Sleep duration, insomnia and cognitive performance in the Elsa-Brasil cohort: a cross-sectional analysis / Duração do sono, insônia e desempenho cognitivo na coorte Elsa-Brasil: uma análise transversal

ABSTRACT Objective: To investigate the single and combined associations between sleep disturbances (sleep duration, insomnia symptoms in the last 30 nights, and daytime tiredness) and performance in cognitive tests. Methods: Cross-sectional analysis of data from visit 2 (2012-2014) of the Longitudinal Study of Adult Health from a cohort of active and retired civil servants from six Brazilian capitals. Polynomial regression with quadratic term and multiple linear regression models were performed to assess single and combined associations between sleep disturbances and memory performance, fluency, executive functions, and global cognition. Results: A total of 7,248 participants were included, with a mean age of 62.7 years (standard deviation [SD]=5.9), and 55.2% were women. Inverted U-shaped associations were observed between sleep duration and performance on all cognitive abilities, suggesting that durations shorter or longer than seven hours are associated with worse performance, regardless of age. Reported insomnia was associated with worse executive function (β: -0.08; 95% confidence interval [CI]: -0.15 to -0.01), and the magnitudes of associations were higher for individuals with insomnia at two or more moments (β: -0.12; 95%CI -0.19 to -0.05) or, especially, insomnia combined with short sleep (β: -0.18; 95%CI -0.24 to -0.11). Insomnia in two or more periods was also associated with lower memory and global cognition. There was no association between any sleep disturbance tested and verbal fluency. Isolated daytime tiredness was not associated with performance in the evaluated tests. Conclusion: The results suggest that extreme sleep durations are detrimental to almost all cognitive abilities investigated, whereas insomnia appears to affect more severely the executive function.

RESUMO Objetivo: Investigar a associação isolada e combinada entre distúrbios do sono (duração do sono, sintomas de insônia nas últimas 30 noites e cansaço diurno) e desempenho em testes cognitivos. Métodos: Análise transversal dos dados da visita 2 (2012-2014) do Estudo Longitudinal de Saúde do Adulto de coorte de servidores públicos ativos e aposentados de seis capitais brasileiras. Regressão polinomial com termo quadrático e modelos de regressão linear múltipla foram realizados para avaliar associações isoladas e combinadas entre distúrbios do sono e desempenho na memória, fluência, funções executivas e cognição global. Resultados: Foram incluídos um total de 7.248 participantes, com média etária de 62,7 anos (desvio padrão [DP]=5,9), sendo 55,2% mulheres. Associações em forma de U invertido foram observadas entre duração do sono e desempenho em todas as habilidades cognitivas, sugerindo que durações menores ou maiores que sete horas estão associadas ao pior desempenho, independentemente da idade. O relato de insônia foi associado à pior função executiva (β: -0.08; IC95% -0.15 a -0.01), sendo as magnitudes das associações maiores para indivíduos com insônia em dois ou mais momentos (β: -0.12; intervalo de confiança [IC]95% -0.19 a -0.05) ou, especialmente, insônia combinada com sono curto (β: -0.18; IC95% -0.24 a -0.11). Insônia em dois ou mais períodos também foi associada à menor memória e cognição global. Não houve associação entre qualquer distúrbio do sono testado e fluência verbal. Cansaço diurno isolado não foi associado ao desempenho nos testes avaliados. Conclusão: Os resultados sugerem que a duração extrema do sono é prejudicial para quase todas as funções cognitivas investigadas, enquanto a insônia parece afetar mais fortemente a função executiva.

Mood states and cognitive performance in patients with complete spinal cord injury / 中国康复理论与实践

ObjectiveTo investigate the mood states, cognitive performance and the factors related to cognitive function of patients with complete spinal cord injury. MethodsA total of 60 male patients with complete spinal cord injury (SCI) admitted to Beijing Bo'ai Hospital from November, 2020 to March, 2022 were selected as SCI group, and 30 healthy males were selected as the control group. They were assessed with Montreal Cognitive Assessment Beijing Version (MoCA), Digital Span Test (DST) of Wechsler Memory Scale, Symbol Digit Modalities Test-Oral Version (SDMT), Rey-Osterrieth Complex Figure Test-30 min recall (CFT), Stroop Color-Word Test Chinese Version (CWT), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). ResultsCompared with the control group, the SDMT and CFT scores were significantly lower (t > 3.052，P < 0.01); the reflect and square root transformation of MoCA score, the square root transformation of Stroop interference effects time consuming, HAMA score and HAMD score were higher (|t| > 2.542, |Z| > 7.676, P < 0.05) in SCI group. Multiple linear regression analysis indicated that age, education level, HAMD score and sleep disorder were significantly correlated with the scores of cognitive function in SCI group. ConclusionThere are more intensive anxiety and depression in patients with complete SCI. The patients with complete SCI present cognitive impairment, especially in information processing speed, visuospatial ability and visual memory, and executive function. Age, education level, depression and sleep disorder are the related factors of cognitive impairment in patients with complete SCI.

