Body adiposity markers and insulin resistance in patients with type 1 diabetes

ABSTRACT Objectives: Body composition changes are associated with adverse effects such as increased insulin resistance (IR) in individuals with diabetes mellitus. This study aims to evaluate the association between different body adiposity markers and IR in adults with type 1 diabetes (T1D). Subjects and methods: The cross-sectional study included outpatient adults with T1D from a university public hospital in southern Brazil. The body adiposity markers studied were waist circumference (WC), waist-height ratio (WHtR), body mass index (BMI), conicity index (CI), lipid accumulation product (LAP) and body adiposity index (BAI). IR was calculated using an Estimated Glucose Disposal Rate (EGDR) equation (analyzed in tertiles), considering an inverse relation between EGDR and IR. Poisson regression models were used to estimate the odds ratio (OR) and 95% CIs of association of adiposity markers with IR. Results: A total of 128 patients were enrolled (51% women), with a median EGDR of 7.2 (4.4-8.7) mg.kg−1.min−1. EGDR was negatively correlated with WC (r = −0.36, p < 0.01), WHtR (r = −0.39, p < 0.01), CI (r = −0.44, p < 0.01), LAP (r = −0.41, p < 0.01) and BMI (r = −0.24, p < 0.01). After regression analyses, WC (OR = 2.07; CIs: 1.12-3.337; p = 0.003), WHtR (OR = 2.77; CIs: 1.59-4.79; p < 0.001), CI (OR = 2.59; CIs: 1.43-4.66; p = 0.002), LAP (OR = 2.27; CIs: 1.25-4.11; p = 0.007) and BMI (OR = 1.78; CIs: 1.09-2.91; p = 0.019) remained associated with IR. Conclusions: The authors suggest using the studied adiposity markers as a routine since they were shown to be suitable parameters in association with IR.

Dietary amino acids and anthropometric indices: Tehran Lipid and Glucose Study

ABSTRACT Objective: Recent studies investigated the role of amino acids (AAs) in weight management. We aimed to determine the association between AAs and three-year change of anthropometric indices and incident obesity. Materials and methods: Height, weight, hip, and waist circumference (WC) were collected at baseline and follow up. Three-year changes in anthropometric indices and obesity incident according to body mass index (BMI) (overweight & obesity) and WC cutoffs (obesity-WC) were ascertained. Dietary intakes of AAs were collected at baseline, using a food frequency questionnaire. Data analyses were conducted on 4976 adult participants and two subsamples, including 1,570 and 2,918 subjects, for assessing the AAs relationship with 3-year changes on anthropometric indices and obesity incident. Results: Lysine and aspartic acid were positively associated with higher weight change, whereas acidic AAs, cysteine, and glutamic acid showed a negative correlation with weight change. Furthermore, a weak positive correlation was shown for alkaline AAs, lysine, and valine with WC; however, acidic AAs, tryptophan, cysteine, and glutamic acid were negatively associated with WC. Aromatic and acidic AAs also demonstrated a weak negative relation with changes in BAI. Phenylalanine and Aromatic AAs showed a negative association with overweight &obesity incidence adjusting for potential confounders. Each quartile increases the dietary lysine, arginine, alanine, methionine, aspartic acid, and alkaline AAs related to a greater risk of obesity-WC, while tryptophan, glutamic acid, proline, and acidic AAs associated with lower obesity-WC risk. Conclusion: Our results suggested that certain dietary AAs may potentially change anthropometric indices and risk of obesity incident.

Excess adiposity and low physical fitness hamper Supine-to-Stand test performance among sedentary adolescents

Abstract Objective: The aim of this study was to analyze the relationship between body adiposity and physical fitness with performance in the Supine-to-Stand test (STS-test) in sedentary adolescents. Methods: Sixty-two adolescents, of both sexes, between 10 and 16 years old, participated in the study. Body mass (BM), height, waist circumference (WC), fat mass (FM), fat-free mass (FFM), right and left handgrip strength (HGS-right, HGS-left), abdominal resistance (ABDO), flexibility (FLEX), and cardiorespiratory fitness (VO2peak) were measured. Body mass index (BMI), z-score BMI (BMI-z), tri-ponderal mass index (TMI) and waist-to-height ratio (WHtR) were calculated. The STS-test was applied to evaluate the STS-MC by the movement patterns in the execution of the test. The STS-time in seconds (s) was categorized into terciles: fast (FG < 2.0 s), intermediate (IG = 2.0-2.6 s) and slow (SG > 2.6 s). One-way ANOVA, Chi-square, Spearman's correlation coefficient as well as non-parametric tests were used, with significance p 0.05. Results: The SG presented higher BMI, BMI-z, TMI, WHtR, FM, %FM, as well as lower averages for %FFM, HGS-right, HGS-left, FLEX, ABDO, VO2peak, VO2peak relative to BM (VO2peakBM) in relation to GF. The BMI, BMI-z, TMI, WC, WHtR and FM showed moderate and direct correlations with STS-time and inverse with STS-MC (p < 0.01). HGS-right, HGS-left, ABDO, and VO2peakBM showed moderate and an inverse correlation with STS-time (p < 0.05). The VO2peakBM was moderate and with direct correlations to STS-MC (p < 0.01). Conclusion: It is concluded that excess fat and low physical fitness hamper STS-test performance. Therefore, the STS-test can be used for screening students to assess MC.

