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To evaluate the efficacy and safety of Compound Glycyrrhizin Injection(CGI) in improving liver damage in chronic hepatitis B(CHB). PubMed, Web of Science, SinoMed, CNKI, Wanfang and VIP databases were retrieved from their inception to February 10, 2020. The randomized controlled trial(RCT) of CGI in the treatment of CHB was included. Data were independently extracted by two authors, and the methodological quality was evaluated using the Cochrane bias risk assessment tool by other two authors. Statistical analysis was performed using RevMan 5.3 software. A total of 18 two-armed RCTs were included, involving 1 915 participants. The methodological quality of all studies included was generally low. In the comparison between CGI and diammonium glycyrrhizinate, the results showed that CGI was superior to the control group in improving the overall clinical effectiveness, but there was no statistical difference between the two groups in increasing ALT normalization rate, reducing ALT and AST level. In the comparison between CGI and diammonium glycyrrhizinate+other general hepatoprotective drugs, the results showed that CGI was superior to the control group in reducing AST level, while there was no statistical difference between the two groups in reducing ALT level and increasing overall clinical effectiveness. In the comparison between CGI+other commonly used drugs(including energy mixture, glutathione, vitamins, potassium magnesium aspartate) and diammonium glycyrrhizinate+other commonly used drugs, the results showed that CGI combined with other commonly used drugs was better than the control group in reducing ALT and AST level and improving the clinical total effective rate, and there was no statistical difference between the two groups in increasing the rate of ALT normalization. In the comparison between CGI+other commonly used drugs and other commonly used drugs, the results showed that CGI combined with other commonly used drugs was superior to the control group in reducing ALT and AST level and improving the overall clinical effectiveness. In the comparison between CGI+vitamins and diammonium glycyrrhizinate+potassium magnesium aspartate+vitamins, the results showed no statistical difference between the two groups in reducing AST level. A small number of studies included reported that CGI caused mild adverse reactions when used alone or in combination with other drugs. Based on the results, CGI has a certain effect in improving CHB liver damage, but the evidence is not enough to prove that CGI would cause serious adverse events. In the future, more well-designed and strictly-enforced RCT with an adequate sample size are needed to further evaluate the effect CGI in alleviating CHB liver damage.
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Humans , Drugs, Chinese Herbal/adverse effects , Glycyrrhizic Acid , Hepatitis B, Chronic/drug therapyABSTRACT
Objective:To explore the clinical effect of compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel in the treatment of facial hormone-dependent dermatitis. Methods:Totally 108 patients with facial hormone-dependent dermatitis were selected randomly and divided into the control group(n = 54) and the treatment group(n =54). The control group was treated with desloratadine and 0.1% tacrolimus ointment;and the treatment group was treated with compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel additionally on the basis of control group. The clinical efficacy of the two groups was evaluated,and the improvement of symptoms and objective signs before and after the treatment was compared. The adverse reactions were recorded as well. Results:The total effective rate of the treatment group after one-month and two-month treatment was 75.93% and 90.74%, respectively, which were both higher than those of the control group(P < 0.05). The scores of symptoms and objective signs and the total scores of disease of the treatment group after one-month and two-month treatment and two-month follow-up were all lower than those of the control group, and the differences were statistically significant(P <0.05). The disappearance time of objective signs and the incidence of facial adverse reactions were both lower than those of the control group,and the differences were statistically significant(P < 0.05),however, the incidence of dry mouth in the treatment group was higher than that in the control group(P < 0.05). Conclusion:Compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel has better clinical effect for the therapy of facial hormone-dependent dermatitis,which can improve the symptoms significantly with high application security.