Can high pain intensity and catastrophizing interfere with the cognitive performance of women with chronic pain related TMD? A cross-sectional study

Abstract Interventions based on pain education and self-management are dependent on factors such as attention, memory, concentration, and executive function. Objective To explore the relationship between cognitive performance and the variables pain intensity, central sensitization, catastrophizing, and hypervigilance in women diagnosed with chronic pain-related TMD. Methodology This is a cross-sectional study. A total of 33 women (mean age: 38±4.6 years; range: 18 to 66 years) with chronic pain-related TMD (myalgia and/or arthralgia) diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Specific questionnaires were used to evaluate cognitive performance, overall pain intensity, central sensitization, hypervigilance, and pain catastrophizing. The data were analyzed using Pearson's correlation coefficient and backward stepwise multiple linear regression (statistical significance at 5% alpha). Results Approximately 53% of the study sample showed decreased cognitive performance. High central sensitization, hypervigilance, and pain catastrophizing were observed. A significant negative correlation was observed between cognitive performance and hypervigilance (p=.003, r=−.49), cognitive performance and catastrophizing (p<.001, r=−.58), and cognitive performance and pain intensity (p<.001, r=−.58). Regarding the partial regression coefficients, only catastrophizing and pain intensity showed statistical significance (t=−2.12, p=.043; t=−2.64, p=.014, respectively), indicating a significant role in explaining cognitive performance at the sample. Conclusion High pain intensity and the presence of catastrophic thoughts regarding pain can predict impaired cognitive performance in women with chronic pain-related TMD. Management strategies addressing psychosocial dimensions such as reducing catastrophizing and ensuring complete understanding of the condition are important.

Changes In Emotional Distress And Cognitive Performance Following Aerobic Exercise And Low Fat Milk Consumption In Sedentary Female Adolescents

@#Introduction: Regular aerobic exercise and low-fat milk consumption can improve certain cognitive functions and reducing emotional distress. However, the impacts of combining these modalities are less explored. Thus, the present study examined the effects of combining aerobic exercise and low-fat milk intake among sedentary female students. Methods: Using a nonrandomized pretest – posttest with a control group research design, 85 sedentary females aged 16 years old were assigned into either milk (n = 21), exercise (n = 22), combined low fat milk and exercise (n = 23), or control (n = 19) groups. One serving of low-fat milk was provided to the students during each school day, and a 1-hour supervised step aerobics exercise was conducted twice per week for 3 months. Emotional distress and sustained attention were measured at baseline, 6th and 12th weeks after the intervention. A mixed factorial ANOVA was used to analyse the data. Results: The results revealed significantly less emotional distress in the combined (p < 0.01) and exercise groups (p < 0.05) compared with the control group after 12 weeks. Additionally, significant reductions were observed in the total time taken and errors of omission for both digits 6 and 9 of the Digit Vigilance Test in the combined group (p < 0.05, p < 0.001) compared with the control group. Conclusions: The results showed that low fat milk alone did not provide any additional benefits related to distress regulation, but the combination of exercise and low-fat milk contributed to improving sustained attention.

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review (Kesan Gangguan Ritma Sirkadian terhadap Stres Metabolik dan Kesihatan Mental: Satu Tinjauan Kepustakaan / Jurnal Sains Kesihatan Malaysia

@#This review aims to present an overview of current research findings on the possible effects of circadian rhythm (CR) disruption towards metabolic stress and mental health. CR can be described as an internal biological clock that regulates our body functions, based on our sleep/wake cycle. Any time that our normal 24-hour circadian rhythm is altered or interrupted, it will have physiological and psychological impacts. However, in today’s demanding working world, most of us are working defying the normal conditions without realising the significant drawbacks of it. Therefore, this review summarises the findings from several researches on the physiological (metabolic stress) and psychological (cognitive functioning and mental health) impacts of the CR disruption in order to assist people to have a holistic view on the effects of CR to our mind and body. Evidences that linked these aspects to health circumstances of shift workers have also been highlighted.

Neurobiological factors of trait anxiety and its influences on individual cognitive performance / 中国临床药理学与治疗学

Trait anxiety is a relatively stable anxiety tendency with individual differences in personality traits. The level of trait anxiety is related to gene polymorphism, oxidative stress, and brain volume and brain chemicals. At the same time, trait anxiety can affect an individual's cognitive performance, such as the extinction of fear memories and the process of threat-related information. Fully understanding the neurobiological factors of trait anxiety and its impacts on individual cognitive performance can help us cope with life events better and prevent or treat anxiety, depression and other mental illnesses more effectively.

Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil

Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants ≥50 years of age without a known diagnosis of dementia and a self-reported glaucoma diagnosis. We excluded those with previous stroke, other eye conditions, and using drugs that could impair cognition. We evaluated cognition using delayed word recall, phonemic verbal fluency, and trail making (version B) tests. We used multinomial linear regression models to investigate associations between self-reported glaucoma with cognition, adjusted by several sociodemographic and clinical variables. Out of 4,331 participants, 139 reported glaucoma. Fully-adjusted models showed that self-reported glaucoma patients presented poorer performance in the verbal fluency test (β=-0.39, 95%CI=-0.64 to -0.14, P=0.002), but not in the other cognitive assessments. Thus, our results support the hypothesis that self-reported glaucoma is associated with poor cognitive performance; however, longitudinal data are necessary to corroborate our findings.

