Hip Ankylosis after Untreated Septic Arthritis by Escherichia coli: A Case Report / Anquilose do quadril após artrite séptica por Escherichia coli não tratada: Relato de caso

Abstract Septic arthritis is usually reported in elderly patients with other underlying medical conditions. Septic arthritis by Escherichia coli is a rare infection. We are describing the case of a 70-years old patient who presented with a suppurative fistula, limited movements of the right lower limb, and a trauma that occurred at the age of 12. Throughout this time, the fistula had been present, secreting pus. A detailed clinical investigation revealed a pyogenic infection present in the femoral epiphysis followed by an elevated sedimentation rate. After the surgical intervention, E. coli was isolated from the clinical samples, and the decision to place gentamicin beads within the surgical wound was taken. The patient was treated with antibiotics. Four months after the intervention, the suppurative fistula was completely healed. Later on, the patient was no longer interested anymore in continuing with the treatment plan. As he refused to remove the gentamicin chain beads and the hip endoprosthesis, he was subsequently referred to the primary care clinic for conservative management and follow-up. He walked with a limp wearing orthopedic shoes and not using crutches or any other type of walking-aid. Four years after the surgical intervention, the gentamicin chain beads are still within the bone. Septic arthritis caused by E. coli can remain active for decades, secreting pus and self-isolating. Prompt diagnosis, adequate surgical intervention, and antimicrobial therapy are essential for the treatment.

Resumo A artrite séptica é geralmente relatada em pacientes idosos com outras condições médicas subjacentes. Artrite séptica por Escherichia coli é uma infecção rara. Descrevemos o caso de um paciente de 70 anos que apresentou uma fístula supurativa, movimentos limitados do membro inferior direito, e um trauma ocorrido aos 12 anos de idade. Durante todo esse tempo, a fístula esteve presente, secretando pus. Uma investigação clínica detalhada revelou uma infecção piogênica presente na epífise femoral seguida de uma taxa elevada de sedimentação. Após a intervenção cirúrgica, E. coli foi isolada das amostras clínicas, e tomou-se a decisão de colocar pérolas de gentamicina dentro da ferida cirúrgica. O paciente foi tratado com antibióticos. Quatro meses após a intervenção, a fístula supurativa foi completamente curada. Mais tarde, o paciente não estava mais interessado em continuar com o plano de tratamento. Como ele se recusou a remover as pérolas da cadeia de gentamicina e a endoprótese de quadrile, ele foi posteriormente encaminhado para a clínica de atenção primária para manejo conservador e acompanhamento. Ele andava mancando usando sapatos ortopédicos, mas sem muletas ou qualquer outro tipo de dipositivo de auxílio para caminhar. Quatro anos após a intervenção cirúrgica, as pérolas da cadeia de gentamicina ainda estão inseridas no osso. A artrite séptica causada por E. coli pode ficar ativa por décadas, secretando pus e se isolando. Diagnóstico rápido, intervenção cirúrgica adequada, e terapia antimicrobiana são essenciais para o tratamento.

Fungal Osteomyelitis of the Hip with Septic Arthritis: Case Report / Osteomielite fúngica do quadril associado a artrite séptica: Relato de caso

Abstract Fungal osteomyelitis, especially associated with septic arthritis, is uncommon in Brazil; therefore, sometimes it is difficult to diagnose and treat it. We report the case of a young patient, with no immunosuppressive risk factor, with osteomyelitis leading to septic arthritis of the hip. The diagnosis was performed after surgical drainage and visualization of Cryptococcus neoformans at pathological anatomy. Antifungal treatment resulted in complete remission of the symptoms. Since there is no consensus on the treatment of fungal osteomyelitis, this case report aims to inform orthopedists about the importance of hip arthritis differential diagnosis and the good evolution of clinical treatment after drainage and pathogen isolation.

Resumo Osteomielites fúngicas, principalmente associadas à artrite séptica, são incomuns no Brasil, e por isso às vezes de difícil diagnóstico e tratamento. Relatamos um caso de uma paciente jovem, sem fator de risco imunossupressor, com o desenvolvimento de uma osteomielite e evolução para artrite séptica do quadril. O diagnóstico foi realizado após a sua drenagem cirúrgica e visualização do Cryptococcus Neoformans à anatomia patológica. Foi instaurado o tratamento antifúngico, com remissão total dos sintomas. Como não há consenso em relação ao tratamento de osteomielites fúngicas, descrevemos este relato de caso para atentar ortopedistas sobre a importância do diagnóstico diferencial nas artrites de quadril e a boa evolução do tratamento clínico após a drenagem e isolamento do patógeno.

Artritis séptica de rodilla por Serratia marcescens en paciente con hemofilia A

Presentamos el caso de un paciente varón de 24 años con hemofilia A de 14 años de evolución. El paciente presentó hemartrosis recurrente en rodilla derecha, luego desarrolló artritis séptica en dicha articulación producida por Serratia marcescens con respuesta satisfactoria al lavado intra-articular con solución salina y 28 días de tratamiento con carbapenémicos. En pacientes con artritis séptica, hemartrosis previa y múltiples ingresos hospitalarios debe sospecharse la presencia de este germen. El tratamiento es quirúrgico y con antibióticos de amplio espectro.

