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Hyperglycemia is a common complication of critical patients. Currently, clinical assessment of the changes in the blood glucose of critical patients is mainly based on the intermittent monitoring of peripheral blood glucose at a certain time point. This method cannot get the true blood glucose fluctuation, and it is more difficult to find asymptomatic hyperglycemia and hypoglycemia, so the guiding value of blood glucose control is limited. Arterial blood is the most accurate sample of blood glucose monitoring, so it is urgent to ensure the accuracy of arterial blood sample. A continuous arterial blood glucose monitoring equipment was independently developed by general surgical intensive care unit (ICU) of the First Affiliated Hospital of Nanjing Medical University, and National Utility Model Patent of China was obtained. It could greatly improve the efficiency of medical staff, and provide accurate and dynamic statistic data that would be an important basis for doctors' clinical decision-making. The continuous arterial blood glucose monitoring equipment was mainly composed of arterial pressure measuring monitor, program-controlled dynamic blood glucose meter, wire, electric switch, integrated collecting syringe, electric clip, rotary electric bracket, and blood glucose test strips, etc., which could be continuously and dynamically monitor patient blood glucose levels and perform various additional value-added functions such as automatic recording and alarming.
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Objective To evaluate the influence of hematocrit(HCT),vitamin C(Vc)and galactose on three portable blood glucose meters to provide some reference for clinical selection of appropriate blood glucose me-ter.Methods 20 heparin anticoagulant venous blood samples in the clinical laboratory department of Nanfang Hospital were selected for verifying the accuracy of blood glucose meter.2 healthy volunteers were selected for collecting 5 w hole blood samples in interferent test.Referring to the detection results of Roche automatic bio-chemical analyzer,the Nova StatStrip Xpress glucometer,Bayer Contour Plus glucometer and Roche Accu-chek Performa blood glucose meter were performed the accuracy verification.The influence of HCT,Vc and galac-tose on the detection results of above three portable blood glucose meters were evaluated.Results The detec-tion accuracy of Nova StatStrip Xpress and the Roche Accu-Chek glucometers all conformed to the require-ments of ISO15197:2013 standards.The detection accuracy of Bayer Contour Plus glucometer only conformed to the requirements of ISO15197:2003 standards.Under the interference of different levels of HCT,Vc and galactose,the detection results of Nova StatStrip Xpress glucometer conformed to the requirements of ISO15197:2013 standards;w hen detecting low concentration of blood glucose,the Bayer Contour Plus glucom-eter was interfered by 10 mg/dL Vc,and other detection results conformed to the requirements of ISO15197:2003 standards;the anti-interference performance of Roche Accu-chek Performa glucometer conformed to the
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Objectivde To explore the efficacy of i-GMS applied to the diabetes patient outside the hospital.Methods Totally 80 type 2 diabetes mellitus patients were divided into an experiment group (Group A) and a control group (Group B).Group A executed blood glucose monitoring by Glucose Management App and intelligent blood glucose meter (personal version),and Group B completed monitoring by some portable blood glucose meter.Telephone follow-up was performed once a week,and the two groups were compared on glycated albumin (GA) value 3 weeks after discharging,values of HbA1c,FPG and PG2h 3 months after,the times of blood glucose monitoring and hypoglycaemia as well as the patient satisfaction over the glucose management.Results Group A had the values of GA,HbA1c,FPG and PG2h significantly lower than those of Group B (P＜ 0.05).The times of glucose monitoring and patient satisfaction in Group A were statistically higher than those of Group B,while the incidence rate of hypoglycaemia of the former was lower than that of the latter (P＜0.05).Conclusion I-GMS proves efficient when used for glucose self monitoring and management of the type 2 diabetes mellitus patient.
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Objective To compare GM260 portable blood glucose meter and AU5821 automatic biochemical analyzer in order to prove the accuracy of GM260 and its applicability for clinical use.Methods Totally 20 pieces of EDTA-K2 anticoagulative specimens and 23 GM260 meters were numbered,and each specimen underwent examinations by both GM260 and AU5821,then the bias between the two kinds of devices was calculated.Results The maximal bias between GM260 and AU5821 was 0.47 mmol/L and all the meters had the bias between-0.83 and 0.83 mmol/L in case of 5 specimens with the glucose concentration less than 4.2 mmol/L;the maximal bias between GM260 and AU5821 was 18.07％ and all the meters had the bias between-20％ and 20％ in case of 15 specimens with the glucose concentration not less than 4.2 mmol/L;the examination results by GM260 all accorded with industrial standard.The results by GM260 were lower than those by AU5821,and the maximal negative deviation was-13.43％.Conclusion Portable blood glucose meter can only be used for screening,and automatic biochemical analyzer is the preferred device for diabetes diagnosis.