Diferencias en la reserva neural en relación al entrenamiento musical / Differences in the neural reserve in relation to music training

La reserva neural es un subcomponente de la reserva cognitiva y refiere a las diferencias en los paradigmas cognitivos que subyacen al desempeño de tareas en un cerebro sano. Puede darse por diferencias innatas (inteligencia, edad) o ambientales, como el entrenamiento musical. Éste está relacionado con diferencias cerebrales y cognitivas. El objetivo del presente estudio es realizar una revisión bibliográfica de investigaciones que evaluaron rendimiento cognitivo en músicos como no músicos, y establecer diferencias en la reserva cognitiva y, más específicamente, el subcomponente de reserva neural, entre ambos grupos. Se parte de la suposición de que los músicos poseen un rendimiento superior en tareas cognitivas con respecto a los no músicos y que esto está relacionado con una mayor reserva neural debido al entrenamiento musical. Los resultados son contradictorios. Se encontraron algunas diferencias en dominios cercanos a la práctica musical en adultos jóvenes, y en diversos dominios en adultos mayores. Las diferencias entre grupos, que no diferían en inteligencia, podrían ser atribuibles a una mayor reserva cognitiva. También hay relaciones con el tipo de instrumento, los años y la edad de comienzo de la práctica musical. Se sugiere replicar los hallazgos controlando diversas variables(AU)

Neural reserve is a subcomponent of cognitive reserve and refers to the differences in cognitive paradigms that underlie task performance in a healthy brain. It can occur due to innate (intelligence, age) or environmental differences, such as musical training. This is related to brain and cognitive differences. The aim of the present study is to carry out a bibliographic review of investigations that evaluated cognitive performance in musicians as well as non-musicians, and to establish differences in cognitive reserve and, more specifically, the neural reserve subcomponent, between both groups. It is assumed that musicians have superior cognitive tasks performance compared to non-musicians and that this is related to a greater neural reserve due to musical training. The results are contradictory. Some differences were found in domains close to musical practice in young adults, and in various domains in older adults. The differences between groups, which did not differ in intelligence, could be attributable to a greater cognitive reserve. There are also relationships with the type of instrument, the years and the age of beginning of the musical practice. It is suggested to replicate the findings controlling for various variables(AU)

Cupremia y colesterolemia como factores de riesgo en pacientes con enfermedad de Alzheimer / Plasma levels of copper and cholesterol as risk factors in Alzheimer disease patients / Cupremia e colesterolemia como fatores de risco em pacientes com doença de Alzheimer

Se estudiaron 241 personas, 119 controles y 122 pacientes con enfermedad de Alzheimer (EA) subagrupados en tres categorías de acuerdo con el estadio clínico de la dolencia, con el objetivo de investigar la influencia de niveles elevados de cobre libre y colesterol plasmático como factores de riesgo para la EA. Las conclusiones obtenidas de los resultados indicaron que los pacientes expuestos a una combinación de alto colesterol y de cobre no unido a ceruloplasmina tuvieron mayor proporción de marcadores de estrés oxidativo (carbonilos proteicos, sustancias reactivas al tiobarbiturato, glutatión oxidado y descenso de antioxidantes totales en sangre), conjuntamente con un incremento de HDL-colesterol peroxidado y lipoproteína "a" que correlacionó con la gravedad de su cuadro. Lo mismo sucedió con la relación entre péptidos amiloides (1-40) y (1-42) en plasma y los valores del mini-test de estado cognitivo (MMSE). Se halló que una función de adición de efectos que cuantificó el daño por cobre libre y colesterol oxidado resultó directamente proporcional a la pérdida de desempeño cognitivo estimada por medio del MMSE. Esta función es de fácil determinación y puede considerarse un nuevo biomarcador para estudiar riesgo en poblaciones expuestas, apoyar el diagnóstico clínico, o evaluar la eficacia de estrategias terapéuticas en pacientes con EA.

Alzheimer disease (AD) patients (122) compared to control subjects (119) were studied to determine the role of chronic exposure of hypercholesterolemic plasma levels and free copper (not bound to ceruloplasmin) as biomarkers of progression for AD. Oxidative stress parameters, lipid profile, amyloid levels, and cognitive status were studied in all participants. Conclusions obtained indicated that patients exposed simultaneously to free copper and increased cholesterol levels present higher indicators of oxidative stress (protein carbonyls, thiobarbituric acid-reactive substances, decreased total antioxidant activity in plasma and elevated oxidized HDL-cholesterol). Lipoprotein "a" concentrations also correlated with the clinical progression of the disease. The ratio amyloid ß(1-40)/ß(1-42) in plasma inversely correlated with the cognitive performance estimated by the Mini-Mental State Examination Test (MMSE). A defined function that weighs the contribution of the deleterious effect produced by combined free copper and Ox-HDL-cholesterol exposure directly correlated with the loss of cognitive performance. Thus, this biomarker could be a new tool for the screening of large populations under risk, or may be a useful way to estimate the efficacy of therapeuti approaches in patients suffering AD.