We present the case of a 24-year-old male patient with hemophilia A of 14 years of evolution. The patient presented recurrent hemarthrosis in the right knee, who developed septic arthritis in knee due to Serratia marcescens with a satisfactory response to intra-articular lavage with saline solution and 28 days of treatment whith carbapenems. In patients with septic arthritis, previous hemarthrosis and multiple hospital admissions, the presence of this germ should be suspected. The treatment is surgical and with broad spectrum antibiotics.

A case report of suppurative acromioclavicular arthritis and literature review / 中华骨科杂志

One case of suppurative acromioclavicular arthritis caused by Staphylococcus aureuswas reported. The patient was admitted to hospital due to swelling and pain in the right shoulder, limited mobility without no obvious cause.Through medical history, physical examination, imaging examination, and local tissue bacterial culture, it was confirmed that the infection was caused by Staphylococcus aureus. After surgery and anti infection treatment, satisfactory treatment results were achieved. Through literature review, 95 cases of suppurative acromioclavicular arthritis were retrieved and analyzed from 57 articles.Among them, 26 cases (27%) were infected with Staphylococcus aureus, including 3 cases of clearly identified methicillin-resistant Staphylococcus aureus, 2 cases of methicillin-sensitive Staphylococcus aureus, and 1 case of methicillin-resistant Staphylococcus epidermidis; 13 cases (14%) of Streptococcus; There were 6 cases (6%) of special pathogens, including 2 cases of Haemophilus parainfluenzae, 1 case of Candida, 1 case of Bacillus pallidum, 1 case of Mycobacterium avium, and 1 case of Pasteurella multocida; 50 cases (53%) of specific infections with pathogens were not clearly reported. Suppurative acromioclavicular arthritis has the characteristics of difficult early diagnosis, rapid disease progression, and strong destructiveness. MRI and ultrasound have high specificity and sensitivity in the diagnosis of this disease, and ultrasound can assist in obtaining joint fluid for examination. Early identification of the pathogen is the key to the treatment of this disease. Before identifying the pathogen, antibiotics should not be used arbitrarily. After diagnosis, timely anti infection treatment should be carried out, and if necessary, surgical debridement should be performed. The vast majority of patients can achieve satisfactory and accurate treatment results after active and standardized treatment.

Perfil epidemiológico de los pacientes entre 0 y 15 años con infección osteoarticular en el Hospital Infantil San Vicente Fundación / Epidemiological profile of patients between 0 and 15 years with osteoarticular infection at the San Vicente Fundación Children's Hospital

RESUMEN Introducción: el principal patógeno en las infecciones osteoarticulares es el Staphylococcus aureus, los esquemas de tratamiento recomendados se basan en la literatura estadounidense o europea, no hay datos de estudios locales. El propósito de este estudio es conocer el perfil epidemiológico en las infecciones osteoarticulares del Hospital Infantil San Vicente Fundación (Medellín, Colombia) y las características de los pacientes afectados. Materiales y métodos: revisión retrospectiva de historias de pacientes entre los 0 y 15 años con diagnóstico de infección osteoarticular en el Hospital Infantil San Vicente Fundación, se detallaron las variables demográficas de la patología y los antecedentes relevantes para caracterizar el perfil epidemiológico de las infecciones osteoarticulares. Resultados: identificamos 72 pacientes con infección osteoarticular. La infección más común fue la artritis séptica (40 %), seguida por la osteomielitis aguda (37 %). La cadera (18 %) y la tibia (31 %) fueron la articulación y el hueso afectados con mayor frecuencia. La mayoría de las infecciones fueron secundarias a S. aureus (65 %), de estas fueron por Stafilococo aureus meticilino sensible (SAMS) el 38,9 % y por Stafilococo aureus meticilino resistente (SAMR)el 26,4 %. El tratamiento antibiótico empírico y el tratamiento definitivo se basó en cefalosporinas de primera generación en 83 % y 52,7% de los casos, respectivamente. La principal complicación fue la sepsis en 18 (25 %) pacientes. Conclusiones: se debe tener un alto índice de sospecha, no todos los pacientes se presentan con síntomas o signos típicos. El patógeno principal es el Staphylococcus aureus. En los últimos 10 años ha aumentado la incidencia de las infecciones por SAMR en nuestra institución en relación con estudios previos. Notamos una demora en el diagnóstico y, por ende, en el inicio del tratamiento.

SUMMARY Introduction: The main pathogen in osteoarticular infections is Staphylococcus aureus. The recommended treatment schemes are based on American or European literature, there are no data from local studies. The purpose of this study is to know the epidemiological profile in osteoarticular infections of the San Vicente Fundación children's hospital (Medellín/Colombia) and the characteristics of the affected patients. Materials and methods: Retrospective review of histories of patients between 0 and 15 years old with a diagnosis of osteoarticular infection in the San Vicente Fundación children's hospital detailing demographic variables, pathology and relevant antecedents to characterize the epidemiological profile of osteoarticular infections in the hospital. Results: We identified 72 patients with osteoarticular infection. The most common septic arthritis infection (40%) followed by acute osteomyelitis (37%), the most affected joint was the hip (18%) and the most affected bone was the tibia (31%). The majority of infections were secondary to S. aureus (65%) of which were by SAMS 38.9% and by SAMR 26.4%. Empirical as well as definitive antibiotic treatment was based on first generation cephalosporins 83% and 52.7% respectively. The main complication was sepsis in 18 (25%) patients. Conclusions: There must be a high index of suspicion, not all patients present with typical symptoms and / or signs. The main pathogen Staphylococcus aureushas increased the incidence of MRSA infections in our institution in the last 10 years in relation to previous studies. We note delay in diagnosis and therefore in the start of treatments.

