ABSTRACT
En este capítulo revisaremos cuatro importantes hitos en la salud preventiva de la mujer.Veremos las recomendaciones actuales de manejo del embarazo y atención del parto con los derechos de la mujer y las prácticas médicas recomendadas.Analizaremos los derechos reproductivos de la mujer y el viraje hacia la anticoncepción hormonal. El cáncer cervicouterino sigue siendo una patología prevalente y veremos como los programas de prevención son exitosos y analizaremos la nueva vacuna para virus papiloma. Finalmente revisaremos 2 tópicos de la mujer climatérica: la salud cardiovascular y la salud ósea
In this chapter we review four major milestones in women's preventive health. We will see the current recommendations for management of pregnancy and delivery care to the rights of women and medical practices recommended. Analyze the reproductive rights of women and the shift to hormonal contraception. Cervical cancer remains a prevalent disease and we will see how prevention programs are successful and we should analyze the new papillomavirus vaccines. Finally we will review two topics of climacteric women: cardiovascular health and bone health
Subject(s)
Humans , Female , Preventive Medicine , Women's Health , Osteoporosis/prevention & control , Prenatal Care , Menopause , Uterine Cervical Neoplasms , Risk Factors , Reproductive Health , ObstetricsABSTRACT
Objective To evaluate the therapeutic efficiency and side effect of concurrent radiotherapy and weekly chemotherapy with low-dose eisplatin(DDP) and 5-fluorouracil(5-FU) for advanced cervical canc-er. Methods 73 patients with advanced cervical cancer were randomized into two groups: 37 cases in the chemo-radiotherapy group received radiotherapy combined with DDP 40 mg and 5-FU 500 mg weekly for 6-7 weeks. 36 cases in the only radiotherapy group received radiotherapy alone. Radiotherapy was given with conven-tional fraction,the total tumor dose was 50 Gy. Results The rate of overall response and three-year survival and local recurrenc and distant metastasis for the chemo-radiotherapy group and the only radiotherapy group were 97.30%, 89. 19%, 8. 11% and 10. 81%, and those for the only radiotherapy group were 77.78%,66. 67% ,30.56% and 33.33%. The difference of the four groups was statistically significant ( P <0. 05). The rate of bone marrow inhibition and reaction of digestive tract in chemo-radiotherapy group were higher than those in simple radiotherapy group, but most reactions were grade 1 and grade 2, without statistically significant dife-renee between two groups. Conclusion Concurrent radiotherapy and weekly chemotherapy with low-dose cis-platin and 5-fluorouracil for advanced cervical cancer can significantly improve local control rate and survival rate, and have slight side effects.
ABSTRACT
Background and purpose:Survivin,a member of the inhibiter of apoptosis gene family,has been detected in fetal tissue and in variety of human malignancies.In the current study,we not only investigated the expression of a novel inhibitor gene of apoptosis,survivin in Cervixneoplasms but also studied its relationship between the expression of P53 and HPV-16. Methods:Using streptavidin-bintin peroxidase(SP)method,We examinined the expression of the proteins survivin , p53 and HPV-16 in 21 normal cervical tissues ,33 CIN and 72 cervical cacinoma tissues.Results:Survivin was expressed in 52 of 72(72.2%) cases of cervical carcimomas ,however,it was not expressed in normal cervical tissues and it was expressed in6 of 33(18.18%)cases of CIN. Overexpression of survivn was related to the tumor grade and clinical stage.Survivin positive cases were strongly associated with p53 expression (P