Foram estudadas 241 pessoas, 119 controles e 122 pacientes com doença de Alzheimer (DA), agrupados em três categorias de acordo com o estágio clínico da doença, com o objetivo de investigar a influência de níveis elevados de cobre livre e colesterol plasmático como fatores de risco para a DA. As conclusões obtidas a partir dos resultados indicaram que os pacientes expostos a uma combinação de colesterol alto e de cobre não ligados à ceruloplasmina apresentaram maior proporção de marcadores de estresse oxidativo (carbonilos proteicos, substâncias reativas ao tiobarbiturato, glutationa oxidada e diminuição dos antioxidantes totais no sangue ), juntamente com um aumento da HDL-colesterol peroxidado e lipoproteína "a" que correlacionou com a gravidade de sua condição. O mesmo aconteceu com a relação entre os peptídeos amilóides (1-40) e (1-42) em plasma e os valores do mini-teste do estado cognitivo (MMSE). Verificou-se que uma função de adição de efeitos que quantificou o dano por cobre livre e colesterol oxidado resultou diretamente proporcional à perda de desempenho cognitivo estimada através do MMSE. Esta função é fácil de determinar e pode ser considerada um novo biomarcador para estudar o risco em populações expostas, apoiar o diagnóstico clínico ou avaliar a eficácia de estratégias terapêuticas em pacientes com DA.

Evaluación neuropsicológica básica para adultos en pacientes con trastorno de ansiedad generalizada / Basic neuropsychological evaluation for adults in patients with generalized anxiety disorders

Resumen Introducción: El desempeño en el funcionamiento cognitivo de pacientes con Trastorno de Ansiedad Generalizada (TAG) ha recibido poco interés y los resultados de algunos estudios han demostrado ser poco consistentes. Objetivo: Conocer el desempeño de las funciones cognitivas de sujetos con Trastorno de Ansiedad Generalizada y comparar con sujetos sin ansiedad clínica, a través de la Evaluación Neuropsicológica Básica para Adultos (ENBA). Método: Un diseño transversal, con muestreo intencionado, se estudiaron 23 sujetos con único diagnóstico de TAG y un grupo control de 23 sujetos pareados según sexo, edad y escolaridad. Resultados: El grupo con TAG obtuvo un peor desempeño estadísticamente significativo (p = < 0,05) en algunas puntuaciones de la ENBA que evalúan habilidades de construcción visuoespacial, memoria visual, memoria verbal y aprendizaje, atención y funciones ejecutivas. Conclusiones: Los resultados son parcialmente consistentes con estudios previos. El conocimiento de las alteraciones cognitivas en sujetos con TAG es útil para comprender los efectos nocivos en áreas importantes como la laboral, académica, y otras, descritos en dichos pacientes.

Introduction: The performance in cognitive functioning of patients with Generalized Anxiety Disorder (GAD) has received little interest and the results of some studies have been shown to be inconsistent. Objective: To know the performance of the cognitive functions of subjects with Generalized Anxiety Disorder and to compare it with subjects without clinical anxiety, through the Evaluación Neuropsicológica Básica para Adultos (ENBA). Method: A cross-sectional design, using convenience sampling, 23 subjects with a single diagnosis of GAD and a control group of 23 subjects matched according by sex, age, and education were studied. Results: The group with TAG obtained a worse statically significant performance (p = < 0,05) in some scores of the ENBA that assess abilities of visuospatial construction, visual memory, verbal memory and learning, attention and executive functions. Conclusions: The results are partially consistent with previous studies. The knowledge of the cognitive impairments in subjects with TAG is useful to understand the harmful effects in important areas such as employment, academic activities, among others described in these patients.

Cardiovascular risk factors and cognitive performance in aging / Fatores de risco cardiovascular e desempenho cognitivo no envelhecimento

ABSTRACT. Background. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. Objective: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. Methods: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. Results: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. Conclusion: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging.

RESUMO. Introdução: A aterosclerose nos vasos sanguíneos cerebrais, especialmente naqueles que compõem o Círculo de Willis, pode levar à redução da oferta de oxigênio e nutrientes para diferentes estruturas corticais, afetando a função cognitiva. Objetivo: Analisar se fatores de risco cardiovascular influenciam negativamente o desempenho cognitivo em adultos e idosos. Métodos: Foram incluídos cento e vinte e nove participantes de ambos os sexos, com idade superior a 50 anos, sem comprometimento cognitivo ou funcional. Índice de massa corporal (IMC), hipertensão arterial (HAS), diabetes mellitus (DM), história de tabagismo, níveis plasmáticos de colesterol total e lipoproteínas de baixa densidade (LDL), lipoproteínas de alta densidade (HDL) e lipoproteínas de baixa densidade (VLDL), triglicerídeos e glicemia foram os fatores de risco cardiovascular analisados. A avaliação cognitiva foi realizada utilizando testes de atenção, memória operacional, fluência verbal e memória declarativa. Resultados: Controlando para idade e escolaridade, os modelos de regressão linear multivariada revelaram que concentrações mais elevadas de triglicerídeos, bem como colesterol total, LDL e VLDL, estão associadas com pior desempenho nos testes de extensão de dígitos e fluência verbal. Além disso, concentrações maiores de HDL se correlacionaram com pontuações maiores nas tarefas de fluência verbal. IMC maior se associou com menor desempenho na evocação tardia. Conclusão: Os achados revelaram que fatores de risco cardiovascular podem afetar negativamente o desempenho cognitivo durante o envelhecimento.

Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance / Impacto da gravidade da hipertensão na rigidez arterial, vasorreatividade cerebral e desempenho cognitivo

ABSTRACT. Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. Objective: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension. Methods: 211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological (NPE) tests were used to determine cognitive function. Pulse wave velocity was measured using the Complior®. Carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. Middle cerebral artery flow velocity was measured by transcranial Doppler ultrasonography. Results: Both arterial stiffness parameters and cerebral vasoreactivity worsened in line with HTN severity. There was a negative correlation between breath holding index (BHI) and arterial stiffness parameters. Cognitive performance worsened in line with HTN severity, with statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE and MoCA. The same tendency was observed on the NPE tests. Conclusion: Hypertension severity was associated with higher AS, worse BHI, and lower cognitive performance.