Relación entre adiposidad corporal y presión arterial en niños y adolescentes con enfermedades reumáticas / Relationship between body adiposity and blood pressure in children and adolescents with rheumatic diseases

Introducción: las enfermedades reumáticas son un grupo de afecciones que se caracterizan por la presencia, generalmente, de dolor, inflamación, deformidad, discapacidad funcional y disminución de la percepción de calidad de vida relacionada con la salud. Las complicaciones cardiovasculares son frecuentes en el curso de estas enfermedades; los trastornos nutricionales pueden ser causa o consecuencia de estas complicaciones. Objetivo: determinar la relación existente entre adiposidad corporal y presión arterial en niños y adolescentes con enfermedades reumáticas. Metodos: estudio descriptivo, de corte transversal en 45 pacientes con enfermedades reumáticas diagnosticadas según los criterios del American College of Reumathology. Se utilizó la técnica de bioimpedancia para determinar el porcentaje de grasa corporal e índice de correlación de Pearson para determinar relación entre variable. Resultados: promedio de edad de 12,26 ± 8,74 años, predominio de pacientes femeninas (68,69 por ciento) y entre 15 y 18 años de edad (42,22 por ciento). La enfermedad reumática más representada fue la artritis idiopática juvenil (46,67 por ciento). Predominaron los pacientes con aumento del porcentaje de grasa, donde el sobrepeso (44,44 por ciento) y la obesidad (20,0 por ciento) fueron los más representados. El 20,0 por ciento de los pacientes incluidos en la investigación presentaron alteraciones de la presión arterial con predominio en pacientes obesos (33,33 por ciento) y con sobrepeso (20,0 por ciento). Conclusiones: Mantener un adecuado control de la adiposidad corporal disminuye considerablemente la posibilidad de aparición de trastornos de la presión arterial. La bioimpedancia eléctrica es un método de fácil aplicación y de comprobada efectividad para determinar el porcentaje de grasa(AU)

Introduction: rheumatic diseases are a group of conditions that are characterized by the presence, usually, of pain, inflammation, deformity, functional disability and decreased perception of quality of life related to health. Cardiovascular complications are frequent in the course of these diseases; Nutritional disorders may be the cause or consequence of these complications. Objective: to determine the relationship between body adiposity and blood pressure in children and adolescents with rheumatic diseases. Methodology: descriptive, cross-sectional study in 45 patients with rheumatic diseases diagnosed according to the criteria of the American College of Reumathology. The bioimpedance technique was used to determine the percentage of body fat and Pearson's correlation index to determine the relationship between variables. Results: average age of 12.26 ± 8.74 years, predominance of female patients (68.69 percent) and between 15 and 18 years of age (42.22 percent). The most represented rheumatic disease was juvenile idiopathic arthritis (46.67 percent). Patients with increased fat percentage predominated, where overweight (44.44 percent) and obesity (20.0 percent) were the most represented. 20.0 percent of the patients included in the investigation presented alterations in blood pressure, predominantly in obese patients (33.33 percent) and overweight (20.0 percent). Conclusions: Maintaining adequate control of body adiposity considerably reduces the possibility of the appearance of blood pressure disorders. The electric bioimpedance is a method of easy application and proven effectiveness to determine the percentage of fat(AU)

Value of body adiposity index in the prediction of metabolic disease / 中国综合临床

Objective To discuss the value of body adiposity index( BAI) in the prediction of the risk of dysglycemia,dyslipidemia and hyperuricemia.Methods Five thousand and thirty residents as the participants from Jinshan New Area and nearby of Jinshan,Shanghai were enrolled,including 2004 males and 3026 females. The receiver operating characteristic curve( ROC) was drew to predict dysglycemia,dyslipidemia and hyperurice?mia by body mass index( BMI) ,waist circumference( WC) ,waist?hip ratio( WHR) and BAI in different gender groups.Medcale soft was used to compare the area under the curve.Results According to the ROC analysis,in males the area under curve in the prediction of dysglycemia of BMI,WC,WHR and BAI was 0.553,0.556,0. 538,0.540(P<0.05),and 0.513,0.523,0.523,0.535 in females(P<0.05).The area under curve in the predic?tion of dyslipidemia of BMI,WC,WHR and BAI was 0.641,0.626,0.563,0.588(P<0.05) in males and 0.617, 0.613,0.597,0.587(P<0.05) in females.The area under curve in the prediction of hyperuricemia of BMI,WC, WHR and BAI was 0.685,0.665,0.609,0.577(P<0.05) in males and 0.730,0.708,0.656,0.649(P<0.05) in females,and BMI, WC of AUC were higher than BAI both in males and females(P<0.05).Conclusion BAI could be a predictor for the risk of metabolic disease,but less than BMI and WC.

Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats

Ginkgo biloba extract (GbE) has been indicated as an efficient medicine for the treatment of diabetes mellitus type 2. It remains unclear if its effects are due to an improvement of the insulin signaling cascade, especially in obese subjects. The aim of the present study was to evaluate the effect of GbE on insulin tolerance, food intake, body adiposity, lipid profile, fasting insulin, and muscle levels of insulin receptor substrate 1 (IRS-1), protein tyrosine phosphatase 1B (PTP-1B), and protein kinase B (Akt), as well as Akt phosphorylation, in diet-induced obese rats. Rats were fed with a high-fat diet (HFD) or a normal fat diet (NFD) for 8 weeks. After that, the HFD group was divided into two groups: rats gavaged with a saline vehicle (HFD+V), and rats gavaged with 500 mg/kg of GbE diluted in the saline vehicle (HFD+Gb). NFD rats were gavaged with the saline vehicle only. At the end of the treatment, the rats were anesthetized, insulin was injected into the portal vein, and after 90s, the gastrocnemius muscle was removed. The quantification of IRS-1, Akt, and Akt phosphorylation was performed using Western blotting. Serum levels of fasting insulin and glucose, triacylglycerols and total cholesterol, and LDL and HDL fractions were measured. An insulin tolerance test was also performed. Ingestion of a hyperlipidic diet promoted loss of insulin sensitivity and also resulted in a significant increase in body adiposity, plasma triacylglycerol, and glucose levels. In addition, GbE treatment significantly reduced food intake and body adiposity while it protected against hyperglycemia and dyslipidemia in diet-induced obesity rats. It also enhanced insulin sensitivity in comparison to HFD+V rats, while it restored insulin-induced Akt phosphorylation, increased IRS-1, and reduced PTP-1B levels in gastrocnemius muscle. The present findings suggest that G. biloba might be efficient in preventing and treating obesity-induced insulin signaling impairment.

Comparison of the functional profile of elderly women with urinary continence and incontinence / Comparação do perfil funcional de mulheres idosas com continentes urinária e incontinentes urinária

Urinary incontinence (UI), more prevalent in women and influencing their functional decline, increases with age. Current longitudinal study with two data collection in 2005-2006 and 2011 compares the functional profile of urinary continence and incontinence in elderly women. Sixty-eight women were divided into females with urinary continence (CG; n = 62) and females with urinary incontinence (IG; n = 6). Dependent variables measured were obesity and body adiposity indexes and functional fitness. Data were given in means with standard deviation (±) and analyzed by the independent t-test (p < 0.05). There were six cases of UI. In the first evaluation group differences occurred for waist circumference (CG: 85.3±9.7 cm; IG: 91.2 ± 12.4cm; t=-2.267; p < 0.05) and cardiorespiratory fitness (CG: 517.9 ± 67.3 m; IG: 463.0±85.9 m; t = 2.571; p < 0.05). CG had a better functional profile, excepting flexibility and lower limbs strength, in the second evaluation. Women with UI had higher waist circumference and lower cardiorespiratory fitness. This may be due to the relationship between the variables and greater abdominal compression and functional decline. Results show that future public health strategies should focus on these factors to decrease the risk of people developing UI and to improve physical-functional and psycho-social benefits to elderly women.

O risco de incontinência urinária (IU) aumenta com o decorrer da idade, sendo mais prevalente em mulheres e pode acelerar o declínio funcional. O objetivo do estudo foi comparar a aptidão funcional de idosas continentes e incontinentes. Estudo longitudinal com duas avaliações: 2005-2006 e 2011. Participaram deste estudo 68 mulheres classificadas em: continentes (GC; n = 62) e Incontinentes (GI; n = 6) . Foram avaliados indicadores de obesidade e adiposidade corporal, e aptidão funcional. Os dados foram descritos pela média, desvio-padrão (±) e analisados pelo Test-t independente. Ocorreram seis casos incidentes de IU. Os grupos diferiram nas variáveis circunferência de cintura (GC: 85,3 ± 9,7 cm; e GI: 91,2 ± 12,4 cm; t = -2,267; p < 0,05) e aptidão cardiorrespiratória (GC: 517,9 ± 67,3 m; e GI: 463,0 ± 85,9 m; t = 2,571; p < 0,05) na primeira avaliação. O GC apresentou melhor perfil funcional, com exceção da flexibilidade e força de membros inferiores na segunda avaliação. Mulheres que desenvolveram IU apresentam excesso de adiposidade central e menor aptidão cardiorrespiratória. Tal fato pode ser explicado pela relação dessas variáveis com maior compressão abdominal e o declínio funcional. Sendo assim, recomenda-se que futuras estratégias de saúde pública enfoquem esses fatores a fim de minimizar o risco de IU, e consequentemente, refletindo em benefícios físico-funcionais, e psicossociais a estes indivíduos.

