Effects of caffeine on central and peripheral fatigue following closed- and open-loop cycling exercises

We examined whether endurance performance and neuromuscular fatigue would be affected by caffeine ingestion during closed- and open-loop exercises. Nine cyclists performed a closed-loop (4,000-m cycling time trial) and an open-loop exercise (work rate fixed at mean power of the closed-loop trial) 60 min after ingesting caffeine (CAF, 5 mg/kg) or placebo (PLA, cellulose). Central and peripheral fatigue was quantified via pre- to post-exercise decrease in quadriceps voluntary activation and potentiated twitch force, respectively. Test sensitivity for detecting caffeine-induced improvements in exercise performance was calculated as the mean change in time divided by the error of measurement. Caffeine ingestion reduced the time of the closed-loop trial (PLA: 375.1±14.5 s vs CAF: 368.2±14.9 s, P=0.024) and increased exercise tolerance during the open-loop trial (PLA: 418.2±99.5 s vs CAF: 552.5±106.5 s, P=0.001), with similar calculated sensitivity indices (1.5, 90%CI: 0.7-2.9 vs 2.8, 90%CI: 1.9-5.1). The reduction in voluntary activation was more pronounced (P=0.019) in open- (-6.8±8.3%) than in closed-loop exercises (-1.9±4.4%), but there was no difference between open- and closed-loop exercises for the potentiated twitch force reduction (-25.6±12.8 vs -26.6±12.0%, P>0.05). Caffeine had no effect on central and peripheral fatigue development in either mode of exercise. In conclusion, caffeine improved endurance performance in both modes of exercise without influence on post-exercise central and peripheral fatigue, with the open-loop exercise imposing a greater challenge to central fatigue tolerance.

Acute melatonin administration enhances aerobic tolerance: an analysis of biochemical and hematological parameters

Aims: This study is aimed at testing the acute melatonin administration (oral; 6 mg) on aerobic tolerance at cycloergometer and analyzing the consequences on biochemical and hematological parameters. Methods: The maximal aerobic capacity intensity (iMAC) at cycloergometer of eleven male healthy men (24.18±3.92 years-old; 87.07±12.48 kg; 1.82±0.05 m; 26.18±3.63 kg/m2; and 16.28±5.77 % of fat) was individually determined and used to perform a time to exhaustion (tlim) trial of 30 minutes after melatonin or placebo administration. We observed 48-72h interval between tests, performed in a double-blind experiment design. In order to determine hematological and biochemical parameters we collected venous blood samples before and after tlim. Statistical significance was set at 5%. Results The intensity and the lactatemia corresponding to the maximal aerobic capacity were 120.88±18.78 W and 3.32±1.03 mmol.L-1, respectively. The tlim with placebo (33.94±15.26 min, confidence interval = 24.92 - 42.95) was significantly lower than the tlim with melatonin (41.94±17.22 min; CI = 31.76 - 52.12; p = 0.03; 19.06%; effect size = 0.49). All of the 21 analyzed blood physiological variables resulted in no significant variation after tlim when placebo was compared to melatonin, except for total sera cholesterol (lower after exercise with melatonin). Conclusion: Acute melatonin administration enhanced aerobic tolerance at iMAC in 19% at cycloergometer; however, the biochemical and hematological variables assessed were not significantly modulated.(AU)

Carbohydrate mouth rinse reduces rating of perceived exertion but does not affect performance and energy systems contribution during a high-intensity exercise