RESUMO. A idade, hipertensão arterial (HA), e outros fatores de risco cardiovascular contribuem para as alterações estruturais e funcionais da parede arterial. Objetivo: Avaliar o quanto a rigidez arterial está relacionada com as alterações do fluxo sanguíneo cerebral e sua associação com a função cognitiva em pacientes com hipertensão. Métodos: Foram incluídos 211 pacientes (69 normotensos e 142 hipertensos). Os pacientes com hipertensão foram divididos em dois estágios: HA-1 e HA-2. O mini exame do estado mental (MEEM), Montreal Cognitive Assessment (MoCA) e uma bateria de testes neuropsicológicos foram usados para avaliar a função cognitiva. A velocidade da onda de pulso foi medida usando o Complior®. As propriedades da artéria carótida foram avaliadas usando o ultrassom de radiofrequência. A pressão arterial central e o índice de incremento foram obtidos usando a tonometria de aplanação. A velocidade de fluxo sanguíneo da arterial cerebral média foi medida pelo ultrassom com Doppler Transcraniano. Resultados: Tanto os parâmetros da rigidez arterial quanto a vasorreatividade cerebral foram piores com a gravidade da hipertensão. Houve uma correlação negativa entre o índice de apnéia e os parâmetros da rigidez arterial. O desempenho cognitivo foi pior com a gravidade de hipertensão arterial com diferença estatística ocorrendo principalmente entre os grupos HA-2 e normotensão tanto no MEEM quanto no MoCA. A mesma tendência foi observada em relação aos testes neuropsicológicos. Conclusão: A gravidade de hipertensão arterial foi associada com maior rigidez arterial, pior índice de apneia, e menor desempenho cognitivo.

Estilos de personalidad dependiente y autocrítico: desempeño cognitivo y sintomatología depresiva / Dependent and self-critical personality styles: Cognitive performance and depressive symptomatology

Resumen El presente estudio explora la relación entre las dimensiones de personalidad dependiente y autocrítica, con los déficits emocionales, cognitivos y sociales asociados a la sintomatología depresiva. La muestra del estudio la conformaron 91 estudiantes universitarios pertenecientes a la Pontificia Universidad Católica de Chile y a la Universidad de Chile, con edades comprendidas entre los 18 y 24 años. Para explorar el estado emocional de los participantes se utilizaron los test Inventario de Depresión de Beck (BDI) y Depressive Experiences Question naire (DEQ). Con el fin de evaluar el desempeño cognitivo, se utilizaron: una tarea tipo Stroop y la prueba de Tiempo de Reacción Serial (SSRT), y para evaluar el nivel de mentalización, la tarea de reconocimiento facial Reading the Mind in the Eyes Task (RMET) de Baron-Cohen. Se encontraron correlaciones significativas entre las dimensiones dependencia y autocrítica, la sintomatología depresiva y el desempeño cognitivo de los participantes.

Abstract This study examines the relationship between the dependent and self-criticism Cognitive dimensions of personality with emotional, cognitive and social deficits associated with depres-sive symptoms. The sample included 91 college students, aged 18 to 24, from Pontificia Universidad Católica de Chile and Universidad de Chile. The Beck Depression Inventory (BDI) and the Depressive Experiences Questionnaire (DEQ) tests were used in order to explore the emotional state of the participants. A Stroop task and a Serial Reaction Time (SSRT) test were used in order to assess cognitive performance. In turn, the Reading the Mind in the Eyes Task (RMET) face recognition task, by Baron-Cohen, was used to assess the mentalising capacity. Sig nificant correlations were found between dependency and self-criticism dimensions, depressive symptoms and cognitive performance of the participant.

Factores predictores de la reserva cognitiva en un grupo de adultos mayores / Predictors of cognitive reserve in a group of elderly

El objetivo de este estudio fue identificar los factores predictores de la Reserva Cognitiva (RCog) medida a través del rendimiento cognitivo en un grupo de adultos mayores inscritos a un programa de atención integral al adulto mayor. La muestra estuvo conformada por 30 adultos mayores de 60 años. Se tuvieron en cuenta 8 factores predictores de la RCog basados en el cuestionario de Rami et al. (2011) y la medición del índice de Coeficiente Intelectual (CI). El rendimiento cognitivo fue medido a través de laBatería Neuropsi. Se realizaron análisis de correlación y de regresión múltiple entre factores. El factor escolaridad correlacionó significativamente con Formación intelectual y Actividad lectora (p<0,05). Las variables predictoras significativas del rendimiento cognitivo fueron Escolaridad y CI predictores del 62.9 por ciento de la varianza (r2 = 65.4; p<0.02). Se soporta la idea de que la capacidad intelectual y el nivel educativo son los predictores más fiables de la RCog y podrían retrasar el declive cognitivo propio del envejecimiento.(AU)

The goal of this study was identify the predictors factors of cognitive reserve (CogR) measured through the congnitive performance of an elderly persons group registered in an integral care program. The sample was built taking 30 adults of sixty years old.CogR predictors factors were taken in consideration, based in the questionnaire of Rami et al., (2011) and measuring of the intelligence quotient index (IQ). The cognitive performance was measured through the Neuropsi Battery. Correlation analysis and the analysis of multiple regression between factors were done. The education factor correlated significantly with intellectual education and reading activity (p<0.05). The strongest predictical variables of the cognitive performance were the school level and IQ. Both, predicted the 62.9 percent of the variance (r2 = 65.4; p<0.02). The idea that the intellectual capacity and education level are the most reliable predictors of the CogR is reliable and could delay the cognitive decline of aging.