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Objective To evaluate the application of multiattribute utility theory(MAUT) in pharmacoeco-nomic evaluation of anti - inflammatory and hepatoprotective therapy for chronic hepatitis B ( CHB). Methods During year 2014 - 2016,214 patients with mild to moderate CHB were selected. The patients were divided into three groups: A,B and C according to the therapeutic regimen,and they were given compound glycyrrhizin,tiopronin and polyene phosphatidylcholine to prevent inflammation and protect liver. MAUT model was constructed,the evaluation factors were determined and appropriate weight was given to each element parameter,the specific utility values for each factor were calculated,and by calculating the total utility value of final results quantitatively demonstrated the three regimens in the treatment of chronic hepatitis B. Results The total effective rates of A,B,C three groups were 78. 38％ ,69. 44％ ,79. 41％ ,respectively,the difference was statistically significant( χ2 = 5. 559,P < 0. 05). The incidence rates of adverse reaction of A,B,C three groups were 16. 22％ ,8. 33％ ,5. 88％ ,respectively. As to direct cost,group B(1430. 45 yuan) was better than group C(1494. 04 yuan) and group A (1515. 92 yuan). The hospital days of A,B,C three groups were (11. 3 ± 4. 8) d,(10. 9 ± 10. 6) d,(12. 5 ± 6. 4) d,respectively. The results of MAUT comprehensive evaluation showed that the total score value in polyene phosphatidylcholine group was the highest,and was the optimal treatment in the study. Conclusion Application of MAUT in the study of pharmacoeco-nomics is comprehensive,intuitive and flexible.
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Objective To observe the clinical effect of compound glycyrrhizin in the treatment of alcoholic fatty liver disease(AFLD).Methods 68 AFLD patients according to the different treatment methods were divided into two groups.34 cases in the control group received conventional therapy ,34 cases in the observation group were given compound glycyrrhizin based on the conventional treatment .The clinical effect of the two groups was compared . Results The total effective rate of the observation group was 91.18%,which was higher than 64.71% of the control group,the difference was statistically significant (χ2 =6.928,P <0.05).The TBIL,GGT,AST,ALT of the observation group were (6.39 ±1.15)μmol/L,(157.79 ±17.39)U/L,(37.49 ±2.61)U/L,(24.45 ±2.16)U/L,respectively, which of the control group were (26.14 ±2.79)μmol/L,(417.59 ±45.89)U/L,(97.28 ±11.39)U/L,(54.33 ± 4.05) U/L,respectively,the differences between the two groups after treatment were statistically significant ( t =41.392,33.482,32.361,41.171,all P <0.05).The incidence rate of adverse reactions of the observation group was 5.88%,which was lower than 26.47% of the control group (χ2 =4.250,P <0.05).Conclusion Compared with conventional treatment,compound glycyrrhizin in the treatment of AFLD can effectively improve the patients 'TBIL, GGT,AST,ALT index,improve the clinical efficacy.
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Objective To evaluate the effect of compound glycyrrhizin on the prevention and cure of cytarabine syndromes. Methods A total of 130 patients with hematological malignancies treated by moderate or high dose of cytarabine in the 303th Hospital of PLA from July 2010 to July 2016 were included. Patients were randomly divided into the control group and the experiment group by using random number table method, and each group had 65 patients. In the control group, patients were treated with cytarabine alone. In the experiment group, patients were treated with cytarabine plus compound glycyrrhizin. Skin rash and fever in patients of the two groups were also recorded. Results of blood routine tests, liver and kidney function tests were monitored during the treatment. Results Sixty-one patients in the experiment group and 63 patients in the control group were enrolled finally. In experiment group and control group, the differences in the incidence of cytarabine syndromes [8.2 % (5/61) vs. 41.3 % (26/63), χ2＝ 18.1, P < 0.001], skin rash [1.6 % (1/61) vs. 12.7 % (8/63), χ2＝16.3, P <0.001], and fever [6.6 % (4/61) vs. 36.5 % (23/63), χ2＝5.63, P <0.017] were statistically significant. There was no significant difference of the incidence of liver injury and minimum blood cell count between the two groups (P＞ 0.05). Conclusion Compound glycyrrhizin can effectively reduce the incidence of cytarabine syndromes, but the larger size and multiple center studies are needed to further verify the effect.