Double femoral osteotomy for the treatment of severe sequelae of the immature hip / Dupla osteotomia do fêmur para o tratamento de graves sequelas no quadril imaturo

ABSTRACT Objective: To evaluate the results of double femoral osteotomy for the treatment of severe sequelae of the hip. Methods: Immature patients with anatomical loss of the hip were treated with pelvic support osteotomy in the distal femur to correct lower limb shortening, they were evaluated clinically and radiographically. Results: Eleven cases (eleven hips) were assessed with verage follow-up of three years. The mean age of the patients was 14.7 years. Seven patients had sequela of infectious arthritis; three had sequela of developmental dysplasia of the hip and one patient had a sequela of slipped capital femoral epiphysis. Preoperatively, the gluteus medius was insufficient in all patients, and it became negative in ten of them. The average of lower limb shortening was 5 cm (2.5 to 7 cm) and reduced shortening was 1.9 cm (0 to 4 cm). According to Paley Classification, 72.7% of complications were considered problems, 90.9% were considered obstacles and 27.2% complications, among which the limitation of the knee flexion was the most frequent. Conclusion: The technique yielded good results, considering the severity of the sequela and the absence of a better therapeutic option. No important sequela was associated with the treatment. Level of Evidence IV, Case series.

RESUMO Objetivo: Avaliar os resultados do tratamento de graves sequelas do quadril pela dupla osteotomia do fêmur. Métodos: Pacientes imaturos, com perda da articulação do quadril, foram tratados com osteotomia de apoio pélvico associada à osteotomia na região distal do fêmur para correção do eixo do membro inferior e do encurtamento, foram avaliados clínica e radiograficamente. Resultados: Onze casos (onze quadris) foram avaliados, com seguimento médio de três anos. A média de idade no tratamento foi de 14,7 anos. Sete indivíduos tinham sequela de artrite séptica, três de displasia do desenvolvimento do quadril e um de escorregamento epifisário proximal do fêmur. Pré-operatoriamente, a marcha por insuficiência do glúteo médio esteve presente em todos os sujeitos e se tornou negativa em dez deles. O encurtamento médio inicial do membro afetado foi de 5 cm (2,5 a 7 cm) e o reduzido teve média de 1,9 cm (0 a 4 cm). Segundo classificação de Paley, 72,7% apresentaram intercorrências consideradas problemas, 90,9% obstáculos e 27,2% complicações, entre as quais a limitação da amplitude de movimento do joelho foi a mais frequente. Conclusão: A técnica produziu bons resultados em face da gravidade da sequela e da falta de outra opção terapêutica melhor. Não houve sequela importante associada ao tratamento. Nível de Evidência IV, Série de casos.

Acometimento pulmonar e articular secundário à síndrome de Lemierre: relato de caso e revisão de literatura / Pulmonary and joint involvement secondary to Lemierre syndrome: case report and literature review

A síndrome de Lemierre caracteriza-se por uma rara entidade que gera tromboflebite da veia jugular interna e embolismo séptico em história da infecção recente da orofaringe, além de sinais radiológicos e isolamento de patógenos anaeróbicos, principalmente Fusobacterium necrophorum. Relatamos o caso de uma paciente do sexo feminino, 13 anos de idade, com histórico de carcinoma de nasofaringe associado ao vírus Epstein-Barr (estadiamento T4N2M0), submetida a procedimentos cirúrgicos e quimiorradioterapia. Iniciou com queixa de mialgia intensa, diplopia, lesões infectadas em membros e choque séptico. Por meio de exames de ultrassonografia cervical com Doppler colorido e tomografia computadorizada de pescoço com contraste endovenoso, foram identificados trombos intraluminais na veia jugular interna, além de trombos sépticos pulmonares, por meio da tomografia computadorizada de tórax. Posteriormente, ainda evoluiu com artrite piogênica coxofemoral esquerda. Foi isolada, por hemocultura, a bactéria Klebsiella pneumoniae Carpemenase, e o tratamento se deu pela associação entre vancomicina, amicacina, meropenem, metronidazol e anfotericina B. Conclui-se que, após o diagnóstico de SL e, embora com múltiplas complicações e diagnóstico tardio, a paciente encontra-se bem e assintomática, além do relato comprovar a dificuldade diagnóstica e de seu tratamento

