Association Between Different Blood Pressure Levels at Baseline and Early-onset Heart Disease Among Young Population Under 40 Years Old / 中国循环杂志

Objectives:To explore the association between different blood pressure levels at baseline and early-onset heart disease among young adults under 40 years in China. Methods:This prospective cohort study included 35 993 subjects who participated in the physical examination of the employees of Kailuan Group for the first time from 2006 to 2012 and were younger than 40 years,with complete blood pressure data and had no history of heart disease.Participants were followed up to the end of 2021.The primary endpoint was early-onset heart disease(including coronary heart disease,atrial fibrillation,and heart failure).According to 2018 Chinese guidelines for the management of hypertension,the participants were divided into four groups:normal blood pressure group(n=13 208),elevated blood pressure group(n=16 576),stage 1 hypertension group(n=4 357),and stage 2-3 hypertension group(n=1 852).The cumulative incidence of heart disease among participants with different blood pressure levels at baseline was compared using log-rank test.Multivariate Cox proportional hazard regression model was used to analyze the impact of different blood pressure levels at baseline on early-onset heart disease in this cohort. Results:After a mean follow-up of(12.5±2.6)years,the cumulative incidence of early-onset heart disease in normal blood pressure group,elevated blood pressure group,stage 1 hypertension group,stage 2-3 hypertension group were 0.47%,0.97%,3.56%and 4.42%respectively(log-rank P<0.01).After adjusting for confounding factors such as age and sex,Cox regression analysis showed that the HR(95%CI)of heart disease in the elevated blood pressure group,hypertension grade 1 group and hypertension grade 2-3 group were 1.59(1.12-2.24),2.08(1.41-3.08)and 3.20(2.11-4.85)(all P<0.01),respectively,compared with the normal blood pressure group. Conclusions:Elevated blood pressure is a risk factor for early-onset heart disease among young Chinese population.

Study on relationship between prevalence or co-prevalence of risk factors for cardiovascular disease and blood pressure level in adults in China / 中华流行病学杂志

Objective: To study the relationship between blood pressure level and major risk factors for cardiovascular diseases in adults in China. Methods: A total of 179 347 adults aged ≥18 years were recruited from 298 surveillance points in 31 provinces in China in 2013 through complex multistage stratified sampling. The survey included face to face interview and physical examination to collect information about risk factors, such as smoking, drinking, diet pattern, physical activity, overweight or obesity, and the prevalence of hypertension. The blood pressure was classified into 6 levels (ideal blood pressure, normal blood pressure, normal high blood pressure and hypertension phase Ⅰ, Ⅱ and Ⅲ). The relationship between the prevalence or co-prevalence of risk factors for cardiovascular disease and blood pressure was analyzed. Results: The adults with ideal blood pressure, normal blood pressure, normal high pressure, hypertension phase Ⅰ, Ⅱ and Ⅲ accounted for 36.14%, 22.77%, 16.22%, 16.43%, 5.97% and 2.48%, respectively. Among them, the blood pressure was higher in men, people in Han ethnic group and those married, and the blood pressure was higher in those with older age, lower income level and lower education level, the differences were all significant (P<0.05). Whether taking antihypertensive drug or not, co-prevalence of risk factors influenced the blood pressure levels of both sexes (P<0.05), and the blood pressure levels of those taking no antihypertensive drug was influenced more by the co-prevalence of risk factors. Finally, multiple logistic analysis showed that the risks for high blood pressure in adults with 1, 2 and ≥3 risk factors were 1.36, 1.79 and 2.38 times higher, respectively, than that of the adults without risk factor. Conclusion: The more the risk factors for cardiovascular disease in adults, the higher their blood pressure were. It is necessary to conduct comprehensive behavior intervention targeting ≥ 2 risk factors for the better control of blood pressure in general population.

Study on relationship between prevalence or co-prevalence of risk factors for cardiovascular disease and blood pressure level in adults in China / 中华流行病学杂志

Objective To study the relationship between blood pressure level and major risk factors for cardiovascular diseases in adults in China.Methods A total of 179 347 adults aged ≥18 years were recruited from 298 surveillance points in 31 provinces in China in 2013 through complex multistage stratified sampling.The survey included face to face interview and physical examination to collect information about risk factors,such as smoking,drinking,diet pattern,physical activity,overweight or obesity,and the prevalence of hypertension.The blood pressure was classified into 6 levels (ideal blood pressure,normal blood pressure,normal high blood pressure and hypertension phase Ⅰ,Ⅱ and Ⅲ).The relationship between the prevalence or co-prevalence of risk factors for cardiovascular disease and blood pressure was analyzed.Results The adults with ideal blood pressure,normal blood pressure,normal high pressure,hypertension phase Ⅰ,Ⅱ and Ⅲ accounted for 36.14％,22.77％,16.22％,16.43％,5.97％ and 2.48％,respectively.Among them,the blood pressure was higher in men,people in Han ethnic group and those married,and the blood pressure was higher in those with older age,lower income level and lower education level,the differences were all significant (P＜0.05).Whether taking antihypertensive drug or not,co-prevalence of risk factors influenced the blood pressure levels of both sexes (P＜0.05),and the blood pressure levels of those taking no antihypertensive drug was influenced more by the co-prevalence of risk factors.Finally,multiple logistic analysis showed that the risks for high blood pressure in adults with 1,2 and ≥3 risk factors were 1.36,1.79 and 2.38 times higher,respectively,than that of the adults without risk factor.Conclusion The more the risk factors for cardiovascular disease in adults,the higher their blood pressure were.It is necessary to conduct comprehensive behavior intervention targeting ≥ 2 risk factors for the better control of blood pressure in general population.

Influence of nifedipine extended release tablets combined with indapamide tablets on blood pressure and renal function of patients with primary hy-pertension / 中国现代医生

Objective To analyze the influence of nifedipine extended release tablets combined with indapamide tablets on the blood pressure and renal function of patients with primary hypertension. Methods A total of 117 patients with primary hypertension were randomly divided into two groups. The control group was given nifedipine extended release tablets and the experimental group was given nifedipine extended release tablets combined with indapamide tablets. Three months later, the comprehensive efficacy, blood pressure changes, renal function indicators and adverse drug re-actions of the two groups were compared. Results The total effective rate of the experimental group was 91.53%, which was higher than the 75.86% of the control group, with statistically significant difference (P<0.05). The experimental group had lower influence on the blood pressure and renal function than the control group (P<0.01). The incidence of adverse reactions of the experimental group was 10.17%, The control group was 8.62%, there was not statisticatly sig-nificant.difference (P>0.05). Conclusion In the treatment of primary hypertension, nifedipine extended release tablets combined with indapamide tablets shows accurate efficacy in reducing and controlling blood pressure, can increase re-nal blood flow volume to reduce renal damage, and is safe and reliable.