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Introducción: La hipoglicemia es común en el recién nacido (RN) pero si es persistente o muy profunda puede generar secuelas neurológicas. Los objetivos de esta investigación fueron describir los valores de glicemia capilar de los recién nacidos de riesgo y determinar los factores de riesgo de hipoglicemia de los neonatos de riesgo del Hospital Nacional (Itauguá, Paraguay). Materiales y Métodos: Se midió la glicemia capilar con glucómetro digital en los RN de riesgo Hospital Nacional (Itauguá, Paraguay) entre mayo 2015 y febrero 2016. Para determinar los factores de riesgo se aplicó luego un diseño de casos (RN con hipoglicemia) y controles (RN sin hipoglicemia). Las variables independientes fueron las patologías asociadas del RN, prematurez, restricción del crecimiento intrauterino, parto por cesárea, sexo del RN, hipertensión arterial y diabetes gestacional. Resultados: Se incluyeron 76 RN, 56,6% del sexo masculino, con edad gestacional media 36±3 semanas, con mediana de peso 2.569 g, nacidos por cesárea en 68,4%. Se encontraron 25 RN con hipoglicemia <47 mg/dL (casos) y 51 sin hipoglicemia (controles). Los factores de riesgo estadísticamente significativos asociados a la hipoglicemia neonatal fueron la prematurez y la presencia de patologías asociadas: dificultad respiratoria, sepsis y asfixia perinatal. Se halló considerable correlación entre glicemia capilar y glicemia plasmática (r +0,6). Conclusiones: Los factores de riesgo estadísticamente significativos asociados a la hipoglicemia neonatal fueron la presencia de patologías asociadas (dificultad respiratoria, sepsis y asfixia perinatal) y la prematurez. La correlación entre la glicemia capilar y la plasmática fue considerable (r+0,6).
Introduction: Hypoglycemia is common in the newborn (RN) but if it is persistent or too deep can cause neurological sequelae. The objectives of this study were to describe the values determined by capillary glycemia digital glucometer in the RN risk and analyze the risk factors associated with hypoglycemia. Materials and Methods: Capillary glucose was measured with digital glucometer in the risk RN National Hospital (Itauguá, Paraguay) between May 2015 and February 2016. To determine the risk factors design cases (RN with hypoglycemia) was then applied and controls (RN without hypoglycemia). The independent variables were associated pathologies RN, prematurity, intrauterine growth restriction, cesarean birth, sex RN, high blood pressure and gestational diabetes. Results: RN 76 were included, 56.6% male, mean age 36 ± 3 gestational weeks with median weight 2,569 g, born by Caesarean section at 68.4%. RN 25 were found with hypoglycemia <47 mg / dL (cases) and 51 without hypoglycemia (controls). Statistically significant risk factors associated with neonatal hypoglycemia were prematurity and the presence of associated diseases: respiratory distress, sepsis and perinatal asphyxia. It was found significant correlation between capillary glycemia and plasma glucose (r +0.6). Conclusions: Significant risk factors statistically associated with neonatal hypoglycemia were the presence of associated diseases (respiratory distress, sepsis and perinatal asphyxia) and prematurity. The correlation between capillary glucose and plasma was significant (r + 0.6).
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Objective:To study the influence of hematocrit on the consistency between blood glucose meters and automatic biochemical analyzer for testing blood glucose of peripheral blood and venous blood.Methods: 200 cases of diabetic and non-diabetic patients were selected in our hospital from January 2013 to September 2015, in which 124 cases were diabetics and 76 cases were non-diabetics. All the selected patients were treated with venous blood and peripheral blood glucose testing by the SIEMENS ADVIA1800 full automatic biochemical analyzer and three brand of blood glucose meters (Reiter GM300, Arkray GT-1920, Johnson & Johnson One Touch), comparing their consistency.Results: The hematocrit range was 35.1~51.6%, accounted for 91.0%(182), 25.0~35.0% of patients accounted for 9.0%(18), and average hematocrit was (42.3±4.2). When hematocrit was 35.1~51.6%, the correlation of automatic biochemical analyzer and Reiter GM300 blood glucose meter was high and stable, followed by Arkray GT-1920 and Johnson &Johnson One Touch. When hematocrit was 25.0~35.0%, the correlation of automatic biochemical analyzer and three blood glucose meters were high than hematocrit was 35.1~51.6%. There was no significant difference between SIEMENS ADVIA1800 automatic biochemical analyzer and Reiter GM300 about monitoring the blood glucose results, but there were significant differences between Johnson and Johnson One Touch and Arkray GT-1920.Conclusion: The automatic biochemical analyzer and three blood glucose meters have good correlation. When hematocrit is greater than 35%, the correlation is lower; when hematocrit is less than 35%, the correlation increases.