Lemierre's syndrome is a rare condition that leads to thrombophlebitis of the internal jugular vein and septic embolism following recent oropharyngeal infection, being characterized by radiological signs and isolation of anaerobic pathogens, especially Fusobacterium necrophorum. We report the case of a 13-year-old female patient with history of nasopharyngeal carcinoma associated with Epstein-Barr virus (T4N2M0 staging), who underwent surgical procedures and chemoradiotherapy. Her initial complaint was severe myalgia, diplopia, infected limb injuries, and septic shock. Cervical color Doppler ultrasound and computed tomography scan of the neck with intravenous contrast showed intraluminal thrombi in the internal jugular vein, and chest computed tomography showed pulmonary septic thrombi. Subsequently, she progressed with left coxofemoral pyogenic arthritis. The bacterium Klebsiella pneumoniae Carpemenase was isolated in blood culture, and the patient was treated with the association of vancomycin, amikacin, meropenem, metronidazole, and amphotericin B. It is concluded that, despite the multiple complications and late diagnosis, the patient is well and asymptomatic after the diagnosis of Lemierre's syndrome; in addition, the report proves the difficulty of diagnosis and treatme

Present situation and prospect of diagnosis and treatment of periprosthetic joint infections / 中华外科杂志

Periprosthetic joint infection (PJI) as an insurmountable challenge has always represented a serious concern for orthopedic surgeons. Accurate diagnosis and reasonable treatment of PJI are the keys to deal with this challenge.The diagnosis of PJI is mainly based on clinical manifestations, joint fluid biochemistry, pathogen culture and biomarkers at present. New pathogen culture methods and specific biomarkers in recent years are hot topics in PJI research. In terms of treatment, two-stage revision is still considered to be the 'gold standard’ protocol. However, more and more centers around the world have begun to accept and try one-stage revision as a treatment for PJI.

Artritis séptica de la rodilla / Septic arthritis of the knee

RESUMEN Fundamento: la artritis séptica es una enfermedad devastadora que provoca secuelas funcionales y en ocasiones la muerte del enfermo, la articulación de la rodilla es una de las más afectadas. Objetivo: actualizar los conocimientos en relación a la artritis séptica de la rodilla. Métodos: la búsqueda de la información se realizó en un periodo de dos meses (primero de noviembre de 2017 al 31 de diciembre de 2017) y se emplearon las siguientes palabras: septic arthritsis of the knee, knee septic arthritis, y septic arthritis, a partir de la información obtenida se realizó una revisión bibliográfica de un total de 953 artículos publicados en las bases de datos PubMed, Hinari, SciELO y Medline mediante el gestor de búsqueda y administrador de referencias EndNote, de ellos se utilizaron 50 citas seleccionadas para realizar la revisión, 48 de los últimos cinco años, se incluyeron ocho libros. Desarrollo: se exponen los factores de riesgo para sufrir esta enfermedad, tanto en adultos como en niños. Se muestran los gérmenes patógenos más frecuentes responsables de la infección, así como las vías de su llegada al tejido sinovial. Se abordan las principales manifestaciones clínica, imaginológicas, microbiológicas e histológicas. Se hace referencia a las ventajas de la vía artroscópica sobre la artrotomía. Se exponen los factores de mal pronóstico, así como las complicaciones. Conclusiones: la artritis séptica de rodilla necesita de un diagnóstico y conducta inmediata, dentro de las variantes quirúrgicas la artroscopia ofrece ventajas sobre la artrotomía, en especial en lo referente a función articular y estética.

ABSTRACT Background: septic arthritis is a devastating disease, which may cause functional impairment and sometimes the patient´s death, the knee joint is one of the most affected. Objective: to update the knowledge about septic arthritis of the knee. Methods: a search in the databases PubMed, Hinari, SciELO and Medline was done through the information locator EndNote by using the words septic arthritis of the knee, knee septic arthritis, and septic arthritis, resulting in a total of 953 articles, 50 of them were selected for review, 48 of them of the last five years and eight books were included. Development: risk factors in adults and children were exposed. The most common organisms causing septic arthritis were shown, as well as the way to reach synovial tissue. The main Clinical, imaging, histology and microbiology manifestation were pointed out. Advantages of arthroscopic treatment over arthrotomy were stated. Factors related to poor prognosis and complications were exposed. Conclusions: septic arthritis of the knee needs an early diagnosis to begin treatment as soon as possible. Arthroscopic treatment is better than arthrotomy in regards to articular function and esthetics.

Epidemiological study of osteoarticular infections in children / Estudo epidemiológico das infecções osteoarticulares em crianças

ABSTRACT Objective To analyze the characteristics of patients diagnosed with pediatric osteoarticular infections treated in a level III trauma center in São Paulo, Brazil. Methods We retrospectively analyzed patients admitted between September 2012 and August 2014. The outcomes analyzed were: age, sex, diagnosis, etiologic agent, anatomic location, time to diagnosis, history of previous trauma and infection, laboratory tests, treatment, and complications. Results Twenty patients were included, 50% with septic arthritis, 35% with osteomyelitis, and 15% with both. Boys were predominant (80%), and the mean age was 6.6 years. The most common etiologic agent was Staphylococcus aureus. C-reactive protein value and erythrocyte sedimentation rate were elevated. The infections were treated with antibiotic therapy (intravenous and oral) and oxacillin was most frequently used. Most patients underwent at least one surgical procedure, and 35% of patients had complications. Conclusion This epidemiological mapping identified clinical and demographic characteristics which are useful for improving preparation for care. Future prospective studies with longer patient follow-up and the development of treatment protocols are needed to improve therapeutic decision-making and the prognosis of children with suspected osteoarticular infections. Evidence Level II; Prognostic studies - Investigation of the effect of patient characteristics on the outcome of the disease.