Microbiota intestinal e risco cardiometabólico: mecanismos e modulação dietética / Intestinal microbiota and cardiometabolic risk: mechanisms and diet modulation

A microbiota intestinal, adquirida no período pós-natal, é composta por grande diversidade de bactérias que desempenham diferentes funções no hospedeiro humano, entre elas a absorção de nutrientes, proteção contra patógenos e modulação do sistema imune. O conteúdo bacteriano intestinal ainda não é totalmente conhecido, mas sabe-se que é influenciado por fatores internos e principalmente externos que modulam sua composição e função. Estudos indicam que a microbiota intestinal difere em indivíduos magros e obesos e ainda naqueles que mantêm hábitos alimentares diferentes. Há evidências de que as relações entre dieta, inflamação, resistência à insulina e risco cardiometabólico são em parte mediadas pela composição de bactérias intestinais. Conhecimentos sobre a microbiota poderão reverter em diferentes estratégias para manipular as populações bacterianas e promover saúde. Esta revisão aborda a relevância do conhecimento sobre o papel de fatores ou padrões alimentares na composição da microbiota, assim como mecanismos fisiopatológicos de doenças metabólicas crônicas e as potencialidades de prebióticos e probióticos sobre o perfil de risco cardiometabólico.

The gut microbiota obtained after birth is composed of a large range of bacteria that play different roles in the human host, such as nutrient uptake, protection against pathogens and immune modulation. The intestinal bacterial content is not completely known, but it is influenced by internal, and mainly by external factors, which modulate its composition and function. Studies indicate that the gut microbiota differs in lean and obese individuals, and in individuals with different food habits. There is evidence that the relationship between diet, inflammation, insulin resistance, and cardiometabolic risk are, in part, mediated by the composition of intestinal bacteria. Knowledge about the gut microbiota may result in different strategies to manipulate bacterial populations and promote health. This review discusses the relevance of understanding the role of dietary factors or patterns in the composition of the microbiota, as well as pathophysiological mechanisms of chronic metabolic diseases, and the potential of prebiotics and probiotics on the cardiometabolic risk profile.

Comparison of the Body Adiposity Index to Body Mass Index in Korean Women

PURPOSE: Obesity is a major public health issue and is associated with many metabolic abnormalities. Consequently, the assessment of obesity is very important. A new measurement, the body adiposity index (BAI), has recently been proposed to provide valid estimates of body fat percentages. The objective of this study was to compare the BAI and body mass index (BMI) as measurements of body adiposity and metabolic risk. MATERIALS AND METHODS: This was a cross-sectional analysis performed on Korean women. The weight, height, and hip circumferences of 2950 women (mean age 25+/-5 years old, 18-39 years) were measured, and their BMI and BAI [hip circumference (cm)/height (m)(1.5)-18] values were calculated. Bioelectric impedance analysis was used to evaluate body fat content. Glucose tolerance status was assessed with a 75-g oral glucose tolerance test, and insulin sensitivity was estimated with the insulin sensitivity index. RESULTS: BMI was more significantly correlated with fat mass and fat percentage. Additionally, BMI was also more significantly associated with metabolic parameters, including fasting glucose, post-load 2-h glucose, fasting insulin, post-load 2-h insulin, triglycerides, and high density lipoprotein cholesterol than BAI. Receiver operating characteristic curve analysis revealed that BMI was a better tool for predicting body fat percentage than BAI. Insulin sensitivity and metabolic syndrome were more significantly associated with BMI than with BAI. CONCLUSION: In Korean women, the current BMI-based classifications for obesity might be superior to BAI-based measurements for determining obesity and predicting metabolic risk.

