissue in the dermis. Pathogenesis is unknown and has been described in association with autoimmune diseases such as lupus erythematosus and antiphospholipid syndrome, and infectious diseases, especially HIV, syphilis and Lyme disease. Differential diagnosis is broad and includes other elastolytic disease, extragenital lichen sclerosus and morphea. We report the case of a patient with long-standing history of multiple atrophic white patches on the trunk and extremities, with diagnostic skin biopsy of Anetoderma. We conducted a literature review given the importance of good study and monitoring of these patients for an early investigation of associated autoimmune diseases.
Subject(s)
Humans , Adult , Female , Anetoderma/diagnosis , Anetoderma/pathology , Diagnosis, DifferentialABSTRACT
Comunicamos un caso de anetodermia secundaria a la infección por moluscos contagiosos, en una niña de 12 años de edad, secuela infrecuente pero de difícil tratamiento.
A 12 years-old girl with many anetoderma scars following molluscum contagiosum infection was reported, this unusual dermatosis residual to molluscum contagiosum are difficult to treat.
ABSTRACT
Anetoderma is characterized by a loss of normal elastic tissue, and is clinically presented as atrophic patches located mainly on the upper trunk. It may be primary or secondary, occurring in the course of various dermatoses. The most common diseases among them are acne and varicella, but there are several reports about other skin diseases causing anetoderma. A 16-year-old girl visited our clinic for the evaluation of asymptomatic atrophic macules on the head, upper trunk and lower extremities. She had a 10-month history of yellowish brown papules located on the same area fifteen years ago. Histopathologic findings at that time showed histiocytic infiltration with foam cells and Touton giant cells in the dermis, which were consistent with juvenile xanthogranuloma (JXG). Skin biopsy was carried out at an atrophic macule; histologic findings revealed a decrease in dermal elastic fibers. All these findings were compatible with anetoderma. To our knowledge, this case is the first report of anetoderma developed in JXG in Korea.
Subject(s)
Adolescent , Female , Humans , Acne Vulgaris , Anetoderma , Biopsy , Chickenpox , Dermis , Elastic Tissue , Foam Cells , Giant Cells , Head , Korea , Lower Extremity , Skin , Skin Diseases , Xanthogranuloma, JuvenileABSTRACT
The vast majority of mastocytosis appear in childhood, urticaria pigmentosa (UP) and mastocytomas being the most common types. Terms such as "xanthelasmoid mastocytosis", "pseudoxanthomatous mastocytosis" or "nodular mastocytosis" have been introduced in the literature to describe the presence of yellowish papular or nodular lesions. We describe two children with cutaneous mastocytosis showing yellowish lesions in combination with other skin lesions. A 10-year-old girl presented with asymptomatic lesions in her vulva at birth, and developed brownish macules on her trunk years after. An eight- year-old boy presented with multiple yellowish papular lesions on his trunk, neck and limbs coexisting with a few clinically anetodermic lesions. No systemic involvement was found and the skin biopsy confirmed a cutaneous mastocytosis in both cases. The two patients are currently asymptomatic and are being periodically followed up. Mastocytoses may show a variety of clinical lesions, sometimes leading to misdiagnosis. Although there are previous reports, involvement of the mucosae and secondary anetoderma are not common findings in cutaneous mastocytoses. We consider that cutaneous manifestations of mastocytoses compose a clinical spectrum, thus explaining the coexistence of different clinical lesions and the development of uncommon presentations.
ABSTRACT
La anetodermia es un trastorno elastolítico raro, que se caracteriza por áreas circunscriptas de piel fláccida. Su patogenia es desconocida, pero existen mecanismos inmunológicos que cumplen un rol importante durante la elastólisis en la dermis. Realizamos una revisión de la bibliografía y proponemos una nueva clasificación. Ësta incorpora a la anetodermia primaria asociada a anticuerpos antifosfolípidos, ya que su presencia es determinante en el pronóstico de los pacientes.
Anetoderma is a rare elastolytic disorder characterized by circumscribedareas of slacked skin. Its pathogenesis is unknown, but immunologicalmechanisms play an important role in dermal elastolysis.We make a review of the literature and propose a new classifi cation. It incorporatesprimary anetodermia associated to antiphospholipid antibodiestaking into account that their presence is crucial for the prognosis ofthe patient (Dermatol Argent 2009;15(5):324-333).
Subject(s)
Humans , Elastic Tissue , Skin , Diagnosis, DifferentialABSTRACT
Atrophic dermatofibrosarcoma protuberans (DFSP) is an uncommon clinical variant, which clinically mimics other atrophic dermatological conditions. Given the typical 'protuberant' morphology of DFSP, such atrophic lesions may be difficult to diagnose clinically. We report a 44-year-old man who presented with an 8-month history of an asymptomatic, depressed, anetoderma-like plaque on the right subclavicular area. He also presented with a 1-year history of a 1.5x1.5 cm, asymptomatic, firm, erythematous nodule above an atrophic lesion. Biopsy specimens were taken from each lesion. These specimens, along with histochemical staining for CD34, established the diagnosis of dermatofibrosarcoma protuberans.