RESUMO Objetivo analisar as características dos pacientes com diagnóstico de infecção osteoarticular pediátrica, tratados em um hospital de nível terciário em São Paulo. Métodos Analisamos, retrospectivamente, os pacientes internados no período entre setembro de 2012 e agosto de 2014. As variáveis analisadas foram: idade, gênero, diagnóstico, agente etiológico, localização anatômica, tempo de diagnóstico, histórico de infecção e trauma prévio, exames laboratoriais, tratamento e complicações. Resultados 20 pacientes foram incluídos, 50% com artrite séptica, 35% osteomielite e 15% ambos. Houve predomínio do gênero masculino (80%), média de idade de 6,6 anos. O agente etiológico mais comum foi o Staphiloccocus aureus. Ambos os exames laboratoriais PCR e VHS aumentaram. O tratamento foi a antibioticoterapia (via endovenosa e oral) e a oxacilina foi o medicamento mais utilizado. A maioria dos pacientes foram submetidos ao menos a um procedimento cirúrgico e 35% dos pacientes apresentaram complicações. Conclusão Este mapeamento epidemiológico identificou características clínicas e demográficas úteis para melhorar o preparo da equipe para o atendimento. Pesquisas futuras de caráter prospectivo, com maior tempo de acompanhamento dos pacientes e a elaboração de protocolos de atendimento são necessárias para melhorar a tomada de decisão terapêutica e o prognóstico de crianças com suspeita de infecção osteoarticular. Nível de Evidência II; Estudos prognósticos - Investigação do efeito de característica de um paciente sobre o desfecho da doença.

Chronic polyarthritis as the first manifestation of childhood systemic polyarteritis nodosa / Poliartrite crônica como primeira manifestação de poliarterite nodosa sistêmica pediátrica

ABSTRACT Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. We describe the case of a 4-year old girl who had additive and chronic polyarthritis with edema, tenderness, pain on motion and morning stiffness for 2 months. After 45 days, she also presented painful subcutaneous nodules and erythematous-violaceous lesions in the extensor region of upper and lower limbs. She was admitted to university hospital due to high fever, malaise, myalgia, anorexia, loss of weight (1kg), painful skin lesions and severe functional disability. She was bedridden by chronic polyarthritis with limitation on motion. Systolic and diastolic blood pressures were greater than 95th percentile for height. Urine protein/creatinine ratio was 0.39g/day, and immunological tests were negative. Anti-streptolysin O was 1,687UI/mL. Skin biopsy revealed necrotizing vasculitis in medium- and small-sized vessels compatible with polyarteritis nodosa. Therefore, we had the diagnosis of systemic polyarteritis nodosa. Prednisone 2mg/kg/day was administered with complete resolution of skin lesions and arthritis, and improvement of proteinuria (0.26g/day) after 15 days. The diagnosis of childhood systemic polyarteritis nodosa should be considered for patients with chronic polyarthritis associated to cutaneous vasculitis triggered by streptococcal infection.

RESUMO Na poliarterite nodosa sistêmica pediátrica, a artrite caracteriza-se pelo padrão agudo, geralmente evanescente, com oligoartrite, e afeta principalmente joelhos e tornozelos. No entanto, a poliartrite crônica com rigidez matinal e simulando artrite idiopática juvenil ainda não foi relatada. Descrevemos o caso de uma menina de 4 anos que apresentou poliartrite crônica aditiva com edema, dor à palpação e movimento, e rigidez matinal por 2 meses. Após 45 dias, também apresentou nódulos subcutâneos dolorosos e lesões eritêmato-violáceas na região extensora dos membros superiores e inferiores. Foi internada no hospital universitário por conta de febre alta, mal-estar, mialgia, anorexia, perda de peso (1kg), lesões de pele muito dolorosas e incapacidade funcional grave. Estava restrita ao leito devido à poliartrite crônica com limitação do movimento. Pressões sistólica e diastólica foram maiores que percentil 95 para altura. Relação proteína/creatinina urinária estava 0,39g/dia, e os testes imunológicos foram negativos. Antiestreptolisina O era 1.687UI/mL. A biópsia de pele revelou vasculite necrosante de vasos de pequeno e médio calibre, compatível com poliarterite nodosa. Portanto, foi realizado o diagnóstico de poliarterite nodosa sistêmica. Foi administrada prednisona 2mg/kg/dia com resolução completa das lesões de pele e da artrite, além de melhora da proteinúria (0,26g/dia) após 15 dias. O diagnóstico de poliarterite nodosa sistêmica pediátrica deve ser considerado em pacientes com poliartrite crônica associado a lesões cutâneas vasculíticas, sendo a infecção estreptocócica um importante fator desencadeante.

