Effect of recombinant human coagulation factor Ⅶa combined with Bakri balloon compression on oxidative stress and coagulation in patients with refractory postpartum hemorrhage / 中国输血杂志

【Objective】 To investigate the effects of recombinant human coagulation factor Ⅶa combined with Bakri balloon compression on oxidative stress and coagulation in patients with refractory postpartum hemorrhage. 【Methods】 Prospectively, 80 patients with refractory postpartum hemorrhage in Chengdu Fifth People′s Hospital from June 2019 to June 2022 were selected and grouped according to the random number table method. The control group (n=40) was treated with Bakri balloon compression, and the observation group (n=40) was treated with recombinant human coagulation factor Ⅶa combined with Bakri balloon compression. The bleeding-related indexes and adverse effects were observed in both groups, and the prenatal and 24 h postpartum oxidative stress, coagulation function and inflammatory factors were compared between the two groups. 【Results】 The blood loss in the observation group and the control group was (683.96±146.52) vs(796.63±152.41)mL during operation, (812.46±161.53) vs(965.39±166.22)mL in 2 h after delivery, (899.53±178.74) vs(1 084.31±203.67)mL in 24 h after delivery, and the transfusion volume was (512.31±104.76) vs(683.25±113.52)mL, and the onset time of hemostasis was (14.63±3.18) vs (21.72±5.29) min (P0.05). At 24 h postpartum, NE, Cor, SOD and MDA were higher than those before delivery in both groups, but the observation group was lower than the control group (P<0.05); TT, APTT and PT were longer and Fib was lower in both groups than before delivery, but TT, APTT and PT were shorter and Fib was higher in the observation group than in the control group (P<0.05); CRP, IL-8 and TNF-α were higher in both groups than before delivery, but the observation group was lower than in the control group (P<0.05). 【Conclusion】 Hemostasis in patients with refractory postpartum hemorrhage treated with recombinant human coagulation factor Ⅶa combined with Bakri balloon compression was effective, which can improve coagulation, reduce transfusion, decrease oxidative stress injury and inflammatory response without increasing adverse effects.

Balón de Bakri en el control de la hemorragia obstétrica. Experiencia de cinco años / Bakri's balloon in the control of obstetric hemorrhagia. Five years experiencie

Resumen OBJETIVO: Evaluar los desenlaces con la aplicación del balón de Bakri para contener la hemorragia posparto. MATERIALES Y MÉTODOS: Estudio descriptivo, analítico, observacional y retrospectivo efectuado en pacientes atendidas en el Hospital Central, San Luis Potosí, a quienes de enero 2012 a diciembre 2017 se les colocó un balón de Bakri para contener la hemorragia posparto. Se excluyeron los expedientes incompletos y las pacientes a quienes se colocó el balón en otra institución. El análisis estadístico se procesó en una hoja de Excel Office 2013. RESULTADOS: Se realizaron 143 colocaciones del balón de Bakri, 84.06% (n = 121) durante el posparto, 9% (n =13) en la poscesárea y 6.2% (n = 9) durante la cesárea. La colocación del balón se consideró exitosa en 90.2% (n = 129); hubo 14 (9.79%) fallas en el control de la hemorragia que ameritaron otro procedimiento. El 48.9% de las pacientes no tenían factores de riesgo. El promedio de permanencia del balón fue de 20 h. Se registró una muerte obstétrica directa, por choque hipovolémico. CONCLUSIONES: El éxito del balón de Bakri para contener la hemorragia obstétrica fue similar al reportado en la bibliografía. Su aplicación es una estrategia de segunda línea, secundaria a atonía y complicaciones bajas.

Abstract OBJECTIVE: To evaluate the outcomes with the application of the Bakri balloon to contain postpartum hemorrhage. MATERIALS AND METHODS: Descriptive, analytical, observational and retrospective study carried out in patients attended at the Central Hospital in San Luis Potosi who between the months of January 2012 to December 2017 had a Bakri balloon placed to contain postpartum hemorrhage. Incomplete records and patients who had the balloon placed in another institution were excluded. Statistical analysis was processed in an Excel Office 2013 spreadsheet. RESULTS: 143 Bakri balloon placements were performed, 84.06% (n = 121) during postpartum, 9% (n =13) post cesarean section and 6.2% (n = 9) during cesarean section. Balloon placement was considered successful in 90.2% (n = 129); there were 14 (9.79%) failures to control bleeding that warranted another procedure. Of the patients, 48.9% had no risk factors. The average length of stay was 20 hours. One direct obstetric death was recorded, due to hypovolemic shock. CONCLUSIONS: The success of the Bakri Balloon in containing obstetric hemorrhage was similar to that reported in the literature. Its application is a second line strategy, secondary to atony and low complications.

