ABSTRACT
Objective: To observe the effect of Yaotongning Capsules combined with Imrecoxib Tablets in the treatment of ankylosing spondylitis with cold-dampness and blood-stasis syndrome. Methods: A total of 120 cases with ankylosing spondylitis were randomly divided into two groups: treatment group and control group, with 60 patients in each group. The control group was given Imrecoxib Tablets, and the treatment group was given Imrecoxib Tablets and Yaotongning Capsules. The levels of ESR, CRP, and the scores of BASDAI, BASFI, TCM syndrome were compared before and after treatment, the treatment effect of two groups were evaluated. Results: There was no significant difference in the levels of ESR, CRP and the scores of BASDAI, BASFI, TCM syndrome between two groups before treatment. After treatment, the levels of ESR, CRP and the scores of BASDAI, BASFI, TCM syndrome of the two groups were decreased (P < 0.05), and all the indexes in treatment group were lower than those in control group (P < 0.05), the total effective rate in treatment group (86.67%) was better than that in control group (65.00%) (P < 0.01). Conclusion: Yaotongning Capsules can effectively improve TCM syndrome and functional activity indexes, reduce inflammatory indexes and disease activity, has definite clinical effect on ankylosing spondylitis.
ABSTRACT
Objective: To evaluate the efficacy and safety of Yaotongning Capsules in the treatment of lumbar disc herniation (cold dampness and blood stasis syndrome). Methods: This research was carried out using stratified random method, blind, positive drug controlled, and multi-center clinical. And the random number was generated by SAS9.1.3 into two experimental groups (4 grains, 120 cases and 6 grains, 120 cases), and control group (120 cases). The experimental group was treated with Yaotongning Capsules for 4 weeks, and the control group was treated with Yaobitong Capsules for 4 weeks. At 0 day, 2, and 4 weeks, the VAS score, Oswestry dysfunction index, and onset time of pain were evaluated, and the efficacy and safety of the treatment were evaluated. Results: After 4 weeks of treatment, the efficacy of ODI grade showed that the excellent rates of the experimental group (4 grains), control group, and experimental group (6 grains) were 85.83%, 73.95%, and 85%, the efficacy of the experimental group (4 grains) was better than other groups, and the adverse reaction was the least. However, in terms of pain relief and improvement in the ODI scale, the experimental group (6 grains) in 2 and 4 weeks after treatment of In VAS and ODI improvement experiment, the decreased value of experimental group (6 grains) > experimental group (4 grains) > control group. Conclusion: Yaotongning Capsules in the treatment of lumbar disc herniation (cold dampness and blood stasis syndrome) have obviously curative effect and good safety, and have the advantage of the rapid relief of pain and could improve the function of lumbar spine.
ABSTRACT
Objective: To observe the clinical efficacy and safety of Yaotongning Capsule in acute sciatica suffered form cold dampness and blood stasis. Methods: A randomized, double-blind, and placebo controlled trial was performed. One hundred and forty-four patients with sciatica, who were in accordance with the accepting criteria from October 2008 to May 2009, were randomly divided into two groups, 72 cases treated with Yaotongning Capsule in the treatment group and 72 cases treated with placebo in the control group. Patients took five capsules with warm boiled water added yellow rice wine orally half an hour before sleep. The treatment course lasted for 2 weeks. Results: After one course of the treatment, there were significant differences in the curative rate between treatment group and control group. Compared with the control group, the disease control rate in the treatment group was obvious (U=4.138, P < 0.001); So did the pain relief (U=6.330, P < 0.001). And the differences both had statistical significance. There were no remarkable adverse event and side effect in the both groups. Conclusion: Yaotongning Capsule for sciatica suffered form cold dampness and blood stasis has reliable efficacy, safety, and less incident of adverse effects.