Aim: The study aimed to verify the effect of carbohydrate (CHO) mouth rinse on time to exhaustion, energy systems contribution and rating of perceived exertion (RPE) during a high-intensity exercise. Methods Fourteen men performed an incremental exercise test to determine their maximal oxygen uptake and peak power output (PPO) and two time-to-exhaustion tests at 110% of PPO. Participants rinsed their mouth with 25ml of 6.4% of CHO or placebo (PLA) solution immediately before the time-to-exhaustion test, using a crossover design. The contribution of the energy systems was calculated using the free software GEDAE-LaB®. Results: Time to exhaustion was similar between the conditions (CHO:174.3±42.8s; PLA:166.7±26.3s; p=0.33). In addition, there was no difference between the CHO and PLA condition for aerobic (CHO:135.1±41.2kJ and PLA:129.8±35.3kJ, p=0.34), anaerobic lactic (CHO:57.6±17.1kJ and PLA:53.4±15.1kJ, p=0.10), and anaerobic alactic (CHO:10.4±8.4kJ and PLA:13.2±9.2kJ, p=0.37) contribution. Consequently, total energy expenditure was similar between conditions (CHO:203.2±46.4kJ and PLA:196.5±45.2kJ, p=0.15). However, CHO mouth rinse reduced the RPE at the moment of exhaustion (CHO:18.2±1.0units and PLA:19.1±1.1units; p=0.02). Conclusion: CHO mouth rinse neither increased time to exhaustion nor altered energy systems contribution during a high-intensity exercise, but reduced the perceived effort at the exhaustion.(AU)

Impact of a Multi-Component Dietary Supplement on Blood Testosterone, Nitrate/Nitrite and Physical Performance in Resistance-Trained Men.

Both D-aspartic acid (DAA) and nitrate have received considerable attention in recent years. Vitamin D3 is also considered important for overall physical health and has been associated with elevated blood testosterone. The present study evaluated the impact of a DAA-nitrate-vitamin D3 containing dietary supplement on anaerobic exercise performance, blood testosterone and nitrate/nitrite in men. Methods: 24 resistance-trained men (mean age: 23 years) were assigned to ingest a DAA-nitrate-vitamin D3 supplement or a placebo for 28 days. Exercise performance (upper body muscle power, force, and endurance; Wingate cycle sprints), in addition to blood total and free testosterone and nitrate/nitrite was measured before and after 14 and 28 days of supplementation. Results: No increase in total or free testosterone was noted at either measurement time (p>0.05), with values remaining stable or decreasing slightly following intake of the supplement. Nitrate/nitrite was increased significantly following intake of the supplement (p<0.05), from 19.1±2.1 µmol∙L-1 (pre) to 70.0±12.4 µmol∙L-1 at 14 days and 68.6±7.7 µmol∙L-1 at 28 days. Despite this increase in nitrate/nitrite, no performance variable was impacted in a statistically significant manner by supplementation (p>0.05). However, the cumulative number of repetitions performed during a five-set bench press challenge was 11.3% higher after 28 days of supplementation, as compared to 3.6% higher for placebo. Conclusion: Twenty-eight days of treatment with a DAA-nitrate-vitamin D3 supplement increases blood nitrate/nitrite and can moderately improve repetitive bench press performance. However, this supplement does not result in an increase in total or free testosterone or any other performance measure.

Carbohydrate mouth rinse does not improve repeated sprint performance / Enxágue bucal com carboidrato não melhora o desempenho em sprints repetidos

The objective of this study was to evaluate the effect of a carbohydrate mouth rinse on the repeated sprint ability (RSA) of young soccer players. Nine youth soccer players (15.0 ± 1.5 years; 60.7 ± 4.84 kg; 1.72 ± 0.05 m; 20.5 ± 1.25 kg/m²) were selected. The athletes were submitted to an RSA test consisting of six sprints of 40 m (going/ return = 20 m + 20 m), separated by 20 s of passive recovery, under three experimental conditions: carbohydrate mouth rinse (CHO) or placebo (PLA) and control (CON). The mouth rinses containing CHO or PLA were administered 5 min and immediately before the beginning of the test in doses of 100 mL. The best sprint time (RSAbest), mean sprint time (RSAmean), and drop-off in sprint performance (fatigue index) were determined for the different treatments. One-way ANOVA for repeated measures did not identify significant differences (P > 0.05) in RSAbest (CHO = 7.30 ± 0.31 s; PLA = 7.30 ± 0.30 s; CON = 7.26 ± 0.16 s), RSAmean (CHO = 7.71 ± 0.30 s; PLA = 7.71 ± 0.25 s; CON = 7.66 ± 0.24 s), or fatigue index (CHO = 5.58 ± 2.16%; PLA = 5.77 ± 3.04%; CON = 5.55 ± 3.72%). The results suggest that a carbohydrate mouth rinse does not improve the repeated sprint performance of young soccer players.