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Objective To evaluate the clinical efficacy of compound glycyrrhizin injection in the treatment of melasma.Methods A total of 30 melasma patients with blood vessel scores of ++ or +++ and melanin scores of ++ or +++,which were evaluated by dermoscopy and reflectance confocal microscopy (RCM) respectively,were collected from the Department of Dermatology of Hangzhou Third Hospital between May 2015 and July 2016.All the patients were randomly divided into 2 groups by drawing lots:treatment group treated with intravenous drips of compound glycyrrhizin injection at a dose of 40 ml once every three days for 8 sessions,oral vitamin C tablets at a dose of 0.2 g thrice a day,and oral vitamin E tablets at a dose of 0.1 g once a day,and control group treated with oral vitamin C and vitamin E tablets at the same dose as the treatment group.Three months after starting the treatment,the therapeutic effect was evaluated using melasma area and severity index (MASI).Meanwhile,RCM,dermoscopy and VISIA skin detector were used to detect skin lesions,and the melanin score,blood vessel score and brown spot and erythema indices were calculated.Results For the treatment group,the melanin score and blood vessel score were both significantly decreased at 3 months after starting the treatment compared with those before the treatment (Z =2.773,3.135,P =0.006,0.002,respectively),so were the brown spot index (38.3 ± 3.1 vs.43.9 ± 5.8,Z =3.091,P =0.002)and erythema index (26.5 ± 5.6 vs.33.3 ± 7.7,t =2.752,P =0.010).For the control group,the melanin score significantly decreased at 3 months after starting the treatment compared with those before the treatment (P =0.023),while no significant differences were observed in the blood vessel score or VISIA indices (P ＞ 0.05).Three months after starting the treatment,9 cases showed marked improvement,and 6 showed improvement in the treatment group;3 cases showed marked improvement,11 improvement,and 1 showed no improvement in the control group.The therapeutic effect in the treatment group was significantly superior to that in the control group (Z =2.276,P =0.029).Conclusion Compound glycyrrhizin injection is effective for the treatment of melasma,and RCM,dermoscopy and VISIA skin detector can be used to assist efficacy evaluation in melasma.
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Objective To investigate the effect of compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria and its effect on plasma histamine.Methods 100 patients with chronic urticaria were selected as study objects,and they were divided into the control group(50 cases) and observation group(50 cases) according to the random number table method.The control group was treated with fexofenadine hydrochloride,while the observation group was treated with compound glycyrrhizin on the basis of the control group.The clinical effect and plasma histamine level were compared between the two groups.Results The effective rate of the observation group was 96.0%,which was significantly higher than 84.0% of the control group(χ2=7.951,P<0.05).After treatment,the plasma histamine content of the observation group was (2.38±0.26)ng/mL,which was lower than (3.10±0.29)ng/mL of the control group,and the difference between the two groups was statistically significant(t=6.084,P<0.05).Conclusion The compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria can reduce the symptoms of the patients,reduce the number and size of the patients and effectively control the clinical symptoms of the patients.And it can effectively reduce the level of plasma histamine in patients with good clinical effect and application value,it is worth to be promoted in clinical.
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Objective To investigate the clinical efficacy and safety of triclosan in combination with compound glycyrrhizin in the treatment of chronic urticaria. Methods A total of 100 patients with chronic urticaria who were enrolled in our hospital from December 2014 to December 2015 were divided into control group and observation group by random number table method,with 50 cases in each group. The control group was given desloratadine alone, and the observation group was treated with on the basis of the addition of compound glycyrrhizin tablets adjuvant therapy.compare the two groups of patients withThe short-term efficacy,the scores of 7 days urticaria activity,the laboratory indicators and the rate of follow-up recurrence were compared before and after treatment in two groups. Results The total effective rate (96.00％) of the observation group was significantly higher than that of the control group (76.00％) (P <0.05). After the treatment of 7days, the urticaria and itching score in the observation group [(0.79 ± 0.20), (0.65 ± 0.10)] were significantly lower than the control group [(1.54 ± 0.29), (1.29 ± 0.42)] (P<0.05). The levels of IL-4, IFN-γ and IgE in the observation group [(28.16 ± 4.10) pg / mL, (11.95 ± 3.05) pg / mL, (55.21 ± 11.37 g / L) were significantly higher than those in the control group[(35.40 ± 7.92) pg/mL,(7.23 ± 1.89) pg/mL, (73.75 ± 15.09) g/L] (P<0.05). The recurrence rate (10.00％, 18.00％) in the observation group was significantly lower than that in the control group (24.00％, 36.00％) (P<0.05).Conclusion The treatment of chronic urticaria with cisplatin combined with compound glycyrrhizin can alleviate the symptoms of skin lesions, improve the level of related laboratory indicators and help to avoid long-term recurrence.
