ABSTRACT
Objective To explore the clinical effect of dynamic enhancement combined with diffusion -weighted magnetic resonance imaging( MRI) in the diagnosis of benign and malignant breast lesions. Methods From January 2017 to January 2018,100 patients with breast lesions in Zhoushan Hospital were selected in the study. The patients received MR-DWI and DCE-MRI inspection,and the results were compared with the pathological verification results. Results The ADC value of benign breast lesions was (1. 65 ± 0. 24) × 10 -3 mm2/s. The ADC value of malignant breast lesions was (1. 17 ± 0. 17) × 10 -3 mm2/s,and there was statistically significant difference in ADC value between patients with benign and malignant breast lesions(t=5. 021,P<0. 05). The number of type Ⅰ,typeⅡ and type Ⅲ curve cases of 88 patients with benign lesions was 62 cases(70. 45％),18 cases(20. 45％) and 8 cases(9. 09％),respectively. The number of patients with type Ⅰ,type Ⅱ and type Ⅲ curve of malignant lesion was 3 cases(15. 00％),5 cases(25. 00％) and 12 cases(60. 00％),respectively. For dynamic enhancement type Ⅰand type Ⅲ curve in breast benign and malignant lesions,the difference was statistically significant(χ2 =8. 254,P<0. 05). The area under the curve of the joint diagnosis compared with the simple use of ADC and DEC-MRI,the difference was statistically significant(χ2 =6. 032,P<0. 05). The ADC compared with DEC-the area under the curve of MRI in the diagnosis had no obvious difference(χ2 =5. 221,P>5. 221). Conclusion The integrated use of DWI and DCE-MRI can lay the solid data for the diagnosis of breast malignant tumor,and effectively strengthen the diagnostic sensitivity and specificity,and make clinical intervention and clinical treatment easily.
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Objective To screen for serum protein differentially expressed between women whose fetuses had congenital heart defects(CHD) and women who had normal fetuses. Methods Serum samples were collected from pregnant women whose fetuses had CHD and those whose fe?tuses had no CHD,including a CHD group of 40 women and a control group of 10 women. The CHD group included 4 subgroups as follows:tetralo?gy of Fallot,ventricular septal defects,persistent truncus arteriosus,and a mixture of relatively rare types of CHD(n=10 each). Samples in the same group were pooled to obtain equal amounts of proteins ,and the iTRAQ proteomic approach was used to identify and quantify the proteins dif?ferentially expressed among these groups. Results We successfully identified 606 proteins,among which 47 showed at least a 1.5?fold difference between the CHD and control groups. Among the 47 proteins,23 and 24 were upregulated and downregulated,respectively. Conclusion Several proteins associated with CHD could be identified by using the iTRAQ proteomic approach ,and various proteins were involved in the pathogenesis of CHD in this study.
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ABSTRACT Purpose: Comparison of laser therapy (LT) outcomes in patients with retinopathy of prematurity (ROP) followed up in our clinic and referred from other centers. Methods: Medical records of 1,856 ROP patients were retrospectively evaluated, and a total of 128 patients who underwent LT were included in the study. The study population was divided into the following two groups: patients who were followed up and treated in our clinic (group 1, N=45) and patients who were referred to our clinic from other centers (group 2, N=83). Data regarding birth weight, sex, gestational age, postnatal treatment time, disease localization, and stage were analyzed and compared between the two groups. Treatment success was defined by anatomic success 6 months after treatment. Results: Patients in the referred group presented with a more advanced disease (p<0.01), a lower treatment success rate (p=0.01), and a longer time interval between diagnosis and LT (p=0.04). Conclusions: The treatment success rate of ROP was significantly lower in referred patients because of the potential delay in LT and more advanced disease at the time of treatment initiation.
RESUMO Objetivos: A comparação dos resultados da terapia a laser (LT) em pacientes com retinopatia da prematuridade (ROP) acompanhados em nossa clínica e encaminhados por outras clínicas. Método: Os arquivos de 1.856 pacientes com ROP foram analisados retrospectivamente e um total de 128 pacientes submetidos à LT foram incluídos no estudo. A população do estudo foi dividida em dois grupos; os pacientes que foram acompanhados e tratados em nossa clínica (grupo 1, n=45) e os pacientes que foram encaminhados à nossa clínica por outros centros (grupo 2, n=83). Os dados referentes a peso de nascimento, sexo, idade gestacional, tempo de tratamento pós-natal, localização e fase da doença foram analisados e comparados entre os grupos. O sucesso do tratamento foi definido pelo sucesso anatômico no sexto mês após o tratamento. Resultados: Pacientes no grupo de pacientes encaminhados apresentaram doença mais avançada (p<0,01), taxa de sucesso inferior (p=0,01) e maior intervalo de tempo entre o diagnóstico e tratamento a laser (p=0,04). Conclusões: A taxa de sucesso do tratamento da ROP é significativamente menor em pacientes encaminhados por causa de possível atraso da LT e do estágio mais avançado da doença observado.