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Objective To investigate the impact of uric acid on peripheral blood glucose measured by the portable blood glu‐cose meter .Methods A total of 60 inpatients with 2 diabetic mellitus(T2DM ) complicating hyperuricemia were chosen as the re‐search group and contemporaneous 60 cases of T2DM without complicating hyperuricemia as the control group .Blood glucose in both groups was measured by the portable blood glucose meter ,meanwhile plasma glucose and serum uric acid were assessed by the biochemical analyzer in order to explore the impact of uric acid on peripheral blood glucose .Results (1)The difference between pe‐ripheral blood glucose and venous blood glucose was correlated with serum uric acid .(2)There was statistically significant differ‐ence in the blood glucose between the two groups .(3 ) The bias of blood glucose value were within the acceptable range . Conclusion Serum uric acid has certain influence on the peripheral blood glucose ,but which is within the acceptable range .The de‐tected blood glucose value of the portable blood glucose meter can be trusted .
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Objective:To design and construct a blood glucose meter quality control management information system. Methods:according to the existing portable blood glucose meter in use process problem, in the analysis of the current hospital existing blood glucose meter management mode and method of quality control, puts forward the design scheme of quality control management information system. Results:The function of the system includes blood glucose meter account information management, quality control records management, and biochemical comparison results management, management rules and related management system and instruments in the course of using the consumable management, to realize the dynamic management of the quality control of blood glucose meter. Conclusion:through the application of blood glucose meter quality control management system, achieved to ensure the clinical safety and effectiveness of the use of.
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Objective To evaluate the precision and accuracy of blood glucose meter(BGM ) for community home use testing . Methods According to the In Vitro Diagnostic Test Systems‐Requirements for Blood Glucose Monitoring Systems for Self‐Testing in Managing Diabetes Mellitus in DIN EN ISO15197 :2013 .Capillary blood and venous blood were tested by BGM and the laborato‐ry biochemical analyzer respectively .The measurement results of each BGM were compared with the results of the biochemical ana‐lyzer for conducting the bias analysis .Results In evaluated 20 BGM ,none of them met the requirements of ISO15197 :2013(when blood glucose concentrations < 5 .5 mmol/L ,the bias in 95% of detection results is within the range of ± 0 .83 mmol/L ;when blood glucose concentrations ≥ 5 .5 mmol/L ,the bias in 95% of detection results is within the range of ± 15% .Only 11 imported BGM (55% ) met the state standard .Conclusion The bias of 20 BGM ranged - 28 .7% - 3 .8% ,with the average bias of - 12 .2% . These detection results will bring the large risk of therapy in the diabetic patients .The regular and standardized evaluation of BGM performance may ensure the quality of blood glucose self - monitoring .
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Objective To explore the clinical application value of fast blood glucose meter in the emergency test of blood glu‐cose .Methods 186 critical patients in or hospital from August 2013 to August 2014 were selected for conducting the clinical re‐search .The average blood sugar was detected in all the research subjects by using the fast blood glucose meter and the fully auto‐matic biochemical analyzer .Results The consistency rate of detection results by the two kinds of detection method reached 22 .04% ,the difference of data was relatively small .In addition ,the detection time for the fast blood glucose meter was significantly shorter than that of the fully automatic biochemical analyzer ,the difference showed the statistical significance (P< 0 .05) .Conclu‐sion The detection results of the fast blood glucose meter have no too large difference with those of fully automatic biochemical an‐alyzer and have the same guidance significance to the diagnosis and treatment .The fast blood glucose meter has the advantages of quickness and convenience ,short time‐consuming and can be used in emergency .
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Objective: To apply the norms of the portable blood glucose meter in clinic and improve the quality and level of blood glucose detection. Methods:The management organization of the portable blood glucose meter was established. The organization understudied the working principles and the advantages and disadvantages of blood glucose meter. The model of the portable blood glucose meter was unified in a medical unit. The performance of the portable blood glucose meter and the biochemical analyzer was compared. The organization established standard operating procedures, strengthen personnel training. The clinical staff takes quality control regular. Results:The qualified rate of the use, the maintenance and the results detection was increased. Conclusion:The standardized management system guarantees the detection result of the portable blood glucose meter.
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Avaliou-se a precisão analítica e clínica de dois sensores portáteis para mensuração da glicemia em cães. Os valores da mensuração da glicemia obtidos com os sensores foram comparados com aqueles obtidos pelo método padrão da glicose oxidase, por meio da análise de correlação e da análise da grade de erros. Os resultados gerados pelos sensores não foram diferentes do método padrão. Conclui-se que ambos os sensores são adequados para mensuração da glicemia em cães
The clinical and analytical accuracy of two portable meters for glucose measurement in dogs was evaluated. Blood glucose values obtained by the use of portable meters were compared to those obtained using the glucose oxidase reference method, by means of correlation and error analysis. Results obtained with the blood glucose meters were not different from those obtained with the reference method. Both apparatus evaluated are adequate for use in dogs