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Objective To investigate the effect of liver detoxification soup combined with compound glycyrrhizin on hepatitis-related factors in patients with chronic hepatitis B.MethodsFrom April 2014 to August 2015, 86 patients with chronic hepatitis B were enrolled in this study.Random number table was divided into observation group and control group (43 cases).The control group was given routine glycyrrhizin and other conventional (ALT), serum total bilirubin (TBil), serum albumin transferase (ALT) and serum total bilirubin (TBil) were measured before and after treatment.(HA), laminin (LN), type Ⅳ collagen (Ⅳ-C) and type Ⅲ procollagen (PCⅢ) were used to analyze the effect of hepatic fibrosis, And observe adverse reactions.ResultsThe effective rate of the observation group was 93.02% higher than that of the control group (76.74%, P<0.05).After treatment, the patients were treated with chest discomfort, emotional depression, epigastric fullness, fatigue, ALT (35.28±1.35) U/L, HA (165.25±1.44) mg/L, and the treatment group (P<0.05).After treatment, the levels of TBil (30.34±1.59)μmol/L, Alb (48.32±1.33)g/L, and the level of serum was significantly higher than that of the control group (P<0.01).The incidence of adverse reactions was 11.63% and 6.98% in the two groups.ConclusionTraditional Chinese medicine hepatectomy decoction combined with compound glycyrrhizin can effectively treat chronic hepatitis B and improve the level of serum hepatitis-related factors, and the adverse reaction is light, it is worthy of clinical application.
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Objective: To explore psoriasis vulgaris efficacy of the narrow band UVB therapy combined with compound glycyrrhizin. Methods: The study made it clear diagnosis for patients admitted to our hospital 45 patients with psoriasis vulgaris were randomly divided into experimental group with 25 cases(narrow band UVB therapy combined with compound glycyrrhizin) and control group with 20 cases(only narrow-band UVB irradiation), in order to compare and analyze the treatment effect, the incidence of adverse reactions and symptoms before and after treatment PASI score recorded. Results: The difference was not statistically significant about PASI score of patients in the experimental group and the control group before treatment(t=0.153, P>0.05). But the difference of PASI score was statistically significant between two groups of patients after treatment(t=4.675, P<0.05). The effective rate of treatment in patients of the experimental group was 92%and 75%in the control group. The adverse symptoms in the experimental group and control group were 20% and 60% respectively. The differences were statistically significant (x2=47.908, P<0.05). Conclusion: Narrow band UVB combined with compound glycyrrhizin treatment of psoriasis with respect to only a narrow band ultraviolet therapy have significant therapeutic effect, and it can effectively reduce the incidence of adverse symptoms. It is worth popularizing in clinical.
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Objective:To observe the impact of compound glycyrrhizin combined with triamcinolone acetonide on clinical effects and immune function in the patients with oral lichen planus ( OLP) . Methods:Totally 100 patients with OLP were randomly divided into the control group (50 cases) and the study group (50 cases). The control group was locally injected with triamcinolone acetonide, and the study group was treated with compound glycyrrhizin tablets additionally. The treatment course was 4 weeks. Visual analogue scale ( VAS) and REU scoring system were used to assess pain and symptoms of OLP, the clinical effects and cellular immune function were compared, and the adverse reactions were recorded as well. Results:After the treatment, the VAS score and REU score respec-tively lower than those for the control group, and there were differents between the two groups (P<0. 05). The total effective rate was 84. 0% in the study group, which was higher than that in the control group (66. 0%) (P<0. 05). The percentage of CD3+ and CD4+ cells was increased, that of CD19+ cells and the ratio of CD4+/CD8+ were decreased, and there were significant differences be-tween the two groups (P<0. 05). The adverse reactions in both groups were mild. Conclusion:Compound glycyrrhizin combined with triamcinolone acetonide is effective for OLP and can improve the immune function in the patients.