O objetivo deste trabalho foi analisar os efeitos do enxágue bucal com carboidrato sobre o desempenho, durante sprints repetidos (RSA), de jovens jogadores de futebol. Nove atletas de futebol da categoria infantil (15,0 ± 1,5 anos; 60,7 ± 4,84 kg; 1,72 ± 0,05 m; 20,5 ± 1,25 kg/m²) foram submetidos ao teste de RSA. O teste foi composto por seis sprints de 40 m (ida/volta = 20 m + 20 m), separados por 20 s de recuperação passiva com três condições experimentais: enxágue bucal com carboidrato (CHO) ou placebo (PLA) e controle (CON). O enxágue bucal com CHO ou PLA foi conduzido 5 min antes e imediatamente antes do início dos testes em doses de 100 mL. O tempo do melhor sprint (RSAbest), a média de tempo dos sprints (RSAmean) e o índice de fadiga (IF) foram determinados nas diferentes condições experimentais. ANOVA one-way para medidas repetidas não identificou diferenças significantes (P > 0,05) para RSAbest (CHO = 7,30 ± 0,31 s; PLA = 7,30 ± 0,30 s; CON = 7,26 ± 0,16 s), RSAmean (CHO = 7,71 ± 0,30 s; PLA = 7,71 ± 0,25 s; CON = 7,66 ± 0,24 s) e IF (CHO = 5,58 ± 2,16%; PLA = 5,77 ± 3,04%; CON = 5,55 ± 3,72%). Os resultados sugerem que o enxágue bucal com CHO não parece capaz de melhorar o desempenho, sobre sprints repetidos, de jovens jogadores de futebol.

Beta 2 agonistas en deportistas. ¿Una ayuda ergogénica? / Beta 2 agonists in athletes. An ergogenic aid?

El asma es una condición crónica de las vías aéreas con hiperreactividad bronquial y broncoconstricción. El ejercicio puede desencadenar los síntomas asmáticos, lo que se conoce como broncoespasmo inducido por el ejercicio (BIE). El asma es común en atletas olímpicos, por lo cual los deportistas utilizan los medicamentos β2 agonistas para prevenir y tratar los episodios de asma. Estos fármacos se suministran preferiblemente por inhalación. En el deporte, los β2 agonistas están restringidos por la regulación antidopaje, con base en que estos medicamentos tienen el potencial de mejorar el rendimiento físico, lo que puede resultar en una ventaja competitiva. Los β2 agonistas están prohibidos por la WADA (World Anti-doping Agency), con excepción del salbutamol (con suministro máximo permitido de 1.600 µg en 24 horas) y el salmeterol inhalado. Estos fármacos, administrados por vía oral, pueden tener efectos ergogénicos en los deportistas. Se ha documentado que administrado por esta vía el salbutamol puede mejorar el rendimiento en disciplinas de resistencia, aumentar la fuerza muscular y mejorar la potencia anaeróbica. Sin embargo, según la evidencia científica, los β2 agonistas inhalados no tienen un efecto relevante de aumento en el rendimiento en deportistas no asmáticos.

Asthma is a chronic disorder of the airways with bronchial hyperresponsiveness and bronchoconstriction. Exercise can trigger asthma symptoms; this condition is known as exerciseinduced bronchospasm (EIB). Asthma is common in Olympic athletes who therefore use β2 agonists to prevent and treat its episodes. These drugs are preferably supplied by inhalation. In sports, the use of β2 agonists is restricted by anti-doping regulation, arguing that these drugs have the potential to improve physical performance, which can result in a competitive advantage. β2 agonists are prohibited by the WADA (World Anti-Doping Agency), except salbutamol (maximum dose: 1.600 µg over 24 hours) and salmeterol. Oral administration of salbutamol can induce ergogenic effects in athletes. It has been documented that when given orally β2 agonists can improve performance in endurance disciplines, increase muscle strength and improve anaerobic power. However, according to scientific evidence, inhaled β2 agonists do not have a relevant performance-enhancing effect in nonasthmatic athletes.

