ABSTRACT
Objective: To investigate the chemical constituents from the roots of Angelica dahurica. Methods: The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin and Sephadex LH-20 column as well as semi-preparative reversed phase HPLC. The chemical structures were identified by spectral data. Results: Ten compounds were isolated and identified as xanthoarnol-3′-O-β-D-glucopyranoside (1), angedahuricoside A (2), angedahuricoside B (3), isofraxidin-7-O-β-D-glucopyranoside (4), fraxidin-8-O-β-D-glucopyranoside (5), (-)-marmesinin (6), (2′S,3′R)-3′-hydroxymarmesinin (7), hyuganoside V (8), daucosterol (9), and sucrose (10). Conclusion: Compounds 1–3 are new ones and compounds 4–6 and 8 are obtained from title plant for the first time.
ABSTRACT
Objective: To study the chemical constituents of lipophilic parts from the roots of Angelica dahurica. Methods: The compounds were separated and purified by repeated column chromatography on silica gel and HPLC, as well as the chemical structures of isolated compounds were determined by spectral data analyses. Results: Forty compounds were obtained and identified as isoimperatorin (1), psoralen (2), bergapten (3), β-sitosterol (4), imperatorin (5), phellopterin (6), xanthotoxin (7), isopimpinellin (8), dehydrogeijerin (9), isooxypeucedanin (10), oxypeucedanin (11), dibutylphthalate (12), umbelliferone (13), xanthotoxol (14), 5-hydroxy-8-methoxypsoralen (15), p-hydroxyphenethyl-trans-ferulate (16), pabularinone (17), isobyakangelicol (18), heraclenin (19), columbianetin (20), isogosferol (21), pabulenol (22), byakangelicin ethoxide (23), neobyakangelicol (24), oxypeucedanin methanolate (25), isoscopletin (26), 1′, 2′-dehydromarmesin (27), angelol A (28), angelol E (29), tert-O-methylheraclenol (30), (-)-marmesin (31), dahurianol {8-[(2′R)-2′, 3′-dihydroxy-3′-methylbutoxy] bergaptol; 32}, oxypeucedanin hydrate (33), heraclenol (34), byakangelicin (35), angelol L (36), angelol G (37), trans-coniferylaldehyde (38), vanillic acid (39), and trans-ferulic acid (40), respectively. Conclusion: Compound 32 is a new natural product named dahurianol.