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Objective To observe the effect of glycyrrhizin (CG) on the proliferation and the expressions of interleukin (IL)-2, IL-4 in human keratinocytes cell line HaCaT cells, and to investigate the therapeutic mechanism of CG in the pa?tients with psoriasis. Methods The HaCaT cells were divided into four groups:blank group (without CG), low concentration group (50μL CG/mL cell supernatant), medium concentration group (100μL CG/mL cell supernatant) and high concentra?tion group (200μL CG/mL cell supernatant). Methyl thiazolyl tetrazolium (MTT) assay was performed to evaluate the prolifer?ation of HaCaT cells that were treated with CG at different concentrations respectively for 24 hours. The contents of IL-2 and IL-4 in HaCaT cells were examined by enzyme linked immunosorbent assay (ELISA). Results Compared with the blank group, there were obviously inhibitory effects in the proliferation of HaCaT cells treated by low,medium and high concentra?tions of CG for 24 hours. There was no significant difference in IL-2 level between low concentration CG group and blank group (ng/L:234.51±17.98 vs 225.31±16.23, P>0.05). After 24 hours of intervention with CG of medium and high concen?trations, the expression levels of IL-2 was significantly lower in HaCaT cells than that in blank group and low concentration group. The IL-2 level was significantly lower in high concentration group than that in medium concentration group (ng/L:188.99±19.22 vs 208.49±18.40, P<0.05). At the same condition, the secretion of IL-4 in HaCaT cells was significantly up-regulated in high concentration group than that in other three groups (ng/L:45.67±10.29 vs 37.62±3.90, 39.68±6.08, 43.85± 10.26, P<0.05). Conclusion Glycyrrhizin may suppress the proliferation of human skin keratinocytes by regulating secre?tion of cytokines IL-2 and IL-4.
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OBJECTIVE:To observe therapeutic efficacy and safety of Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection in the treatment of erythrodermic psoriasis. METHODS:120 cases of erythrodermic psoriasis were randomly divided into observation group and control group,60 cases in each. Control group received Calcipotriol betamethasone ointment topical,2 times a day,for 6 weeks. Observation group was additionally given Compound glycyrrhizin injection 80 ml add-ed into 250 ml Glucose solution intravenously,once a day,on the basis of control group. PASI score,VAS score,DLQI score, Clinical efficacy and ADR of 2 groups were observed. RESULTS:Two groups of patients after treatment,PASI score,VAS score, lesion area and DLQI score were significantly decreased,the observation group decreased more significantly,the difference was sta-tistically significant (P0.05). CONCLUSIONS:Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection can effectively alleviate the clinical symptoms of psoriasis erythrodermic,improve their quality of life,has a definite curative effect and ADR.
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OBJECTIVE:To observe the clinical efficacy and safety of compound glycyrrhizin combined with acyclovir in the treatment of children with infectious mononucleosis. METHODS:90 children with infectious mononucleosis were randomly divid-ed into control group and research group. Control group was given Acyclovir injection 10 mg/(kg·d)adding into 150 ml 5% Glu-cose solution by intravenous infusion,twice a day. Research group was additionally given Compound glycyrrhizin injection 2-4 ml/kg,adding into 150 ml 5% Glucose solution by intravenous infusion,twice a day. The treatment course for both group was 2 weeks. Clinical efficacy,hospitalization time,improvement time of clinical symptoms,T lymphocyte subsets(CD3+,CD4+,CD8+ and CD4+/CD8+)before and after treatment and incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in research group was significantly higher than control group,hospitalization time and improvement time of clinical symptoms were significantly better than control group,the differences were statistically significant(P0.05). CONCLUSIONS:Compound glycyrrhizin combined with acyclovir has better efficacy than only acyclovir in the treatment of children with infectious mononucleosis,with similar safety.
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OBJECTIVE:To observe the effect of Compound glycyrrhizin on serum VEGF of patients with alopecia areata. METHODS:36 alopecia areata patients were selected as trial group and treated with Compound glycyrrhizin(50 mg/time,3 times/d) for 3 months. Double-antibody sandwich ELISA method was adopted to determine the content of VEGF in serum before and after treatment. 36 healthy volunteers were included in control group,and serum content of VEGF in control group was compared with trial group. RESULTS:Compared with control group,the serum content of VEGF was lower in trial group,with statistical signifi-cance(t=5.863,P0.05). CONCLUSIONS:Compound glycyrrhizin can cure alopecia areata through increasing serum level of VEGF.