Analysis on the arthroscopy efficacy with different irrigation times for the treatment of suppurative knee arthritis in elder patients / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the curative effect of arthroscopy-assisted irrigation with different times for the treatment of suppurative knee arthritis in elder patients.</p><p><b>METHODS</b>From October 2012 to October 2014, 23 old patients with suppurative knee arthritis were treated with arthroscopic debridement and continuous irrigation. All the patients were randomly divided into two groups:one-week irrigation group (10 cases) and two-week irrigation group(13 cases). The ESR, CRP, recovery time of knee skin temperature, joint rang of motion and knee function were observed to evaluate the therapeutic effects.</p><p><b>RESULTS</b>All the patients were followed up, and the mean duration was(13.3±2.3) months. No recurrence was observed. The CRP in both groups returned to normal level 2 weeks after operation. The ESR in two-week irrigation group returned to normal level 2 weeks after operation, while in one-week irrigation group it was still at a high level, and returned to normal level 3 weeks after operation; there was a statistical significance between these two groups(<0.05). The recovery time of knee skin temperature after operation in two-week irrigation group was (13.4±1.2) d on average(ranged, 8 to 17 d), which was less than(15.5±1.9) d on average(ranged, 10 to 20 d) in one-week irrigation group (<0.05). The knee joint mobility of all patients 1, 3, 6 months after operation was significantly improved compared with those before surgery(<0.05). The knee joint mobility of patients in two-week irrigation group was better than that in one-week irrigation group at the first month after operation(<0.05);but there were no significant differences between these two groups 3, 6 months after operation. The Lysholm score of all patients 1, 3, 6 months after operation was significantly improved compared with those before surgery(<0.05). The Lysholm score of patients in two-week irrigation group was better than in one-week irrigation group at the first month after operation(<0.05);but there were no significant differences between these two groups 3, 6 months after operation. All the patients had stable knee functions 3 months after operation. According to the Lysholm scale, 3 patients got an excellent result, 6 good and 1 poor in one-week irrigation group 6 months after operation;5 patients got an excellent result, 7 good and 1 poor in two-week irrigation group;there was no significant differences between these two groups.</p><p><b>CONCLUSIONS</b>Treatment of suppurative knee arthritis using arthroscopy has such advantages as minimal invasion and complete debridement, which is helpful to attenuate inflammation and regain knee function. It is suggested that the irrigation should be prolonged for two weeks postoperatively.</p>

Septic Arthritis Caused by Bacteroides thetaiotaomicron Bacteremia in a Patient with Multiple Myeloma / 대한내과학회지

Septic arthritis is rarely caused by anaerobic bacteria, which is mostly secondary to hematogenous dissemination among the immunocompromised host. We report a patient of septic arthritis on the right knee joint caused by Bacteroides thetaiotaomicron. To the best of knowledge, this is the first report of septic arthritis caused by Bacteroides spp. in Korea.

Antibiotic Spacers in Shoulder Arthroplasty: Comparison of Stemmed and Stemless Implants

BACKGROUND: Antibiotic spacers in shoulder periprosthetic joint infection deliver antibiotics locally and provide temporary stability. The purpose of this study was to evaluate differences between stemmed and stemless spacers. METHODS: All spacers placed from 2011 to 2013 were identified. Stemless spacers were made by creating a spherical ball of cement placed in the joint space. Stemmed spacers had some portion in the humeral canal. Operative time, complications, reimplantation, reinfection, and range of motion were analyzed. RESULTS: There were 37 spacers placed: 22 were stemless and 15 were stemmed. The stemless spacer population was older (70.9 ± 7.8 years vs. 62.8 ± 8.4 years, p = 0.006). The groups had a similar percentage of each gender (stemless group, 45% male vs. stemmed group, 40% male; p = 0.742), body mass index (stemless group, 29.1 ± 6.4 kg/m² vs. stemmed group, 31.5 ± 8.3 kg/m²; p = 0.354) and Charlson Comorbidity Index (stemless group, 4.2 ± 1.2 vs. stemmed group, 4.2 ± 1.7; p = 0.958). Operative time was similar (stemless group, 127.5 ± 37.1 minutes vs. stemmed group, 130.5 ± 39.4 minutes). Two stemless group patients had self-resolving radial nerve palsies. Within the stemless group, 15 of 22 (68.2%) underwent reimplantation with 14 of 15 having forward elevation of 109°± 23°. Within the stemmed group, 12 of 15 (80.0%, p = 0.427) underwent reimplantation with 8 of 12 having forward elevation of 94°± 43° (range, 30° to 150°; p = 0.300). Two stemmed group patients had axillary nerve palsies, one of which self-resolved but the other did not. One patient sustained dislocation of reverse shoulder arthroplasty after reimplantation. One stemless group patient required an open reduction and glenosphere exchange of dislocated reverse shoulder arthroplasty at 6 weeks after reimplantation. CONCLUSIONS: Stemmed and stemless spacers had similar clinical outcomes. When analyzing all antibiotic spacers, over 70% were converted to revision arthroplasties. The results of this study do not suggest superiority of either stemmed or stemless antibiotic spacers.