A estimulação transcraniana por corrente contínua como recurso ergogênico: uma nova perspectiva no meio esportivo / Transcranial direct current stimulation as an ergogenic aid: a new perspective in sport

Nas duas últimas décadas tem-se verificado um considerável aumento no interesse de um grande número de pesquisadores em investigar o potencial de diferentes recursos ergogênicos que possam contribuir na melhoria do desempenho físico de atletas de diferentes modalidades. Grande parte dos estudos tem focado os mecanismos subjacentes ao desenvolvimento da fadiga, pelo fato de que este fenômeno complexo é considerado um fator limitante do desempenho esportivo. Sendo assim, recursos ergogênicos que são eficientes em protelar o desenvolvimento da fadiga podem melhorar o desempenho esportivo. Apesar de haver muitas discussões sobre a fadiga, sua causa exata ainda é um assunto controverso. Apesar disso, tem sido sugerido que mecanismos corticais podem estar envolvidos e que estudos sobre a modulação de regiões cerebrais específicas podem trazer respostas valiosas para entender melhor este fenômeno. Atualmente, a estimulação transcraniana por corrente contínua (ETCC) vem sendo utilizada como uma ferramenta não invasiva capaz de modular a excitabilidade de regiões específicas do córtex cerebral. Dados preliminares têm demonstrado que a ETCC anódica é capaz de aumentar a excitabilidade do córtex motor por até uma hora após sua aplicação, e também aumentar o tempo até em exercício isométrico até à exaustão. Estes dados sugerem ser provável que a ETCC possa ser utilizada como uma ferramenta em pesquisas sobre mecanismos envolvidos no desenvolvimento da fadiga e, talvez, como um possível recurso ergogênico para atletas.

The last two decades has followed an increase in interest from a large number of researchers interested in investigating the ergogenic potential of different resources that might assist in improving the physical performance of athletes in different sports. Most studies have focused on the mechanisms underlying the development of fatigue as this complex phenomenon is a limiting factor in sports performance. Thus, ergogenic resources that are effective in delaying the development of fatigue may improve athletic performance. Despite many discussions about fatigue, its exact cause is still a controversial subject. However, it has been suggested that cortical mechanisms may be involved and studies that have tried to modulate specific brain regions can provide valuable answers to better understand this phenomenon. Currently, (tDCS) has been used as a noninvasive tool that can modulate the excitability of specific regions of the cerebral cortex. Preliminary data have shown that tDCS anode is able to increase the excitability of motor cortex for up to one hour after its application and also increase the time until exhaustion in isometric exercise. These data suggest that tDCS can probably be used as a tool in research on mechanisms involved in the development of fatigue and perhaps as a potential ergogenic aid for athletes..

Enxágue bucal com carboidrato: recurso ergogênico capaz de otimizar o desempenho físico / Carbohydrate mouth rinse: an ergogenic aid able of optimizing the performance

Alguns estudos têm demonstrado que a simples presença de carboidrato na boca humana pode favorecer a ativação de algumas regiões cerebrais específicas com impacto positivo para a melhoria do desempenho físico. Assim, recentemente, a estratégia de enxágue bucal com carboidrato tem sido adotada com sucesso em exercícios físicos intensos (>70%VO2max) com duração de, aproximadamente, 60 min. Nesse sentido, o propósito deste estudo foi discutir, com base nas informações disponíveis na literatura, a eficácia ou não da estratégia de enxágue bucal com carboidrato para a melhoria do desempenho físico, bem como os possíveis mecanismos envolvidos. Os resultados produzidos, embora ainda preliminares, são bastante promissores, o que nos leva a acreditar que o enxágue bucal com carboidrato possa ser uma estratégia bastante interessante, sobretudo, pela fácil aplicabilidade, baixo custo e boa eficácia para a melhoria do desempenho físico em esforços físicos intensos e prolongados.