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Objective To explore the clinical efficacy of Ebastine joint Compound Glycyrrhizin in treatment of acute and chronic urticarial, and its effect on serum IgE levels.Methods Eighty cases of a-cute and chronic urticaria patients were collected from January 2010 to June 2014 in our hospital for treat-ment.They were randomly divided into control group and observation group, 40 cases in each group, the patients in the control group oral ebastine 10mg 1 times /day, patients in the observation group were given Compound Glycyrrhizin on 75mg and oral ebastine 10mg, 1 times /d, acute urticaria patients were treated for one week of continuous treatment, patients with chronic urticaria were treated for 4 weeks in a row;IgE level was measured by ELISA.Results After treatment, effective rate of patients with acute urticaria was 94.44%in the observation group, the control group was 68.42%; patients with chronic urticaria observa-tion group was 95.45%, the control group was 71.43%, a significant difference ( P <0.05 ) between the observation group and control group.IgE levels in both groups after treatment were reduced compared with before treatment ( P <0.01), after treatment IgE levels of patients had higher degree of improvement in the observation group, differences were statistically significant ( P <0.05).Conclusions The clinical effica-cy of ebastine joint Compound Glycyrrhizin on treatment of acute and chronic urticaria are better than single ebastine, two drugs used in conjunction with synergistic effect by regulating the body's immune function, re-duce allergy strength, improve efficacy.
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Objective To investigate the effect of Glycyrrhizin combined with puerarin on serum Leptin and insulin resistance in non-alcoholic fatty liver disease(NAFLD) patients.Methods One hundred and twenty patients with NAFLD were randomized into 4 groups,which were control group,compound Glycyrrhizin group,puerarin group,combined group,and each group was 30 cases.Patients in control group were received the regular liver protecting therapy including vitamins,amino acids,glucurolactone,in compound Glycyrrhizin group were given 60 ml compound glycyrrhizin solution (iv),in puerarin group were given puerarin at dose of 400 mg by intravenous infusion,and in combined group were given both compound glycyrrhizin and puerarin combination.All treatment period was 4 weeks.The levels of serum serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total cholesterol (TC),triglyceride (TG),leptin (LP),fasting blood glucose (FBG) and insulin(INS) were measured,and the insulin resistance index(IRI) was calculated.The liver CT image of patients were performed by Germany Siemens dual source CT instrument.Results The levels of serum ALT,AST,TC,TG,LP and IRI in control group at before and after treatment were ((83.08 ± 115.68) U/L vs.(43.32 ±11.72) U/L,(52.12±15.62) U/Lvs.(36.08 ±7.28) U/L,(6.20±1.30) mmol/Lvs.(5.60 ±0.70) mmol/L,(2.70 ±0.50) mmol/L vs.(2.10 ±0.40) mmol/L,(14.63 ±3.26) μg/L vs.(7.61 ± 2.46) μg/L,(7.9 ± 1.8) vs.(7.0 ± 1.2)),and the difference were statistically significant (t =12.828,4.244,16.648,21.442,3.341,16.152 respectively,P ＜ 0.01).The levels of serum ALT,AST,TC,TG,LP and IRI in compound glycyrrhizin group after treatment were ((43.28 ± 11.06) U/L,(37.28 ± 7.22) U/L,(5.70± 0.80) mmol/L,(2.20 ± 0.50) mmol/L,(7.89 ± 2.26) μg/L,(7.1 ± 1.6) respectively,significant different from before treatment ((83.06 ± 14.38) U/L,(51.68 ± 15.48) U/L,(6.30 ± 1.50) mmol/L,(2.60 ± 0.40) mmol/L,(15.13 ± 3.87) μg/L,(7.8 ± 2.2) respectively,t =8.893,4.225,16.520,24.708,6.353,21.137 respectively,P ＜ 0.01).The levels of serum ALT,AST,TC,TG,LP and ISI in puerarin group after treatment were (44.26 ± 9.68) U/L,(36.86 ± 6.88) U/L,(5.60 ± 0.70) mmol/L,(2.26 ± 0.48) mmol/L,(6.89 ± 2.18) μg/L,(7.0 ± 1.8) respectively,significant different from that before treatment ((82.68±14.36) U/L,(50.06±15.23) U/L,(6.20±1.60) mmol/L,(2.70±0.52) mmol/L,(15.68 ±3.26)μg/L,(7.7 ±2.8) respectively,t =7.087,8.138,18.159,7.244,7.470,32.283 respectively,P ＜ 0.01).The levels of serum ALT,AST,TC,TG,LP and ISI in combined treatment group after treatment were (22.28 ± 9.38)U/L,(28.48 ± 9.06) U/L,(5.00 ± 0.60) mmol/L,(1.70 ± 0.40) mmol/L,(4.63 ± 2.36) μg/L,(6.20± 1.6) respectively,significantly different from that before treatment ((84.62 ± 14.88) U/L,(49.12 ± 16.56)U/L,(5.70 ± 1.60) mmol/L,(2.78 ± 0.50) mmol/L,(14.78 ± 3.68) μg/L,(7.6 ± 2.1),t =14.255,11.272,8.371,9.941,8.102,37.626,P ＜ 0.01).The levels of serum ALT,AST,TC,TG,LP and ISI of patient were no significant difference before treatment,but after treatment,these indexes in combined therapy group were the lowest among 4 groups (P ＜ 0.05).And there were no significant difference among control group,compound glycyrrhizin group,puerarin group (P ＞ 0.05).Conclusion Compound glycyrrhizin combined with puerarin is proved to be an effect treatment method for NAFLD through decreasing serum leptin,improving insulin resistance.