Successful reduction of acute puerperal uterine inversion with use of Bakri postpartum balloon

Acute puerperal inversion is rare but potentially fatal obstetric emergency and prompt recognition will enable immediate repositioning of uterus before it becomes edematous and incarcerated. Manual repositioning along with use of uterine balloon tamponade is simple and effective way for repositioning of inverted uterus as well as prevention of recurrence.

Bakri postpartum balloon: an obstetrician’s armamentarium in managing post-partum haemorrhage

Background: Post-partum haemorrhage (PPH), an obstetric emergency that can complicate vaginal or cesarean deliveries and associated with serious complications. Guidelines for the management of PPH involve a stepwise escalation of pharmacological and eventual surgical approaches. In women who do not respond to uterotonics or medical treatment, a variety of procedures, such as arterial embolization, surgical ligation of the uterine arteries or obstetric hysterectomy, may be used. The Bakri balloon is an intrauterine device indicated to reduce or control PPH temporarily when conservative treatment is warranted. Here, we are presenting case series of primary atonic PPH and which were managed by Bakri Balloon Tamponade (BBT).Methods: This case series included five women with PPH managed by Bakri balloon as a conservative therapeutic option.Results: All five women were in age group between 23 years to 34 years. The causes of PPH were uterine atony, retained placenta and central placenta previa. The Bakri balloon was successful in controlling hemorrhage in all women (five of five) who did not respond to medical uterotonic treatment.Conclusions: Bakri balloon is a simple, easy to use and effective method for conservative management of acute PPH. This device reduces bleeding, shortens the hospital stay and avoids the need for more aggressive procedures.

A study of the efficacy and safety of the balloon tamponade in the management of atonic post-partum hemorrhage

Background: The most common cause of post-partum hemorrhage (PPH) is uterine atony. Treatment for atony follows a well-defined stepwise approach, including drugs and mechanical interventions followed by surgery as a last resort. Early use of intrauterine balloon tamponade is a way of limiting ongoing uterine blood loss while initiating other measures and can be readily implemented by providers with minimal training.Methods: This prospective interventional study was conducted in 112 consecutive patients attended department of obstetrics and gynecology, Gandhi Medical College and Associated Sultania Zanana Hospital, Bhopal, Madhya Pradesh, India, in one year of study period.Results: In this study most of the patients had gestational age >37 weeks [83 (74.1%)]. Most of the patients in the study had vaginal delivery [64 (57.1%)]. In 84 (75%) patients Bakri balloon was used followed by Burke balloon in 17 (15.2%) patients, condom catheter in 7 (6.2%) patients and CG balloon in 4 (3.6%) patients. Different types of balloons were used according to availability of balloon at the time of management. Most of the patients [71 (63.3%)] had trans-vaginal route of balloon placement and 41 (36.7%) patients underwent trans-abdominal balloon placement. Most of the patients 69 (61.65%), responded to tamponing within 20 minutes of balloon placement while 9 patients had negative tamponade and continued to bleed. Bakri balloon tamponade was most commonly used in 84 (75.0%) patients. CG balloon and condom catheter were used only in 4 (3.6%) and 7 (6.3%) patients respectively. Tamponading was effective and successful in 103 (92%) patients.Conclusions: PPH is still a leading but preventable cause of maternal morbidity and mortality. In the majority of cases, relatively simple methods are used to avert a disaster, although these are not always employed. Uterine tamponade using intrauterine balloons appears to be an effective tool in the management of PPH.

