ABSTRACT
Sparganium stoloniferum is widely used in traditional Chinese medicines. It has been reported to exhibit therapeutic effects on thrombus, solid tumor, endometriosis and so on. It is usually used to treat endometriosis and chronic atrophic gastritis, while its underlying mechanisms are poorly delineated. According to vast information from literatures in the last decade, the research on origin of medica, chemical compositions and pharmacological actions were summarized, in hopes of offering more clues for further research as well as clinical application of S. stoloniferum.
ABSTRACT
Objective To investigate the effects of different anti thrombotic strategies on the risk of bleeding, cardiac events and quality of life in elderly patients with acute non ST segment elevation myocardial infarction.MethodsElderly patients with acute non ST elevation myocardial infarction 200 cases of complication in patients with atrial fibrillation, are in our hospital from May 2013 to December 2015 were cardiovascular department, after discharge according to different antithrombotic strategy, according to the 5 groups, including 40 cases of A group, 75mg/d+ 100mg/d treatment with clopidogrel and aspirin;B group 40 cases.Using warfarin therapy;40 cases in group C, 75mg/d or 100mg/d+ with clopidogrel aspirin warfarin therapy;40 cases in group D, using 75mg/d+ 100mg/d+clopidogrel aspirin warfarin therapy, group E received 75mg/d+ clopidogrel aspirin 100mg/d plus warfarin therapy, based on the use of psychological intervention.The risk of bleeding, cardiac events and quality of life scores were compared.ResultsStatistical analysis showed that the incidence of major cardiac events in E group (2.5%) and the quality of life were optimal (the data are statistically significant compared to P<0.05, A, B);C, D, E groups, the risk of major bleeding rate compared with no significant difference.ConclusionThe application of drugs and psychological intervention in the treatment of elderly patients with acute non ST segment elevation myocardial infarction patients can be more effective.
ABSTRACT
Tissue factor (TF), also called tissue thromboplastin, is the principal initiator of physiological blood coagulation and hemostasis and pathological thrombosis, and plays an important role in the formation of various diseases in atherosclerosis, systemic inflammation, angor pectoris, disseminated intravascular coagulation, and tumor angiogenesis and metastasis. Looking for the targets to TF anticoagulant, antithrombotic drug has important theoretical and realistic significance. This summary outlines the research progress of the active components in Chinese materia medica with modulating effects on expression of tissue factor in thrombosis in recent years.
ABSTRACT
OBJECTIVE: To study the antithrombotic activity of fucoidan with different molecular weight from Laminaria japonica, and to explore its mechanism by observing antiplatelet activities and fibrinolysis. METHODS: FeCl3-induced arterial thrombosis in rats were used to examine the antithrombotic activity of four fucoidan fractions with different molecular weight; the TXB2, 6-keto-PGF1α, PLG, t-PA and PAI-1 in plasma were determined by ELISA to evaluate the inhibitory effects of the drugs on platelet aggregation and fibrinolytic system. RESULTS: Four fucoidan fractions with different molecular weight could significantly decreased the weight of the thrombus, and Middle molecular weight (MMW) fucoidan fractions exhibited better antithrombotic activity than low molecular weight fucoidan (LMW). Administration of LMW fucoidan significantly decreased the TXB2 content and promoted 6-keto-PGF1α content. Administration of MMW fucoidan only decreased the TXB2 content and didn't change 6-keto-PGF1α content. In four fucoidan fractions group, the activity of t-PA were increased, the activity of PAI-1 were decreased, the ratio of t-PA/PAI-1 was increased, and the activity of PLG had no change. CONCLUSION: Four fucoidan fractions with different molecular weight have strong anti-thrombosis effect, the action mechanism may have correlation with the increase in the activities of anti-platelet aggregation and fibrinolysis system. Copyright 2012 by the Chinese Pharmaceutical Association.
ABSTRACT
This study was performed to investigate anti-thrombogenic, anti-inflammatory effects of n-BuOH (B) and CH2Cl2 (MC) fractions extracted from Sancho (Zanthoxylum. schinifolium) leaves in rats fed high fat diets. The experimental animal groups were consisted of eight including one 5% fat (N) and one 20% fat (H) without the test materials in diets and six H groups of feeding three levels (50, 100 and 150 mg/day) of the B and the MC fractions from Z. schinifolium, respectively. Plasma activated partial thromboplastin times and thrombin times of H group were decreased compared to the N group, but they were increased by feeding the MC fraction of 50 mg and over. Polymorphonuclear leukocyte 5'-lipoxygenase activities and leukocyte leukotriene B4 contents of the H group were significantly increased compared to the N group, but they were decreased in the 100 mg and 150 mg of B fraction or the 150 mg of MC fraction fed groups. Liver cytochrome P450, O2-, H2O2 and GSSG contents were increased by the high fat diet but decreased by feeding the B fraction or the MC fraction, while GSH content and glutathione S-transferase activity lowered by high fat diet were increased by feeding the two solvent fractions. The effects of the solvent fractions were evident at the level of 100 mg/day and over. The present results confirmed that two solvent fractions from the leaves of Z. schinifolium have enhancing effects on antithrombosis and anti-inflammation partly by antioxidant action and partly by direct modulation of the respective processeds. In conclusion, the n-BuOH and CH2Cl2 fractions from leaves of Z. schinifolium can be utilized as the proper ingredients of functional foods for preventing chronic degenerative disease.
Subject(s)
Animals , Rats , Cytochrome P-450 Enzyme System , Diet , Diet, High-Fat , Functional Food , Glutathione Disulfide , Glutathione Transferase , Leukocytes , Leukotriene B4 , Liver , Neutrophils , Plasma , Thrombin Time , Thromboplastin , ZanthoxylumABSTRACT
The experiments show that extract from Hippocampus trimaculatus Leach (EHT) can inhibit experimental common carotid artery and cerebral thrombosis in rats, and its effective ingredients are unsaturated fatty acids.