ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH)is a severe syndrome characterised by fever,splenomegaly,cytopenia,hyperferritinemia,hypertriglyceridemia and hypofibrinogennemia.HLH includes primary and secondary HLH.Secondary HLH can be encountered in.association with a variety of underlying condtions.Infectious triggers are most commonly due to viral infections,especially EBV infection.This review mainly introduces clinical characteration of several viral infections associated HLH.
ABSTRACT
V infection group than in no infection group,while positive rate of other autoantibodies was not statistically different between the two groups.Conclusion Renal EBV infection may involve in the pathogenesis of LN by inducing the production of anti-Sm-Ab.
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Objective:To detect and analyze the Epstein-Barr virus LMPI gene XhoI-site mutation in plasma of patients with nasopharyngeal carcinoma(NPC)in Chongqing of China.Methods:DNA extraction and PCR amplification was used in plasma of 48 NPC patients and 40 control non-NPC cases from Chongqing of China.All the PCR production was digested by enzyme XhoI,then segregated in 8% PAGE.XhoI-site mutation was analyzed by sequencing and comparing with B95-8 cell.Results: The LMP1 was amplified and digested successfully from 48 of 48 NPC cases(100%)and from 38 of 40 non-NPC cases (95%),but none of LMPI XhoI-site mutation was found.Sequencing was performed on 4 LMPI genes from NPC cases and 5 LMP1 genes from non-NPC cases,they showed the presence of the XhoI-site.Conclusions:XhoI-site in EBV LMP1 gene N terminus has no mutation in plasma of NPC or non-NPC cases in Chongqing of China.The precise relationship of XhoI-site mutation and NPC pathogenesis need further investigation.