Working memory dysfunction in insomniac adults: a systematic metanalytical review / Disfunção da memória de trabalho em adultos insones: uma revisão sistemática

BACKGROUND: Insomnia is the most commonly occurring sleep disorder: recent reports estimate that 25-30% of adults in the general population occasional instances of experience insomnia, while 10% suffer from disturbances severe enough to meet diagnostic criteria for insomnia. Little is known about the mechanisms, causes, clinical course, and consequences of this condition. Over 30 studies have been published on the matter but only a small proportion has found differences in the working memory of individuals with vs. without insomnia. OBJECTIVE: To summarize evidence regarding the differences in working memory performance between insomniac vs. normal adult sleepers. METHODS: The survey was conducted using an advanced search in the ISI Web of Science and MEDLINE/PubMed with the terms "sleep", "insomnia" and "working memory" as major descriptors; these were crossed with the following keywords: "psychological tests", "neuropsychology" and "performance". RESULTS: A total of 112 articles were identified in the search conducted in PubMed and Web of Science. After the screening, 102 articles unrelated to the proposed theme were excluded. Thus, 10 articles were analyzed by the eligibility and exclusion criteria, and included in this systematic review. CONCLUSION: The information resulting from the analysis of the reviewed articles suggests that mild, but not definitive deficits in cognitive performance might be masked by insignificant disparities in studies comparing insomniac individuals with normal sleepers. This shortcoming can be circumvented by larger and better-characterized samples, together with optimized methodological control of factors which might otherwise result in confounding variations among participants.

INTRODUÇÃO: A insônia é o distúrbio do sono mais comum: relatórios recentes estimam que 25-30% dos adultos sofrem episódios de insônia, enquanto 10% sofrem de distúrbio do sono suficientemente grave para cumprir os critérios de diagnóstico para insônia. Além disso, pouco se sabe sobre os mecanismos, causas, evolução clínica, e consequências desta doença crónica altamente prevalente. Mais de 30 estudos foram publicados sobre o assunto, mas apenas uma pequena proporção encontrou diferenças entre os indivíduos com e sem insônia, por exemplo, na memória de trabalho. OBJETIVO: Examinar as evidências sobre as diferenças entre adultos insones e normais no desempenho da memória de trabalho. MÉTODOS: A pesquisa foi realizada usando uma pesquisa avançada no ISI Web of Science e MEDLINE/PubMed com os termos "sleep", "insônia" e "memória de trabalho" como os principais descritores, que foram cruzados com as seguintes palavras-chave: "testes psicológicos", "neuropsicologia" e "performance". RESULTADOS: Um total de 132 artigos foram identificados na pesquisa realizada no PubMed e Web of Science; 20 duplicações foram excluídas. Após a triagem, 102 artigos foram excluídos, que não estavam relacionadas com o tema proposto. Assim, 10 artigos foram selecionados por critérios de elegibilidade e de exclusão, e incluídos na revisão sistemática. CONCLUSÃO: As descobertas relatadas em nosso estudo sugerem que os deficits leves mas não permanentes de desempenho cognitivo podem ser mascarados por disparidades insignificantes em estudos que comparam indivíduos com insônia com pessoas com sono normal. Tal deficiência pode ser contornada pela análise de amostras maiores e mais bem caracterizadas, em conjunto com o controle metodológico otimizado de fatores que potencialmente podem incorrer em variações entre os participantes.

Rendimiento cognitivo y calidad de vida de adultos mayores asistentes a grupos de tercera edad / Cognitive performance and the quality of life in older adults participating in a group of seniors

Introducción: El envejecimiento genera cambios cognitivos irreversibles, que influyen en aspectos psicológicos, sociales, físicos y emocionales, y por ende, en la calidad de vida. Objetivo: Establecer diferencias entre el rendimiento cognitivo y la calidad de vida en adultos mayores que participan en un grupo de la tercera edad y adultos que no participan en estos programas. Materiales y métodos: Se aplicó una batería neuropsicológica y una escala de calidad de vida a 36 adultos mayores entre 60 y 75 años. La muestra se dividió en dos grupos, cada uno conformado por 18 personas. El grupo A hace referencia a participantes que asisten a grupos de la tercera edad y el grupo B a los que no asisten a dichos grupos. Resultados: Los adultos que participan en grupos de la tercera edad presentaron mejor rendimiento cognitivo que aquellos que no asisten (p = 0,02), mientras que en la escala de calidad de vida no hubo diferencias significativas entre los grupos. Conclusión: El rendimiento cognoscitivo fue diferente en los grupos, pero en ambos se apreció un rendimiento normal. La calidad de vida fue igual en los dos grupos. No se evidenció que los cambios cognitivos afecten la calidad de vida, aunque se resaltó la importancia de la inclusión social y las redes sociales como un factor que incide en el bienestar psicológico y emocional del individuo.