Comparação da força muscular entre mulheres de meia idade com e sem sobrepeso/obesidade / Comparison of muscle strenght between middle-aged women with and without overweight/obesity

A obesidade é atualmente um dos maiores problemas de saúde pública em países desenvolvidos e em desenvolvimento. Apesar de a redução da força muscular estar fortemente associada à doenças cardiovasculares, poucos estudos analisaram a força muscular relativa em mulheres com e sem sobrepeso e obesidade. O presente estudo teve como objetivo comparar a força muscular absoluta e relativa de mulheres de meia idade com e sem sobrepeso e obesidade, além de correlacionar a força muscular relativa com o índice de massa corporal (IMC), com a circunferência da cintura (CC) e com a razão cintura-estatura (RCE). A hipótese inicial era de que mulheres com sobrepeso e obesidade apresentariam menores valores de força muscular relativa. Foram avaliadas 20 mulheres obesas (36,7 ± 7,9 anos; 33,4 ± 2,4 kg/m2), 46 sobrepesadas (34,8 ± 7,8 anos; 27,7 ± 1,2 kg/m2) e 53 eutróficas (33,2 ± 9,3anos; 22,3 ± 1,7 kg/m2). A classificação de sobrepeso (IMC > 25 < 29,9 kg/m2) e obesidade (IMC > 30 kg/m2) foi definida de acordo com a Organização Mundial de Saúde. A força muscular relativa [força absoluta (kg)/massa corporal (kg)] foi mensurada por meio do teste de preensão manual. A força muscular relativa foi respectivamente menor nas mulheres com obesidade e sobrepeso quando comparado as mulheres eutróficas (0,35 ± 0,05 vs 0,42 ± 0,06 vs 0,48 ± 0,08; P=0,001). Houve uma relação negativa do IMC (r=-0,60; P=0,001), CC (r=-0,45; P=0,001) e RCE (r=-0,41; P=0,001) com a forca muscular relativa. A redução da força muscular relativa é um aspecto característico de mulheres com sobrepeso e obesidade.

Obesity is currently one of the major public health problems in developed and developing countries. Although the decrease in muscle strength is highly associated with cardiovascular diseases, few studies analyzed the relative muscle strength in women with and without overweight and obesity. The present study aimed to compare absolute and relative muscle strength of middle-aged women with and without overweight and obesity, as well as, to correlate relative muscle strength with body mass index (BMI), waits circumference (WC) and waist-to-height ratio (WHR). The initial hypothesis was that overweight and obese women would present lower values of relative muscle strength. Twenty obese (36.7 ± 7.9 years; 33.4 ± 2.4 kg/m2), 46 overweight (34.8 ± 7.8 years; 27.7 ± 1.2 kg/m2) and 53 eutrophic women (33.2 ± 9.3 years; 22.3 ± 1.7 kg/m2) were evaluated. The cut-off point for overweight (IMC > 25 < 29.9 kg/m2) and obesity (IMC > 30 kg/m2) was defined according to the World Health Organization. Relative muscle strength [absolute strength (kg)/body mass (kg)] was measured by the handgrip test. Relative muscle strength was lower for women with obesity and overweight as compared with eutrophic women (0.35 ± 0.05 vs 0.42 ± 0.06 vs 0.48 ± 0.08; P=0.001), respectively. There was a negative correlation of BMI (r=-0.60; P=0.001), WC (r=-0.45; P=0.001) and RCE (r=-0.41; P=0.001) with relative muscle strength. The reduction of relative muscle strength is a characteristic aspect of women with overweight and obesity.

Índice de adiposidade corporal modificado para determinação de gordura corporal de adultos com obesidade mórbida / Modified Body Adiposity Index to determine body fat in morbid obese adults

INTRODUÇÃO: A obesidade mórbida tornou-se um importante problema de saúde pública. A medida de massa corporal não é capaz de identificar deficiências ou excessos dos diferentes componentes corporais, surgindo a necessidade de se avaliar a composição corporal. Não há consenso sobre o melhor método para esse fim em obesos mórbidos. O Índice de Adiposidade Corporal (IAC) foi proposto para ser um método simples e preciso para uma população de diversificada quantidade de gordura corporal (GC). OBJETIVO: Avaliar a eficácia do IAC em determinar GC de adultos com obesidade mórbida. MÉTODOS: O IAC foi comparado à Bioimpedância (BIA) em 240 adultos obesos mórbidos (Grupo 1= G1), uma equação específica para determinar GC em obesidade mórbida foi desenvolvida e, posteriormente, validada em outra amostra de 158 indivíduos (Grupo 2 = G2). RESULTADOS: Observou-se diferença significativa entre os dois métodos (p=0,039). A quantidade média de GC no G1 foi 52,3±6,1% segundo a BIA e 51,6±8,1% segundo o IAC, com uma diferença de 0,6±5,1% entre os métodos. Algumas variáveis, como gênero, RCQ e gravidade da obesidade confundiram o IAC. Para minimizar esses erros uma equação (Índice de Adiposidade Corporal Modificado = IACM) foi desenvolvida por meio de regressão linear (IACM% = 23,6 + 0,5 x (IAC); somar 2,2 se IMC >= 50kg/m2 e 2,4 se RCQ >= 1,05). A equação foi aplicada no G2 e possibilitou a redução da diferença entre os métodos (1,2±5,9% para 0,4±4,0%) e o fortalecimento da correlação entre eles (0,6 para 0,7). CONCLUSÕES: O IAC apresenta limitações para determinar porcentagem de gordura corporal de obesos mórbidos, já a equação sugerida (IACM) foi eficaz, não se apresentando significativamente diferente da Bioimpedância e corrigindo as limitações anteriormente apresentadas pelo IAC.