Septic arthritis and arthropathy of the rotator cuff: remember this association / Artrite séptica e artropatia do manguito rotador: lembrar-se dessa associação

ABSTRACT OBJECTIVE: To describe occurrences of septic glenohumeral arthritis among patients with arthropathy of the rotator cuff, and to highlight the importance of correct diagnosis and surgical procedures. METHODOLOGy: Eight surgical drains were installed in seven patients with glenohumeral pyoarthritis. All the patients presented arthropathy of the rotator cuff (four males and three females). Six patients presented pyoarthritis in the dominant shoulder. The age range was from 53 to 93 years (mean: 74 years). The mean duration of the symptoms before the surgical lavage was six weeks. Six patients underwent treatment consisting of a combination of arthroscopic irrigation and debridement, and one patient was treated by means of open arthrotomy. All the patients received systemic antibiotic therapy in accordance with their bacterial sensitivity. RESULTS: All seven patients achieved satisfactory results, taking into consideration especially the improvement of pain and the patients' satisfaction. The functional assessment was performed using the University of California Los Angeles (UCLA) scale. Only one patient needed to go through another arthroscopic procedure. Staphylococcus aureus was isolated from four cultures and Escherichia coli from one culture. There were two situations in which the patients used empirical antibiotic therapy and the cultures showed negative results. Among the associated procedures, tenotomy of the biceps was performed in four cases, resection of the lateral third of the clavicle due to osteomyelitis in one case and arthrotomy of the knee in one case. CONCLUSION: Surgical treatment was effective in the cases of arthritis associated with arthropathy of the rotator cuff. In patients with arthropathy of the rotator cuff and subclinically altered laboratory signs, the possibility of pyoarthritis should always be suspected.

RESUMO OBJETIVO: Descrever a ocorrência de artrite séptica glenoumeral em pacientes com artropatia do manguito rotador, bem como destacar a importância do correto diagnóstico e procedimento cirúrgico. METOLOGIA: Foram feitas oito drenagens cirúrgicas em sete pacientes com pioartriteglenoumeral. Todos os pacientes apresentavam artropatia do manguito rotador (quatro do sexo masculino e três do feminino). Seis pacientes apresentavam pioartrite no ombro dominante, a idade variou de 53 a 93 anos (média de 74 anos). A duração media dos sintomas antes da lavagem cirúrgica foi de seis semanas. Seis pacientes foram submetidos ao tratamento com a combinação de irrigação artroscópica e desbridamento, um paciente foi tratado por artrotomia aberta. Todos os pacientes receberam antibioticoterapia sistêmica de acordo com a sensibilidade bacteriana. RESULTADOS: Os sete pacientes obtiveram resultados satisfatórios, se levarmos em consideração principalmente a melhoria da dor e a satisfação dos pacientes. A avaliação funcional foi feita por meio da escala da Universidade da Califórnia em Los Angeles (UCLA). Apenas um paciente precisou passar por um novo procedimento artroscópico, em quatro culturas foi isolado o Staphylococcus aureus, em uma cultura a Escherichia coli e em duas situações, nas quais os pacientes usavam antibioticoterapia empírica, essas culturas tiveram resultado negativo. Entre os procedimentos associados fez-se quatro tenotomias do bíceps, uma ressecção do 1/3 lateral da clavícula devido àosteomielite e uma artrotomia do joelho. CONCLUSÃO: O tratamento cirúrgico foi eficaz nos casos de artrite associada a artropatia do manguito rotador. Sempre suspeitar, em pacientes com artropatia do manguito rotador com sinais subclínicos e laboratoriais alterados, da possibilidade de uma pioartrite.

Artritis séptica del hombro: a propósito de un caso / Septic arthritis of the shoulder: a case report

Fundamento: la artritis séptica del hombro, aunque presenta la misma fisiopatología de otras articulaciones, es una enfermedad infrecuente. Objetivo: presentar el caso de un paciente con artritis séptica del hombro. Caso clínico: paciente masculino de 70 años. El paciente acudió a la consulta de urgencia de ortopedia y traumatología por presentar dolor e incapacidad funcional del hombro derecho, después de haber sido intervenido en cirugía menor por una lesión de piel hacía siete días. En la exploración física se apreció aumento de volumen marcado en la articulación del hombro derecho, acompañado de limitación del arco de movimiento articular. Mediante la palpación se constató aumento de la temperatura local de la articulación. En el examen ultrasonográfico de urgencia se detectó la presencia de gran cantidad de líquido en la articulación glenohumeral. Al paciente se le diagnosticó artritis séptica del hombro derecho y se le indicó tratamiento quirúrgico. Conclusiones: la artritis séptica del hombro es una enfermedad infrecuente; el tratamiento indicado es el quirúrgico que consiste en el lavado y desbridamiento de la articulación.

Background: although septic arthritis of the shoulder has the same physiopathology of other joints, it is an infrequent condition. Objective: to present the case of a patient with septic arthritis of the shoulder. Case report: a seventy-year-old white male patient. The patient came to the orthopedic emergency department for presenting pain and physical disability in the right shoulder after undergoing a minor surgery for a skin lesion seven days before. In the physical examination, marked increased volume in the joint of the right shoulder could be found, associated with limitations in the articular movement arc. Palpation revealed increased local temperature. The emergency ultrasonographic examination showed a great quantity of liquid inside the glenohumeral joint. The patient was diagnosed with septic arthritis of the right shoulder and surgical treatment was indicated. Conclusions: septic arthritis of the shoulder is an infrequent condition. Surgical treatment, consisting in articular wash and debridement, is indicated.

