ABSTRACT
Objective To explore the chronergy of fibrinolysin and its influence on fibrinogen ( FIB ) and thrombus precursor protein (TpP) in treatment of acute cerebral infarction (ACI). Methods The clinical trial adopted the randomized single-blind placebo-controlled design.Totally, 150 patients with ACI (onset time≤12 h) were chosen and randomly divided into experimental group A ( group A receiving treatment of fibrinolysin after 12 h onset of ACI ) , experimental group B ( group B receiving treatment of fibrinolysin after 24 h onset of ACI) and control group ( group C without fibrinolysin treatment) , 50 cases in each group.The patients in experimental group A and B received basic treatment for ACI and fibrinolysin treatment.Patients in group C were given the basic treatment for ACI and placebo.The level of FIB and TpP before and after 7 days treatment, NIHSS scores before and after 14 days treatment, BI scores before and after 90 days treatment, incidence rate of progressive cerebral infarction ( PCI ) , stroke recurrence and mortality rate of the three groups were analyzed to evaluate the clinical effect of fibrinolysin.Hepatic and renal function before and after 7 days treatment, incidence rates of haemorrhage and hypersensitiveness were analyzed to evaluate the security of fibrinolysin. Results The NIHSS score of patients in group A, B and C (4.0±1.6, 6.5±2.2 and 8.0±4.7) was declined significantly after treatment (P0.05).The FIB in group A, B and C after treatment was (2.74±0.75) g?L-1,(2.82±0.83) and (3.67±1.35) g?L-1, respectively.The level of FIB in the three groups did not decrease significantly after treatment (P>0.05).However, the level of FIB in group A and B declined significantly as compared with that in group C.The TpP in group A, B and C after treatment was (3.56±1.26) mg?L-1, (3.43±1.22) and (13.21±6.54) mg?L-1, respectively.The level of TpP in group A and group B decreased significantly after treatment (P<0.05). The level of TpP in group A and B declined even more significantly than that in group C.Fibrinolysin did neither obviously injure liver and kidney nor increase the risk of bleeding, and had low hypersensitiveness incidence rate. Conclusion Treatment with fibrinolysin within 24 h after onset of cerebra infarction benefits the patients. However, dosing after 12 h onset of ACI benefits more than dosing after 24 h.Fibrinolysin plays a role of anti-thrombosis primarily by lowering the TpP level, and its influence on fibrinogen is limited.
ABSTRACT
OBJECTIVE:To observe the effect of room temperature and low temperature storage on the chronergy of domes-tic cisatracurium. METHODS:90 patients undergoing elective surgery under general anesthesia were randomly divided into low tem-perature group,room temperature A group and room temperature B group,with 30 cases in each groups. Through single supramaxi-mal electrical stimulation of the adductor pollicis muscle,TOF-Watch SX muscle relaxation monitor was used to observe the degree of muscle relaxation. After induction of anesthesia and lost consciousness,the patients was given intravenous injection of cisatracu-rium 0.2 mg/kg;when muscle twitch decreased to the maximum inhibition degree,the patient received endotracheal intubation. The cisatracurium of low temperature group was stored in refrigerator at 2 to 5℃;that of room temperature A group and room tempera-ture B group was stored in incubator for 15 days or 30 days. The onset time,maximum inhibition degree of muscle twitch,clini-cal duration,recovery index and total chronergy were recorded in 3 groups. RESULTS:The maximal inhibition degree of muscle twitch reached 0 under the action of cisatracurium. There was no statistical significance in onset time and clinical duration between room temperature A group,room temperature B group and low temperature group(P>0.05);the recovery index and total chroner-gy of room temperature A group and room temperature B group were or longer than low temperature group,with statistical signifi-cance(P<0.05). CONCLUSIONS:Domestic cisatracurium stored at low temperature shows weaker effect on muscle relaxation.
ABSTRACT
After defining chronergy for medical instruments maintenance,this paper generalizes the importance of maintenance chronergy,and puts forward some specific methods for its improvement.