ABSTRACT
Objective: To optimize the purification process of celandine in Celandine Alkali from Tong'an Injection, and to improve the content of celandine in Celandine Alkali extract. Methods: In order to select the best way to separate celandine acid liquid, a study was carried out in three different ways of separation such as plate straight association-like centrifuge, high speed tubular centrifuge, and disc centrifuge; We investigated the dissolving effect caused by different pH values of hydrochloric acid to celandine dry extract; Three separation methods on celandine acidic lysate were investigated to choose the best, such as vacuum filtration, high-speed centrifuge tube, and flat direct-coupled centrifugal. Celandine Alkali transfer rate, and dry paste rate were as used evaluation indexes, so as to determine the feasible celandine refining purification process. Results: It was the best way to separate celandine acid liquid by using disccentrifuge; Hydrochloric acid could have the best dissolving effect on celandine dry extract when the pH values were 3-4, and the transfer rate of chelidonine was also the highest; High-speed tubular centrifuge was the best separation method for the celandine acidic dissolution liquid. Conclusion: The optimized process is simple, stable and viable, and it could be used for the preparation of qualified celandine intermediates.