Training of maternal health care providers in newer modalities of management of post-partum haemorrhage

Background: Postpartum haemorrhage (PPH) is a life-threatening complication, that occurs suddenly and unexpectedly. Institutional delivery by skilled birth attendant who are trained in active management of third stage of labour and those who can use of Uterine Balloon Tamponade and Non-pneumatic anti shock garment can reduce incidence and morbidity related to PPH. The objective of the paper was to share the experiences of the training programmes held for maternal health care workers in the newer modalities of PPH management.Methods: During one and a half year period, 32 Continuation of Medical Education (CME) programmes, with the theme of “Managing Obstetric Emergencies and Obstetric Trauma”, covering important topics related to high risk pregnancies like Hypertension, Eclampsia ,Anaemia and Haemorrhage at 32 health institutions, spread over 11 states and 2 union territories in India, were conducted .In addition,42 hands on workshops  at various health facilities were conducted with training of more than 2575 maternal health care providers.Results: The pre and post test scores revealed that 95 percent of the maternal health care providers were unaware about the use of Uterine Balloon Tamponade (Bakri balloon) in PPH and Non-pneumatic anti shock garment (NASG). Seventy percent were unaware about the proper sequence of steps of active management of third stage of labour. Training programmes helped to improve the knowledge, whereas hands on workshop, helped in skill development of the health care providers. The participants expressed great satisfaction regarding the knowledge and skills they acquired through training programme on management of post-partum haemorrhage. They gave positive feedback about the quality, contents and conduct of training programme.Conclusions: There is need for refresher training of maternal health care providers in newer modalities like AMTSL, NASG and Bakri balloon, which have potential to save lives.

Experiencia con el balón de Bakri en hemorragia obstétrica / Brakri balloon experience in obstetric hemorrhage

Resumen OBJETIVO: reportar la experiencia con el balón de Bakri en el control de la hemorragia obstétrica, su relación con la cantidad y concentraciones de hemoglobina antes y después de su aplicación. MATERIALES Y MÉTODOS: estudio prospectivo y observacional efec- tuado en dos unidades hospitalarias del 1 de enero al 31 de diciembre de 2016. A todas las pacientes se les aplicó el balón de Bakri por falta de respuesta a los uterotónicos. Variables de estudio: datos clínicos, cantidad de pérdida sanguínea antes y después de la aplicación del balón, cantidad de sangrado en el posparto y transcesárea, tiempo trascurrido entre el diagnóstico y la colocación, tiempo de llenado y volumen administrado, concentraciones de hemoglobina y pruebas de coagulación al ingreso a la unidad de atención, postsangrado y posterior a la aplicación, indicación de hemocomponentes, cantidad y tiempo de permanencia del balón, éxito y complicaciones. Se realizó análisis estadístico de todas estas variables. RESULTADOS: se incluyeron 20 pacientes con hemorragia posparto y transcesárea. La cantidad de sangrado después de la aplicación, tanto en los casos de posparto como transcesárea, fue menor y se obtuvo una adecuada respuesta. El tiempo medio entre el diagnóstico de la hemorragia y la colocación del balón fue de 30 minutos, tiempo medio de llenado de 5 minutos y cantidad media de llenado de 400 mL. El tiempo medio de permanencia del balón fue de 29.5 horas. En 95% de los casos se consiguió una respuesta favorable para el control de la hemorragia, sin complicaciones. CONCLUSIONES: la aplicación del balón de Bakri resultó en una medida útil, rápida y sin complicaciones para controlar la hemorragia obstétrica.

Abstract OBJECTIVE: To present the results obtained by using the Bakri Balloon to control obstetric hemorrhage. MATERIALS AND METHOD: Prospective, observational study within two inpatient medical care units from January 1 to December 31 2016. All of them were applied the Bakri Balloon because of failure to respond to uterotonic drug therapy. The following were analized: clinical data, amount of bleeding before and after the balloon, amount of postpartum or transcesarean bleeding, time between diagnosis and insertion, insufflation time and supplied volumen, hemoglobin levels and coagulation tests results initially, post-hemorrhage and post insertion, use of and amount of haemocomponents ministered, and the balloons use time, success, and complications. RESULTS: 20 patients with postpartum and transesarean hemorrhage are included. The amount of bleeding after insertion, both in postpartum and trans cesarean was reduced and there was an adequate response in hemoglobin levels. The average time between hemorrhage diagnosis and balloon insertion was thirty minutes; average insufflation time, five minutes, and average volumen supplied 400 mL. Balloon's average use time, 29.5 hours. In 95% of the cases there was a positive response for hemorrhage control, with no complications derived from use. CONCLUSIONS: The Bakri Balloon proved to be a useful, quick and complication-free therapy for controlling obstetric hemorrhage.