BACKGROUND: Morbid obesity has become a public health problem. As body mass is not able to identify deficiencies or excesses of body components, the need to assess body composition emerged. There is no consensus of the best method to measure body composition in morbidly obese adults and a simple, accurate, reproducible and inexpensive method is desirable. The Body Adiposity Index (BAI) has been proposed to be a simple and accurate method for a population with a diverse amount of body fat (BF). OBJECTIVE: Evaluate the efficacy of BAI in determining BF of morbid obese adults. METHODS: BAI was compared to bioimpedance (BIA) in 240 morbidly obese adults (Group One= G1) and a specific equation for morbid obesity has been developed to determine BF and then validated on another sample of 158 subjects (Group Two= G2). RESULTS: There was a significant difference between the two methods (p=0,039). The average amount of BF in G1 was 52.3±6.1%, according to BIA and 51.6±8.1% according to BAI, with a difference of 0.6±5.1% between methods. Some variables, such as gender, WHR and severity of obesity mistook BAI. To minimize these errors an equation (Modified Body Adiposity Index = MBAI) was developed by linear regression (MBAI% = 23.6 + 0.5 x (BAI); add 2.2 if BMI >= 50kg/m2 and 2.4 if WHR >= 1.05). The equation was applied to G2 and resulted in a reduction in the difference between methods (1.2±5.9% to 0.4±4.12%) and strengthening of the correlation between them (0.6 to 0.7). CONCLUSIONS: BAI has limitations in determine BF in morbid obesity. The suggested equation (MBAI) was effective for predicting body fat in morbid obese adults; MBAI wasn't significant different from BIA and was able to correct BAI limitations.

Adiposidade corporal, mas não resistência insulínica, associa-se ao polimorfismo -675 4G/5G no gene PAI-1 em uma amostra de crianças mexicanas / Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children

OBJETIVO: Elaboramos este estudo para avaliar se o polimorfismo -675 4G/5G no gene inibidor 1 do ativador do plasminogênio se associa à obesidade e à resistência insulínica em crianças mexicanas. MÉTODOS: Foi realizado um estudo transversal em 174 crianças, 89 delas com peso normal e 85 obesas, variando sua idade de 6 a 13 anos. Todas as crianças eram do estado de Guerrero e foram recrutadas de três escolas primárias na cidade de Chilpancingo, México. Os níveis de insulina foram determinados por prova imunoenzimática. Foi usado o modelo de avaliação da homeostase para determinar resistência insulínica. O polimorfismo -675 4G/5G no gene PAI-1 foi analisado pelo método reação de polimerase em cadeia-polimorfismo no comprimento dos fragmentos de restrição. RESULTADOS: A prevalência de resistência insulínica no grupo obeso foi mais alta (49,41%) do que no grupo com peso normal (16,85%). O polimorfismo 4G/5G do PAI-1 foi encontrado em equilíbrio de Hardy Weinberg. O genótipo 4G/5G contribuiu para um aumento significativo da relação cintura-quadril (β = 0,02, p = 0,006), da circunferência da cintura (β = 4,42, p = 0,009) e da espessura da prega subescapular (β = 1,79, p = 0,04), mas não se relacionou com a resistência insulínica. CONCLUSÃO: O genótipo -675 4G/5G do gene PAI-1 se associou a aumento da adiposidade corporal em crianças mexicanas.

OBJECTIVE: To assess whether the -675 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is associated with obesity and insulin resistance in Mexican children. METHODS: A cross-sectional study was performed in 174 children, 89 with normal-weight and 85 with obesity, aged from 6 to 13 years. All children were from state of Guerrero, and recruited from three primary schools in the city of Chilpancingo, Mexico. Insulin levels were determined by immunoenzymatic assay. The homeostasis model assessment was used to determine insulin resistance. The -675 4G/5G polymorphism in PAI-1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The prevalence of insulin resistance in the obese group was higher (49.41%) than in the normal-weight group (16.85%). The 4G/5G PAI-1 polymorphism was found in Hardy Weinberg equilibrium. The 4G/5G genotype contributed to a significant increase in waist-hip ratio (β = 0.02, p = 0.006), waist circumference (β = 4.42, p = 0.009), and subscapular skinfold thickness (β = 1.79, p = 0.04); however, it was not related with insulin resistance. CONCLUSION: The -675 4G/5G genotype of PAI-1 gene was associated with increase of body adiposity in Mexican children.