Studies have shown that the mere presence of carbohydrate in the human mouth promotes the activation of some specific brain regions, with a positive impact on physical performance. Thus, the strategy of carbohydrate mouth rinse has been recently adopted with success in strenuous exercise (> 70% VO2max) lasting approximately 60 min. In this respect, the objective of this study was to discuss, based on literature data, the efficacy of this strategy to improve physical performance, as well as the possible mechanisms involved. The results produced, although still preliminary, are promising and led us to believe that carbohydrate mouth rinse is an interesting strategy, especially because of its easy application, low cost and good efficacy in improving physical performance during intense and prolonged physical exercise.

Suplementação de creatina e treinamento de força: alterações na resultante de força máxima dinâmica e variáveis antropométricas em universitários submetidos a oito semanas de treinamento de força (hipertrofia) / Creatine supplementation and strength training: alterations in the resultant of dynamic maximum strength and anthropometric variables in college students submitted to 8 weeks of strength training (hypertrophy)

OBJETIVO: Verificar as alterações promovidas pela suplementação de creatina nas variáveis antropométricas e da resultante de força máxima dinâmica (RFMD) em universitários submetidos a oito semanas de treinamento de força. METODOLOGIA: Participaram deste estudo, 18 universitários do sexo masculino, com idade entre 19 e 25 anos. Antes do treinamento foram determinadas a estatura (cm), a massa corporal (kg) e testes de ação muscular voluntária máxima dinâmica (1AMVMD), os sujeitos foram assinalados a um dos dois grupos, A (creatina) e B (placebo), foi adotado o protocolo duplo-cego. Após oito semanas de treinamento de força, repetiu-se a bateria de testes do pré-treinamento. RESULTADOS: Após oito semanas, verificou-se que tanto no grupo A como no B houve alterações estatisticamente significantes (ES) na RFMD em todos os exercícios (p = 0,007 a 0,008). A análise da melhora percentual e do delta da RFMD, nos exercícios de agachamento, desenvolvimento e supino fechado, mostrou que o grupo A teve alterações positivas ES superiores ao grupo B (p = 0,008 a 0,038). A massa magra aumentou ES somente no grupo A (p = 0,038). Contudo, o percentual de gordura corporal não mostrou alterações em nenhum dos grupos. A relação entre a melhora percentual (MP) das circunferências (C) do braço e antebraço e a MP na RFMD do exercício de desenvolvimento foi ES (r = 0,481 e 0,546, respectivamente), bem como entre a MP na C da coxa e na MP da RFMD do exercício de agachamento (r = 0,619). CONCLUSÃO: Independente do suplemento ingerido o treinamento de força foi capaz de induzir ajustes positivos na RFMD; contudo, a suplementação de creatina mostrou-se mais eficiente que o placebo, induzindo a maior aumento percentual e de delta na força.

OBJECTIVE: To verify the alterations promoted by creatine supplementation in the anthropometric variables and the resultant of dynamic maximum strength (RDMS) in college students submitted to 8 wk of strength training. METHODOLOGY: The sample consisted of 18 male college students, aged between 19 to 25 years. Height (cm), body mass (kg) and tests of maximum voluntary muscular action (1MVMA) weight in the squat were determined prior to the training. The subjects were divided in two groups: A (creatine) or B (placebo).The double-blind protocol was adopted. After 8 weeks of strength training, the tests battery from the pre-training was repeated. RESULTS: After 8 wk of training, it was verified that both groups had statistically significant (SS) alterations in the RDMS in all the exercises (p = 0.007 / 0.008). The analysis of the percentile improvement (PI) and the RDMS delta in the squat exercises, military press and close-grip-extensions, showed that group A had positive SS alterations higher than group B (p = 0.008 / 0.038). Lean body mass only SS increased in group A (p = 0.038). However, the percentage of body fat did not show alterations in none of the groups. The relationship between the PI of the arm and forearm circumferences (C) and the PI in the RDMS of the development exercise was SS (r = 0.481 and 0.546, respectively), as well as between the PI in the thigh C and the PI of the RDMS of the squat exercise (r = 0.619). CONCLUSION: Regardless the substance ingested, strength training was able to increase in RDMS; however, creatine supplementation was shown to be more efficient that the placebo, showing higher percentual and delta improvement in strength.