ABSTRACT
Cardiac glycosides are proven to be effective in the clinical treatment for chronic heart failure and certain types of arrhythmia, especially for antitumor treatment. This paper focused on the research progress on pharmacokinetics of cardiac glycosides in recent years, elucidated the behaviors of absorption, distribution, metabolism, and excretion in vivo and in vitro, and summarized the metabolism of this kind of drug, aiming to provide an evidence for new drug research as well as a reference for the clinical safe use of these drugs.
ABSTRACT
102 causes of heart arythmia were treated at Kien An General Hospital - Hai Phong from January 2002 to October 2002. There was no difference between male and female subjects in the prevalence of heart arythmia. Its predominance was at the age group above 51 years old. Sinusal tachyarythmia and atrial fibrillation were prevailed among all types. Rheumatism valvular disease, blood hypertension were the most common condition and primary causes of atrial fibrillation and combines arythmia. Chronical cardio-pulmonary diseases and diverse shocks were the second rank of leading causes. Left branch blockade and ventricle tachyrythmia of patients with IV degree of heart failure were nearly severe prognostic factors. Mortality was very high with ventricle failure.