ABSTRACT
Objective To study the effects of Ziyin Bushen Pill on Aristolochia acid A in Aristolochia fangchi,and preliminary study on reducing poisonous effects of Ziyin Bushen Pill to Aristolochia fangchi.Methods Absorption of Aristolochhia acid A in the mingled decoction of Aristolochia fangchi and Ziyin Bushen Pill by HPLC,and the change of Aristolochia acid A was observed.Results Aristolochia acid A content of Aristolochia fangchi was markedly decreased after Ziyin Bushen Pill was added.Conclusion Ziyin Bushen Pill can markedly decreased Aristolochhia acid A content of Aristolochia fangchi.
ABSTRACT
OBJECTIVE: To study the attenuation action of Liuwei dihuang pill on Aristolochia Fangchi-induced toxicity through determination of the content of Aristolochia acid A in Aristolochia Fangchi. METHODS: After mixed decoction of Aristolochia Fangchi with Liuwei dihuang pill,the content of Aristolochhia acid A was determined by HPLC and the content change was observed. RESULTS: Aristolochia acid A content in Aristolochia Fangchi was markedly decreased after intervention by Liuwei dihuang pill. CONCLUSION: The attenuation action of Liuwei dihuang pill is related to the downregulation of Aristolochhia aicd A content in Aristolochia Fangchi.