1.
Journal of Kunming Medical University
;
(12): 120-123, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-694545
ABSTRACT
Endothelial dysfunction is a major risk factor for vascular complication. Nitric oxide (NO),the most important product of endothelial cells,lays a key role in regulating vasomotor as an endogenous vasodilatation factor. NO is produced by endothelial NO synthase (eNOS) on its substrate L-arginine. Arginase,which metabolizes L-arginine to urea and ornithine,competes directly with eNOS for L-arginine leading to the decrease of NO production. This paper reviews the basic role of arginase, the development of arginase inhibitors and its effects on diabetic vascular complications.