ABSTRACT
ObjectiveTo evaluate the clinical efficiency and safety of cefmetazon in the prevention Department of General Surgery,First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,Chinaand or treatment of infections in general surgery. MethodsA multicenter,prospective and open-labeled trial was conducted. In the prevention group,1700 patients were enrolled in clean-infection surgery,cefmetazon was given 1 g iv half an hour before the surgery started,and 1 g iv twice daily after the surgery for 3 days.Clinical response was evaluated in terms of both cure ( disappearance of pre treatment symptoms)and pathogen. In the treatment group,897 patients were diagnosed as peritonitis, cholecystitis and cholangitis,the patients were given cefmetazon 2 g iv twice a day for 7 - 14 days,clinical response and microbiological efficacy were assessed.ResultsIn prophylactic group,1449 patients were finally included.The clinical efficacy was 100％ (1449/1449).In the treatment group,a total of 897 patients were enrolled,and 110 patients failed for assessment of clinical efficacy,787 patients were included in the PPS population,the clinical efficacy was 90.7％ (714/787); Bacterial eradication rate was 92％ (46/50).Adverse reaction rates in prevention group and treatment group were 1.3％ (22/1700) and 1.2％ (11/897),including mild nausea and vomitting.ConclusionsCefmetazon is effective and safe in prevention and treatment of Postoperative infections in general surgery.
ABSTRACT
Objective To evaluate the efficacy and safety of intravenous cefmetazole in the treatment of patients with aspiratory pneumonia. Methods A multicenter, prospective and open-labeled trial was conducted. A total of 1522 patients were enrolled at the beginning, and only 1324 were evaluabled at the endpoint. The duration of treatment was 7-14 days. During the treatment and follow-up periods, we recorded any unexpected symptoms and abnormal laboratory tests. At last,we evaluated its efficacy and safety. Results The total effective rate of cefmetazole was 79. 8% (1056/1324). The total bacterial eradication rate was 75.0% ( 342/456 ) . The bacterial eradication rates of klebsiellar pneumonia, escherichia, staphyloccocus aureus and anaerobic bacteria were 78.2% (97/124), 80.8% (80/99), 89.0% (81/91), 9/11,respectively. Conclusions Cefmetazole is effective and safe in the treatment of aspiratory pneumonia.
ABSTRACT
OBJECTIVE To investigate in vitro activities of 12 antimicrobial agents including cefmetazole against extended-spectrum beta-lactamases-producing Escherichia coli(528 strains),Klebsiella pneumoniae(311 strains) and Proteus mirabilis(15 strains).METHODS They all collected from 15 teaching hospitals in China during 2005 and 2006 and included in the study.The levels of minimal inhibitory concentration(MIC) of 12 antimicrobial agents were determined by agar dilution method.WHONET 5.4 Software was used to analyze the data.RESULTS Against ESBLs-producing E.coli and ESBLs-producing K.pneumoniae,carbapenems were the most active antimicrobial agents(all 100.0% susceptible),followed by cephamycins(80.1-97.3%).Piperacillin/tazobactam(78.5-95.1%)showed a higher activity than cefoperazone/sulbactam(44.1-56.2%).The susceptible rate to ceftazidime against ESBLs-producing E.coli was remarkably higher than the other three cephalosporins,however the differences did not happen to ESBL-producing K.pneumoniae obviously.The susceptible rate to cefuroxime was below 1.6%.ESBLs-producing K.pneumoniae showed high sensitivity to carbapenems,cephamycins and ?-lactam/lactamase inhibitor combinations(all 100% susceptible),however the susceptible rates to cephalosporins were relatively lower.CONCLUSIONS Carbapenems and cephamycins remain the relatively high activity against ESBLs-producing Enterobacteriaceae.
ABSTRACT
OBJECTIVE:To study the compatible stability of gatifloxacin for injection with cefmetazole for injection in 0.9% sodium chloride injection versus in 5% glucose injection.METHODS:The changes in appearance and pH value and UV absorption spectra for the mixture of gatifloxacin for injection with cefmetazole for injection at room temperature(20?1)℃ with 8 hours were observed,and the contents of gatifloxacin and cefmetazole were determined by dual ultraviolet spectrophotometry.RESULTS:No marked change was noted for the mixture within 8 hours in appearance,pH value,contents and UV peak shape.CONCLUSION:Gatifloxacin for injection is compatible with cefmetazole for injection in 0.9% sodium chloride injection or 5% glucose injection.
ABSTRACT
Objective:To evaluate the curative effect and safety of domestic cefmetazole sodium for injection on moderate and severe bacterial infection of respiratory system.Methods:A clinical trial by randomized,double-blind,parallel control was conducted.The control drug was imported cefmetazole.Both groups were administered intravenously at a dose of 2 gram twice daily for 5 to 12 days.Results:A total of 48 patients were randomized into the treatment group and the control group,while 46 of them were enrolled in the statistical analysis of the clinical efficacy,with 24 patients in the treatment group and 22 in the control group.At the end of the treatment,the effective rate was 75.0% in the treatment group and 81.82% in the control one.The bacterial clearance rate and the drug-related adverse reaction rate were 88.89% and 8.33% in the treatment group,and 81.25% and 16.67% in the control one,respectively.There were no significant statistical differences between the two groups.Conclusion:Domestic cefmetazole sodium for injection was effective and safe in the treatment of bacterial infection of respiratory system.