Introduction: Aging produces irreversible cognitive changes that affect psychological, social, physical and emotional aspects; and therefore the quality of life. Objective: Differentiate between cognitive performance and the quality of life in older adults participating in a group of seniors contrasting with a group that do not participate in thoses programs. Materials and methods: A neuropsychological battery and a quality of life scale was applied to 36 elderly between 60 and 75 years. The sample was divided into two groups, each made up of 18 people. Group A refers to participants attending the elderly groups and group B those who did not attend such groups. Results: 368 patients with ischemic stroke and 63 (17%) with AF (54% male), aged (77.6 ± 10.25 years), hypertens Adults who participate in groups of seniors had better cognitive performance than those who do not attend; while the scale of quality of life, none of the dimensions differ significantly between the two groups. Conclusion: While cognitive performance differed between the groups, both were at a normal performance, there is no evidence of impairment. The quality of life was maintained in both, it was not demonstrated that cognitive changes affecting the quality of life and the importance of social inclusion and social networks as a factor that affects the psychological and emotional well-being of the individual is highlighted.

Efeitos do treino com jogos de videogame na cognição de idosos: revisão sistemática / Effects of video game training on cognition in the elderly: systematic review

OBJETIVOS: realizar uma revisão sistemática da literatura sobre o efeito do treino com jogos de videogame na cognição de idosos. MÉTODOS: Busca nas bases de dados LILACS, SciELO, PsycINFO e PubMed, idiomas Inglês e Português. Utilizaram-se os descritores treino com jogos de videogame / video game training, adicionando aos seguintes: cognição / cognition, efeito cognitivo / cognitive effects, desempenho cognitivo / cognitive performance, plasticidade cognitiva / cognitive plasticity, testes cognitivos / cognitive tests. Foram incluídos estudos de intervenção cognitiva, artigos originais e disponíveis na íntegra, população alvo idosos (60 anos ou mais), publicados entre 2005 e 2015. A revisão ocorreu entre janeiro e julho de 2015. RESULTADOS: Dos 70 artigos encontrados inicialmente, 21 estudos atenderam aos critérios de seleção. Sete estudos (33%) verificaram melhoras significativas em velocidade de processamento, atenção sustentada, alerta, memória de trabalho visoespacial, flexibilidade cognitiva, memória visual imediata e tardia e coordenação viso-motora-espacial. Em relação à metodologia de treino dos estudos, 11 (52%) foram com treino de curta duração (uma a seis semanas) e tempo total entre menor tempo 4,5 horas e maior tempo 23,5 horas; e 10 (47%) com treino de longa duração (sete a 12 semanas) e tempo total de treino entre 12 e 36 horas. Os treinos de curta duração foram mais eficazes. CONCLUSÕES: A constatação do tempo total necessário de treino foi o achado principal desta revisão sistemática. Intervenção cognitiva com uso de jogos de vídeo game de curta duração, entre uma e seis semanas, e tempo total do programa de treino cognitivo entre 4,5 horas e 23,5 horas foi eficaz para idosos, sendo esta uma dose de tempo de intervenção cognitiva necessária e suficiente para a consolidação de sistemas e aquisição de um aprendizado no envelhecimento. Os efeitos cognitivos encontrados nos estudos sugerem que o cérebro idoso é capaz de adquirir, manter e enriquecer-se com novas aprendizagens.

AIMS: To perform a systematic review of the literature on the effect of video game training on cognition in the elderly. METHODS: The search was conducted using LILACS, SciELO, PsyINFO and PubMed databases in both English and Portuguese. The search term used were video game training, combined with the following: cognition, cognitive effects, cognitive performance, cognitive plasticity, cognitive tests. The inclusion criteria consisted of intervention studies on video game training, original articles in English or Portuguese, fulltext availability, and target population older people. Studies that failed to meet these criteria were excluded. Articles from 2005 to 2015 were collected, and the review was performed between January 2015 and July 2015. RESULTS: Seventy articles were found, but only twenty-one met the selection criteria. Of the 21 articles included in the study, only 7 studies (33%) revealed statistically significant improvement in speed of processing, sustained attention and alert, working visuospatial memory, cognitive flexibility, immediate and delayed visual memory, visual-motor coordination and visuospatial ability between the research groups (p<0.05). Other results were found in relation to the methodology of the studies. Of the 21 studies, 11 studies (52%) were performed with training of short duration (1-6 weeks) and total time of training ranging between 4.5 and 23.5 hours. Ten studies (47%) were performed with training of long duration (7-12 weeks) total time of training between 12 and 36 hours. The short duration training showed better performance. CONCLUSIONS: The total time required for training was the main finding of this systematic review. Cognitive intervention using short duration training (between one and six weeks) with video games in a total time between 4.5 and 23.5 hours is effective in elderly participants. This length time between the minimum and maximum time of cognitive intervention is necessary and sufficient for the consolidation of systems and acquisition of a learning in aging. The cognitive effects observed in the studies suggest that the aging brain is able to acquire, maintain and even enrich new learnings.