Efficacies of intrauterine balloon tamponade, intrauterine gauze tamponade and B-Lynch suture in prevention and treatment of postpartum hemorrhage / 第二军医大学学报

Objective To investigate the efficacies of intrauterine balloon tamponade, intrauterine gauze tamponade and B-Lynch suture in prevention and treatment of postpartum hemorrhage. Methods A total of 266 patients with high risk of postpartum hemorrhage or postpartum hemorrhage in our hospital from January 2013 to October 2014 were included in this study. They received intrauterine Bakri balloon tamponade (n=114), intrauterine gauze tamponade (n=69) or B-Lynch suture (n=83). The hemostatic effects of three methods and their relationship with different hemostasis occasions and high risk factors were analyzed. Results The hemostatic rates of intrauterine balloon tamponade, gauze tamponade and B-Lynch suture were 90.4%, 94.2% and 92.8%, respectively, with no significant differences found between the 3 groups (P>0.05). The hospitalization time, postpartum infection or involution of the uterus of three methods were not significantly different (P>0.05). The operation period was (46.08±13.8) min for intrauterine Bakri balloon tamponade, (56.49±12.94) min for intrauterine gauze tamponade, and (52.36±21.11) min for B-Lynch suture,with that of Bakri balloon group being significantly shorter than the other two groups (P<0.01). As for hemostatic occasion, 134 cases received preventive hemostatic treatment and were all successful, while 132 cases receiving hemostatic treatment had a successful rate of 84.1%, being significantly lower than that of the prevention hemostasis group (P<0.01); moreover, the postpartum infection rate was significantly lower in the prevention group compared with hemostatic treatment group (P<0.01). When placenta factor and uterine factor exist at the same time, the bleeding rate and bleeding volume of the mixed factor were significantly higher than that of single factor (P<0.01). Conclusion The three hemostasis methods have no differences in their hemostatic effects, hospitalization time, postpartum infection and uterine involution, with Bakri balloon's operation having the shortest time, therefore it may serve as an emergency hemostasis method to win more time for further treatment. The success rate of hemostasis depends not on the hemostasis method, but on the right occasions, the earlier the better. When placenta factor and uterine factor exist at the same time, the failure rate of hemostasis is higher, and emergency plans should be taken to reduce postpartum hemorrhage as soon as possible.

Uso del balón sos bakri en atonía uterina: serie de casos en un hospital universitario de tercer nivel / SOS bakri balloon use in uterine inertia. number of cases in a university tertiary hospital

Objetivo: Describir el uso del balón SOS Bakri en el tratamiento de la hemorragia posparto vaginal por atonía uterina después de la falla del tratamiento médico. Métodos: Se presenta una serie de 15 pacientes con hemorragia posparto vaginal por atonía uterina, tratadas satisfactoriamente con taponamiento uterino con balón SOS Bakri luego de no responder a tratamiento médico ni a masaje uterino. Resultados: La edad promedio de las pacientes fue 22,7 (± 6,8) años. La edad gestacional promedio fue 36,3 (± 2,6) semanas. El balón se insertó en los primeros 30 minutos del diagnóstico de la atonía uterina. El tiempo total que permaneció el balón en útero fue de 13,6 (± 6,1) horas. La pérdida hemática posterior a la colocación del balón fue en total 265,3 (± 258,1) cm3. El balón SOS Bakri fue efectivo en 100 % de las pacientes. Ninguna de las pacientes ameritó histerectomía. Conclusiones: El balón SOS Bakri es una alternativa eficaz mínimamente invasiva, económica y de fácil acceso en la terapéutica de la AU que no responde al tratamiento médico.

Objective: To describe the use of SOS Bakri Balloon in the treatment of postpartum hemorrhage after unsuccessful medical treatment of uterine atony. Method: We describe a case series of 15 patients with severe uterine atony after vaginal delivery that were successfully managed with SOS Bakri balloon after failed uterine massage and medical treatment. Results: The mean patient age was 22.7 (± 6.8) years. The mean gestational age was 36.3 (± 2.6) weeks. The balloon was inserted within 30 minutes of diagnosis of uterine atony. The mean length of balloon placement was 13.6 (± 6.1) hours. The mean total blood loss post balloon insertion was of 265.3 (± 258.1) cm3. The SOS Bakri balloon was effective 100 % of the time. None of the patient required hysterectomy. Conclusion: Insertion of SOS Bakri balloon is a simple conservative live saving alternative in the management of postpartum uterine atony.