Reflexão sobre a imigração japonesa no Brasil sob o ângulo da adiposidade corporal / Reflection about Japanese immigration to Brazil under the light of body adiposity

Populações migrantes representam oportunidade para se investigar a contribuição de fatores ambientais na gênese da obesidade e suas comorbidades. Em 1993, o Japanese-Brazilian Diabetes Study Group estudou a prevalência de diabetes e doenças associadas em nipo-brasileiros residentes em Bauru, SP. Utilizando critérios específicos para asiáticos, 22,4 por cento dos nipo-brasileiros foram caracterizados como portadores de excesso de peso nessa primeira fase do estudo. Na segunda fase, em 2000, essa prevalência subiu para 44,2 por cento, e 50,3 por cento apresentavam obesidade central. Essa população também apresentava alta prevalência de diabetes tipo 2, hipertensão e dislipidemia, componentes da síndrome metabólica. O JBDS Group também mostrou a associação entre hábitos ocidentais, especialmente alimentação rica em gordura saturada, e a ocorrência de síndrome metabólica. Em 2005, motivado por esses achados, o JBDS Group iniciou a terceira fase do estudo que constou de programa de intervenção com base em orientação para dieta saudável e prática de atividade física, utilizando recursos factíveis em termos de saúde pública no Brasil. Após um ano de intervenção, o JBDS Group observou diminuição nos parâmetros antropométricos, pressão arterial e níveis de glicemia e colesterol. Tempo de acompanhamento maior é necessário para avaliar a persistência desses benefícios e o impacto deles no risco de desenvolver diabetes e eventos cardiovasculares.

Migrant populations represent a good opportunity to investigate the role of environmental factors for the genesis of obesity and its comorbidities. The Japanese-Brazilian Diabetes Study Group studied the prevalence of diabetes and related disorders in Japanese-Brazilians from Bauru, SP, in 1993. Using specific criteria for Asian, 22.4 percent of the Japanese-Brazilians were found as having overweight in this first phase of the study. In the second phase, in 2000, this prevalence increased to 44.2 percent and 50.3 percent had central obesity. This population also had high prevalence of type 2 diabetes, hypertension and dyslipidemia, components of the metabolic syndrome. The JBDS Group also showed the association between Occidentalized habits, mainly a rich saturated-fat-diet, and the occurrence of the metabolic syndrome. In 2005, motivated by these findings, the JBDS Group started the third phase of the study which was an intervention program based on healthy diet and physical activity recommendations, using resources that could be feasible in terms of public health in Brazil. After one year-intervention program, the JBDS Group observed a decrease in anthropometric parameters, blood pressure and plasma glucose and cholesterol levels. It will be necessary a longer follow-up to evaluate the maintainance of these benefits and their impact in the risk development of diabetes and cardiovascular events.

Aptidão física relacionada à saúde em escolares de Jequié, BA, Brasil / Health-related physical fitness in students from Jequié, BA, Brazil

O objetivo deste estudo foi analisar a aptidão física relacionada à saúde (AFRS) em escolares de Jequié, BA, Brasil. Para tanto, a AFRS de 182 meninos e 160 meninas (sete a 12 anos), escolares da rede pública de ensino, foi avaliada mediante a aplicação dos testes motores corrida/caminhada de nove minutos (indicador de resistência cardiorrespiratória), abdominal modificado em um minuto (indicador de força e resistência abdominal), sentar-e-alcançar (indicador de flexibilidade). O somatório das espessuras das dobras cutâneas tricipital e subescapular foi utilizado como indicador de gordura corporal. Os resultados encontrados indicaram maior prevalência de meninos e meninas abaixo (19 por cento e 49 por cento, respectivamente) do que acima (3 por cento e 1 por cento, respectivamente) dos critérios estabelecidos pela AAHPERD (1988) para indicadores de gordura corporal. Por outro lado, somente 51 por cento dos meninos e 58 por cento das meninas no sentar-e-alcançar; 11 por cento e 7 por cento, respectivamente, no abdominal modificado em um minuto, e 15 por cento e 14 por cento, respectivamente, na corrida/caminhada de nove minutos alcançaram os critérios estabelecidos. Portanto, os resultados sugerem que programas efetivos de intervenção parecem necessários para a promoção de mudanças no estado nutricional e na atividade física habitual de escolares de Jequié.

