ABSTRACT
Se realizó un estudio experimental en 150 pacientes con indicación de test de proteinuria, atendidos en el Hospital Provincial Oncológico Conrado Benítez de Santiago de Cuba desde junio de 2004 hasta mayo de 2005, a fin de determinar la relación existente entre los valores de proteinuira obtenidos en muestra simple de orina, mediante la fórmula derivada de Cockroft-Gault y el método tradicional. Los resultados revelaron que el método propuesto resultó tan eficaz como el tradicional y además de representar un ahorro de tiempo y reactivos, evitó inexactitudes y molestias por la obtención de orina durante 24 horas, de modo que proporciona al especialista datos confiables, a lo cual se suma que es más rápido y fácil de ejecutar.
An experimental study was carried out in 150 patients with indication of proteinuria test, attended in Conrado Benítez Provincial Oncology Hospital of Santiago de Cuba from June, 2004 to May, 2005, in order to determine the relationship between proteinuira values obtained in a simple urine specimen by means of the derivative formula of Cockroft-Gault and the traditional method. Results revealed that the proposed method was as effective as the traditional one, and besides representing a saving of time and reagents it prevented inaccuracies and trouble for the urine collection during 24 hours, so that it provides the specialist with reliable data, and it is quicker and easier to use.
Subject(s)
Humans , Male , Female , Proteinuria , Proteinuria/urine , Secondary Care , Urine , Clinical TrialABSTRACT
Objective: To evaluate the association of microalbumin, estimated creatinine clearance (eCrCl), and the other variables in type 2 diabetes (T2D) patients for the prediction of early nephropathy. Methods: Fasting plasma glucose, serum BUN, total cholesterol (TC), triglyceride (TG), HDL-C, serum creatinine, and urine microalbumin were measured with a Hitachi 912 autoanalyzer as microalbumin/gram of creatinine (g CT). The Cockroft-Gault formula was used to calculate the eCrCl and the eCrCl was subdivided as defined by the Kidney Disease Outcome Quality Initiative. Results: In a total of 93 patients, these were 50 patients having T2D and 43 control patients having non-diabetes (NDM). The T2D patients were significantly higher in systolic, diastolic blood pressure, serum creatinine, and urine microalbumin than the NDM patients (P<0.05), and the T2D patients were significantly lower in eCrCl than the NDM patients (P<0.001). The eCrCl was significantly reverse correlated with the duration of abnormal glucose metabolism and age (P<0.05). Conclusion: The eCrCl is important in T2D patients. A decrease in eCrCl with or without an increase in microalbumin excretion may be the universal indication of the presence of diabetic glomerular pathology.
ABSTRACT
BACKGROUND: The urinary protein to creatinine ratio in a single voided random urine sample has been widely used as an estimation of 24 hour urine protein excretion because of inconvenience and frequent collection errors during timed collection of 24 hour urine. But the protein to creatinine ratio also showed frequent estimating error, overestimation or underestimation. We thought that protein to creatinine ratio adjusted by daily creatinine excretion estimated by Cockroft-Gault equation can be more accurate than protein to creatinine ratio and compared them as follows. METHODS: This study consisted of 81 patients whose 24 hour urine protein excretion and random spot urine protein to creatinine ratio were measured concomitantly. There was no significant change of body weight or serum creatinine change around the study day. The modified protein to creatinine ratio could be estimated from the measured protein to creatinine ratio in a random spot urine sample by multiplying the ratio by the expected daily creatinine excretion estimated by Cockroft-Gault equation. These results were compared with well collected 24 hour urine protein. RESULTS: The difference between protein to creatinine ratio and 24 hour urine protein was 0.87+/-1.13, on the other hand, the difference between modified protein to creatinine ratio and 24 hour urine protein was 0.52+/-0.65 (p<0.05). Correlation coefficients between protein to creatinine ratio, modified protein to creatinine ratio and 24 hour urine protein were 0.877, 0.957 respectively. CONCLUSION: The protein to creatinine ratio modified by the expected daily creatinine excreation rate calculated by Cockfort-Gault equation was more accurate than simple protein to creatinine ratio.