An atypical spondylodiscitis: case report / Uma espondilodiscite atípica: relato de caso

Spondylodiscitis is a rare pathology, however its incidence has been rising in recent years. Its signs and symptoms are nonspecific therefore the diagnosis may be delayed from 2 to 6 months. The main symptom is back or neck pain but some patients may experience no pain. The authors report the case of an 82 year old man with a presentation of initial cough, followed by monoarthritis, then polyarthritis and finally paraparesis, accompanied by fever and elevation of infection markers. The insidious evolution delayed the diagnosis of spondylodiscitis as well as its treatment. The identified pathogen was Streptococcus pneumoniae, a very rare cause of spondylodiscitis. After 6 weeks of antibiotics the patient was discharged. Spondylodiscitis diagnosis requires a high level of suspicion due to its wide range of clinical presentations and must be ruled out when we are faced with a fever of unknown origin or an inappropriate response to treatment.

A espondilodiscite é uma patologia rara, porém sua incidência tem vindo a aumentar nos últimos anos. Os seus sinais e sintomas não são específicos e, como tal, o diagnóstico pode ser atrasado de 2 a 6 meses. O principal sintoma é a dor nas costas ou no pescoço, mas alguns doentes podem não apresentar dor. Os autores relatam o caso de um homem de 82 anos, com uma apresentação inicial de tosse, seguida de monoartrite, depois poliartrite, e finalmente paraparésia, acompanhado de elevação dos parâmetros de infecção. A evolução insidiosa atrasou o diagnóstico de espondilodiscite, assim como o seu tratamento. O patogénio identificado foi Streptococcus pneumoniae, uma causa bastante rara de espondilodiscite. Após 6 semanas de anti-bioterapia o doente teve alta. A espondilodiscite é um diagnóstico que requer um alto nível de suspeição dada a ampla variedade de apresentações clínicas e deve ser excluída quando estamos perante um caso de febre de origem indeterminada ou uma resposta inadequada ao tratamento.

Artritis infecciosa de la articulación temporomandibular consecutivo a otitis necrotizante: reporte de un caso / Septic arthritis of the temporomandibular joint: Report of one case

Septic arthritis of the temporomandibular joint (TMJ) is an uncommon condition, caused by hematic bacterial migration or direct migration of other head and neck infections. We report a 41 year old female who presented a right temporomandibular joint involvement, with bone destruction of the mandibular condyle and an infectious process spreading to the temporal space, following a necrotizing medial and external otitis with associated mastoiditis. A septic arthritis of the TMJ by continuity was diagnosed and treated with antimicrobials, TMJ arthrocentesis and occlusal stabilization, with a positive evolution. However, the patient remains in control due a secondary TMJ osteoarthritis caused by the septic arthritis.

Application of a Novel Diagnostic Rule in the Differential Diagnosis between Acute Gouty Arthritis and Septic Arthritis

Septic arthritis and gout are major diseases that should be suspected in patients with acute monoarthritis. These two diseases are clinically similar and often indistinguishable without the help of synovial fluid analysis. Recently, a novel diagnostic rule for gout without synovial fluid analysis was developed and showed relevant performances. This study aimed to determine whether this diagnostic rule could perform well in distinguishing gout from septic arthritis. The diagnostic rule comprises 7 clinical and laboratory variables, each of which is given a specified score. The probability of gout is classified into 3 groups according to the sum of the scores: high (> or = 8), intermediate (> 4 to < 8) and low probability (< or = 4). In this retrospective study, we applied this diagnostic rule to 136 patients who presented as acute monoarthritis and were subsequently diagnosed as acute gout (n = 82) and septic arthritis (n = 54) based on synovial fluid analysis. The mean sum of scores of acute gout patients was significantly higher than that of those with septic arthritis (8.6 +/- 0.2 vs. 3.6 +/- 0.32, P < 0.001). Patients with acute gout had significantly more 'high', and less 'low' probabilities compared to those with septic arthritis (Eta[eta]: 0.776). The prevalence of acute gouty arthritis, as confirmed by the presence of monosodium crystal, was 95.5% (61/64), 57.5% (19/33), and 5.1% (2/39) in high, intermediate and low probability group, respectively. The recently introduced diagnostic rule properly discriminates acute gout from septic arthritis. It may help physicians diagnose gout in cases difficult to be differentiated from septic arthritis.

Acute Septic Arthritis and Skin Abscess Caused by Neisseria cinerea / 이화의대지

Neisseria cinerea is bacteria known as non-pathogenic strain. However, in rare cases, it can cause opportunistic infections. Those diseases caused by N. cinerea include neonatal ophthalmia, proctitis, pneumonia, peritonitis in patients with continuous ambulatory peritoneal dialysis, endocarditis and meningitis. In this report, we describe a patient with septic arthritis and skin abscess of finger joints that was caused by N. cinerea. A 27-year-old man visited the hospital due to swelling, redness and pain of proximal interphalangeal joint of the left second finger. After blood culture test, ceftriaxone was administered on admission and debridement was performed the affected joints. N. cinerea was identified in the blood culture. The patient was improved with ceftriaxone.