The aim of this study was to analyze the health-related physical fitness (HRPF) in students from Jequié, BA, Brazil. Therefore, the HRPF of 182 boys and 160 girls aged 7-12 years, students from public schools, was assessed by the application of 9-minute-run/walk (indicator of cardiorespiratory capacity), modified in one minute abdominal (indicator of abdominal strength and endurance), sit-and-reach (indicator of flexibility) motor tests. The sum of the triciptal and subscapular skinfolds thickness was used as indicator of body fat. The results found indicated higher prevalence of boys and girls below (19 percent and 49 percent, respectively) than above (3 percent and 1 percent, respectively) the criteria established by the AAHPERD (1988) for indicators of body fat. Conversely, only 51 percent of the boys and 58 percent of the girls in the sit-and-reach; 11 percent and 7 percent, respectively, in the modified in one minute abdominal; and 15 percent and 14 percent, respectively, in the 9-minute-run/walk reached the established criteria. Thus, the results suggest that effective intervention programs seem necessary for the promotion of alterations in the nutritional status as well as habitual physical activity of students from Jequié.

Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables

During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17 percent protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6 percent). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.

Diagnóstico da aptidão física em escolares de alto nível socioeconômico: avaliação referenciada por critérios de saúde / Physical fitness diagnosis in schoolchildren of high socioeconomic status: evaluation for health criterion reference

A prática regular de atividades físicas sistematizadas na infância e na adolescência pode favorecer sobremaneira o desenvolvimento ou a manutenção de níveis adequados de aptidão física, reduzindo o risco de incidência de inúmeras disfunções crônico-degenerativas em idades precoces. Assim, o propósito deste estudo foi analisar a adiposidade corporal e o desempenho motor em crianças de alto nível socioeconômico, de acordo com uma avaliação referenciada por critérios de saúde. Para tanto, 511 escolares (274 meninos e 237 meninas) de sete a 10 anos, foram submetidos a medidas antropométricas de massa corporal, estatura e espessuras de dobras cutâneas (tricipital e subescapular) e aos seguintes testes motores: sentar e alcançar (SA), abdominal modificado (ABD) e corrida/caminhada de nove minutos (9MIN). As informações foram analisadas de acordo com os pontos de corte sugeridos pelo Physical Best (1988). Com relação à adiposidade corporal, verificou-se maior contingente de escolares acima (33 por cento dos meninos e 15 por cento das meninas, P < 0,01) do que abaixo (7 por cento dos meninos e 15 por cento das meninas, P < 0,01) dos critérios preestabelecidos. O comportamento observado nos diferentes testes motores empregados foi bastante semelhante em ambos os sexos, com exceção do SA, no qual uma proporção maior de meninas atendeu ao critério adotado (76 por cento vs. 58 por cento, P < 0,01). Por outro lado, o desempenho motor mais fraco foi identificado no teste 9MIN, no qual somente 27 por cento dos meninos e 32 por cento das meninas (P > 0,05) alcançaram os pontos de corte adotados. Quando analisados conjuntamente, constatou-se que somente 15 por cento dos meninos e 21 por cento das meninas (P > 0,05) apresentaram resultados satisfatórios nos três testes motores utilizados. A alta prevalência de crianças que se situaram acima do critério de saúde para quantidade de gordura corporal, associada à baixa proporção de sujeitos que atenderam aos...

Regular practice of systematized physical activities in childhood and adolescence may strongly favor the development or maintenance of suitable levels of physical fitness, decreasing hence the risk of incidence of several chronic-degenerative dysfunctions in early ages. Thus, the aim of this study was to analyze the body adiposity as well as the motor performance in high socio-economical status children, according to an evaluation for health criterion reference. Therefore, 511 students (274 boys and 237 girls), age between 7-10 years were submitted to anthropometrical measurements of body weight, height and skinfolds thickness (tricipital and subscapular) as well as the following motor tests: sitting and reaching (SR); modified abdominal (ABD) and 9 minute-run/walk (9MIN). The data were analyzed according to the cutting points suggested by the Physical Best (1988). Concerning body adiposity; a higher number of students were verified above (33 percent of boys and 15 percent of girls, P < 0.01) than below the preestablished criteria. The observed behavior in the different motor tests applied was very similar in both sexes, except for the SR in which a higher proportion of girls fulfilled the adopted criteria (76 percent vs. 58 percent, P < 0.01). Conversely, the weakest motor development was identified in the 9MIN test where only 27 percent of the boys and 32 percent of the girls (P > 0.05) reached the adopted cutting points. When analyzed together, it was observed that only 15 percent of the boys and 21 percent of the girls (P > 0.05) presented satisfactory results in the three motor tests used. The high prevalence of children who were above the health criteria for the body fat amount, associated with the low proportion of subjects who fulfilled the established criteria in the used motor tests group, show that the physical fitness level found in the students investigated is fairly below the expectation. The results suggest the need of...