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Objective To investigate the clinical effect and safety of compound glycyrrhizin combined with bozhi glycopeptide in treatment of erythema nodosum.Methods Sixty-four patients with erythema nodosum were divided into treatment group (36 cases) and control group (28 cases) by random digits table method.The patients in treatment group were given compound glycyrrhizin 120 mg,intravenous drip,once a day;and bozhi glycopeptide 4 ml,intravenous drip,once a day.The patients in control group were given compound glycyrrhizin 120 mg,intravenous drip,once a day.The clinical efficacy and recurrence were compared between 2 groups.Results The total effective rate in treatment group was significantly higher than that in control group [86.1％ (31/36) vs.57.1％ (16/28)],there was statistical difference (P ＜ 0.05).Follow-up for 3 months,the rate of recurrence in treatment group was significantly lower than that in control group [16.1％(5/31) vs.8/16],there was statistical difference (P＜ 0.05).Conclusion Compound glycyrrhizin combined with bozhi glycopeptide can effectively control the erythema nodosum,and has no significant adverse reactions,reduces the rate of recurrence,and it is worthy of promotion and application.
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Objective To observe the effect and safety of the compound glycyrrhizin combined recombinant human epidermal growth factor in treatment of eczema. Methods 120 eczema patients were selected randomly divided into the treatment group (n=60) and the control group (n=60) ,the treatment group intravenously given compound glycyrrhizin once a day, 60ml combined recombinant human epidermal growth factor analgesic spray, three times a day. The control group were given intravenously compound glycyrrhizin,once a day ,60ml. Two groups of patients were continuous treatment after a month observation curative effect and adverse reaction. Results The effective rate in the treatment group(91. 67%) was higher than the control group(71.67%) ,there was significant difference(x2=6.43,P＜0.05). Compared with control group, VAS of the treatment group was significantly reduced, there is significant difference (P＜0.05). In the same group,within one month after treatment,before treatment and after treatment compared also has difference, there are significant difference (P＜0.05). The two groups had no serious adverse reactions. Conclusion Effect of compound glycyrrhizin combined recombinant human epidermal growth factor in treatment of eczema curative was distinct,which was worth extending.
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Objective To study the influence on T-lymphocyte subsets in herpes zoster with adjuvant treatment of compound glycyrrhizin.Methods 93 patients with herpes zoster were randomly divided into two groups:control group(46 cases,treated with antiviral drugs) and 1 treatment group(47 cases,treated with compound glycyrrhizin and antiviral drugs).The expression of T-lymphocyte subsets on the T cell surface in patients and control group were determined by flow cytometry.Results The expression of CD3,CD4,CD8,CD4/CD8 ratio was significantly different in the treatment group and control group.Conclusion Compound glycyrrhizic adjuvant therapy could not only shorten check blister,acetanilide,scar tissue and recovery time,reduce the sequela of neuralgia,but also affect the expression state of T lymphocyte subsets with herpes zoster,improve the cellular immune function with herpes zoster.