Subject(s)
Adult , Humans , Anetoderma , Biopsy , DermatofibrosarcomaABSTRACT
Pilomatricoma, also known as the calcifying epithelioma of Malherbe, is a benign adnexal neoplasm that arises from primitive cells of the hair matrix. It usually appears as a firm, slowly growing dermal or subcutaneous nodule, almost solitary but occasionally multiple. Anetoderma is characterized clinically by discrete, atrophic skin lesions and pathologically by the focal loss of elastic fibers in the dermis. Anetodermic cutaneous changes in the skin overlying a pilomatricoma have been rarely described in the literature. Herein, we report 17-year-old girl who presented with two skin lesions, one of which was a painful nodule with bag-like, wrinkled surface on the left posterior shoulder and the other was asymptomatic deep seated nodule with skin colored surface on the left upper back. The histopathologic examination showed typical findings of pilomatricoma, and anetoderma was associated with tender nodule on the shoulder.
Subject(s)
Adolescent , Female , Humans , Anetoderma , Dermis , Elastic Tissue , Hair , Pilomatrixoma , Shoulder , SkinABSTRACT
Anetoderma is characterized by atrophic patches located mainly on the upper trunk. Secondary anetoderma occurs in the courses of various diseases, such as syphilis, lupus erythematosus, and leprosy. Among them secondary anetoderma due to pilomatricoma is rare and has a characteristic skin manifestation such as scrotal skin or round striae. Herein we report four cases of pilomatricomas with secondary anetodermic cutaneous changes. The overlying skin appeared variously as a pinkish, wrinkled, bag-like bulged, or scar-like atrophic surface. However the histopathologic examination showed commonly a prominent decrease of elastic fibers in the dermis overlying the pilomatricoma mass.
Subject(s)
Anetoderma , Dermis , Elastic Tissue , Leprosy , Pilomatrixoma , Skin , Skin Manifestations , SyphilisABSTRACT
Actinic granuloma (O'Brien) is an annular inflammatory reaction that develops in skin after long-term sun-exposure. Anetoderma is characterized by discrete skin lesions that appear to be loose and wrinkled. The primary type arises in clinically normal skin, and the secondary type appears in lesions of other disorders. We describe a case of anetoderma that developed on the neck, both arms and calves, and showed histopathological findings of actinic granuloma.
Subject(s)
Actins , Anetoderma , Arm , Granuloma , Neck , SkinABSTRACT
We report a case of actinic granuloma in a 39 year-old woman who was presented with multiple anetoderma on non-sun exposed skin such as the neck, upper arms, elbows and calfs. The anetodermic presentation of actinic granuloma has never been reported and the common pathogenesis involving reduction of elastic fibers link the two disorders. Anetoderma secondary due to actinic granuloma should to be included in the list of secondary anetoderma and may suggest one of the possible pathogenesis of anetoderma.
Subject(s)
Adult , Female , Humans , Actins , Anetoderma , Arm , Elastic Tissue , Elbow , Granuloma , Neck , SkinABSTRACT
Anetoderma is a rare cutaneous disorder characterized by circumscribed loss of skin elasticity. This has been historically divided into inflammatory(Jadassohn-Pellizzari) and non-inflammatory(Schw eninger-Buzzi) type. We herein, report a case of Schweninger-Buzzi type anetoderma occurring on a 6 year-old girl. The lesions did not have an inflammatory onset. Histologically, the focal loss of elastic fibers was seen on the lesion.
Subject(s)
Child , Female , Humans , Anetoderma , Elastic Tissue , Elasticity , SkinABSTRACT
We report a case of secondary anetoderma due to pilomatricoma. A 15-year-old girl presented with a soft, 1.5 × 1.5cm in size, atrophic, pinkish and bulged-out lesion overlying the palpable subcutaneous mass on the left upper arm for several months. Histologic examination revealed the reduced number of dermal elastic fibers overlying a typical pilomatricoma.
Subject(s)
Adolescent , Female , Humans , Anetoderma , Arm , Elastic Tissue , PilomatrixomaABSTRACT
We report a case of secondary anetoderma due to pilomatricoma. A 15-year-old girl presented with a soft, 1.5 × 1.5cm in size, atrophic, pinkish and bulged-out lesion overlying the palpable subcutaneous mass on the left upper arm for several months. Histologic examination revealed the reduced number of dermal elastic fibers overlying a typical pilomatricoma.
Subject(s)
Adolescent , Female , Humans , Anetoderma , Arm , Elastic Tissue , PilomatrixomaABSTRACT
Anetoderma or Macular atrophy is a rare cutaneous disorder showing local atrophy and macular discoloration related to a local dermal defect of elastic tissiie without any other apparent change in the skin, which may show familial occurrence, called familial anetoderma. A 13-year-old female complained 3-year history of multiple asyrnptomatic atrophic macules on the trunk and both lower extremities, especially on both this. Elastic stain of skin lesion showed decrease of lastic tissue in the dermis. No other syst mic abnormalities were found on phisical examination. Her sister had same skin lesion on lower extremities and both buttocks, and had no ther systemic abnormalities. Despite infrequent occurence, the development of anetoderma among familial members possibly represents a congcnital defect of elastin. Because variou ocular, bony, cardiac, and gastrointestinal abnormalilies have been reported in familial anetoilerma, long-term follow up would be necessary.