Desempenho cognitivo em pacientes com Transtorno de Personalidade Borderline com e sem histórico de tentativas de suicídio / Cognitive performance in patients with Borderline Personality Disorder with and without history of suicide attempts / Desarrollo cognitivo en pacientes con Trastorno de Personalidad Borderline con y sin histórico de tentativas de suicidio

Este estudo teve como objetivo avaliar o desempenho cognitivo, a impulsividade e a ideação suicida em 82 (M=31,80; DP=0,96) pacientes internados em uma clínica psiquiátrica de Porto Alegre, RS. Os pacientes foram divididos em dois grupos, sem (G1=33) e com histórico de tentativa de suicídio (G2=49). Foram aplicados os seguintes instrumentos: a Escala Wechsler de Inteligência para adultos (WAIS III), a Escala Barratt de Impulsividade (BIS), a Escala Beck de Suicídio (BSI), a Escala FAST e um questionário sobre dados sociodemográficos. Os resultados não apontam diferenças significativas entre os dois grupos no que se refere ao QI total e às funções executivas. Os níveis de impulsividade, assim como a ideação suicida mostraram-se mais elevados no grupo de pacientes com histórico de tentativas de suicídio, especialmente nos pacientes com idade inferior a 30 anos. Entre as comorbidades, verificou-se que a dependência química foi a de maior prevalência, seguida do transtorno de humor bipolar e depressão. Os resultados sugerem similaridades entre os grupos de pacientes com e sem histórico de suicídio, representando um alerta e um desafio. Evidências acerca da impulsividade corroboram dados de estudos anteriores, assim como o que se refere às comorbidades identificadas.

The objective of this study was to assess cognitive performance, impulsivity, and suicidal ideation in 82 (M=31.80; SD=0.96) inpatients of a psychiatric clinic in Porto Alegre, RS. Patients were divided into two groups without (G1=33) and with a history of suicide attempt (G2=49). We administered the following instruments: the Wechsler Adult Intelligence Scale (WAIS III), the Barratt Impulsiveness Scale (BIS), the Beck Scale for Suicide Ideation (BSI), the FAST Scale, and a questionnaire on sociodemographic data. The results showed no significant differences between the two groups with respect to total IQ and executive functions specifically. The levels of impulsivity, as well as suicidal ideation, were higher in patients with a history of suicide attempts, especially in patients younger than 30 years. Considering the comorbidities, we found that chemical dependency showed the highest prevalence, followed by bipolar disorder and depression. The results demonstrated that the similarities between the groups of patients with and without a history of suicide attempt constitute a warning and a challenge. Evidences toward impulsivity confirm previous studies, as well as what refers to comorbidities identified.

Este estudio tuve como objetivo evaluar el desarrollo cognitivo, la impulsividad y la ideación suicida en 82 (M=31,80; DP=0,96) pacientes internos en una clínica psiquiátrica de La ciudad de Porto Alegre, RS. Los pacientes fueran divididos en dos grupos, sin (G1 =33) y con histórico de tentativa de suicidio (G2=49). Han sido aplicados los siguientes instrumentos: la Escala Wechsler de Inteligencia para adultos (WAIS III), la Escala Barratt de Impulsividad (BIS), la Escala Beck de Suicidio (BSI), la Escala FAST y un cuestionario sobre datos socio demográficos. Los resultados no muestran diferencias significativas entre los dos grupos no que se refiere al QI total e las funciones executivas. Los niveles de impulsividad, así como la ideación suicida estaban más elevados en el grupo de pacientes con histórico de tentativas de suicidio, especialmente en los pacientes con edad inferior a 30 años. Entre las comorbilidades, si ha verificado que la dependencia química ha sido la de mayor prevalencia, seguida del trastorno de humor bipolar y depresión. Los resultados sugieren similitudes entre los grupos de pacientes con y sin histórico de suicidio lo que representa un alerta y un desafío. Evidencias acerca de la impulsividad corroboran datos de estudios anteriores, así como lo que se refiere a las comorbilidades identificadas.

Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease / Polimorfismo do codon 129 do gene da proteina prionica nao e fator de risco para doenca de Alzheimer

Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD). Objective To describe the association between codon 129 polymorphisms and AD. Methods We investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated. Results Codon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups. Conclusion Codon 129 polymorphism is not a risk factor for AD in Brazilian patients.

Polimorfismo do códon 129 do gene da proteína priônica não é fator de risco para doença de Alzheimer A interação entre proteína priônica e oligômeros b-amiloide foi demonstrada recentemente. Homozigose no códon 129 do gene da proteína priônica (PRNP) é fator de risco para doença de Creutzfeldt-Jakob. Este polimorfismo foi estudado como possível fator de risco para doença de Alzheimer (DA). Objetivo Estudar uma possível associação entre o polimorfismo do códon 129 e DA. Métodos Foram investigados 99 pacientes com DA e 111 controles em relação ao polimorfismo do códon 129 e sua associação com desempenho cognitivo. Foram pesquisados outros polimorfismos do PRNP e efeito aditivo do gene da apolipoproteína E (ApoE). Resultados Distribuição no códon 129: 45,5% metionina (MM), 42,2% metionina valina (MV), 12,1% valina (VV) nos pacientes com DA; e 39,6% MM, 50,5% MV, 9,9% VV, nos controles (p >0.05). Não houve diferença no desempenho cognitivo em relação ao códon 129. Estratificação pelo genótipo do ApoE não mostrou diferença entre grupos. Conclusão Polimorfismo do códon 129 não é fator de risco para DA em pacientes brasileiros.