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Background: Trauma induced by endoscopic surgery may inhibit erythrocyte immune function and activate inflammatory responses, however, there are certain differences between different surgical methods. Aims: To investigate the effect of endoscopic mucosal resection (EMR) on erythrocyte immune function and inflammatory cytokines in patients with gastrointestinal polyps. Methods: A total of 315 patients with gastrointestinal polyps in Meishan People's Hospital from Jan. 2011 to Dec. 2016 were collected and randomly allocated into EMR group (n=160) and control group (n=155), and underwent EMR and routine endoscopic electrocoagulation resection, respectively. The resection rate, postoperative erythrocyte immune function, including peripheral blood red-cell membrane complement 3b receptor rosette (C3bRR), immune complex rosette (ICR), CD58 and CD59, as well as serum inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, IL-8 and IL-12 were compared between the two groups. Results: All gastrointestinal polyps were removed successfully in both groups. Less intraoperative complications were observed in EMR group than in control group (3.1% vs. 20.0%, P<0.05). The postoperative levels of C3bRR, CD58 and CD59 on red-cell membrane in EMR group were significantly higher than those in control group (P<0.05), while the postoperative levels of ICR, and serum IL-1β, IL-6, IL-8 and IL-12 were significantly lower in EMR group than in control group (P<0.05). Conclusions: EMR is effective for treatment of gastrointestinal polyps with lower intraoperative complications. Furthermore, it may protect the erythrocyte immune function and suppress the inflammatory responses caused by surgery.
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OBJECTIVE:To observe clinical efficacy of extracorporeal shock wave lithotripsy combined with Paishi decoction in the treatment of kidney stone. METHODS:160 patients with kidney stone were selected and randomly divided into observation group and control group,with 80 cases in each group. Control group only received HB-ESWL-VG extracorporeal shock wave litho-tripsy;observation group additionally received Paishi decoction 300 ml,tid,for consecutive 1 week,on the basis of control group. Clinical efficacy was observed in 2 groups;the levels of serum inflammatory factor IL-2,IL-6,TNF-α,T lymphocyte subset CD3+,CD4+,CD8+ and CD4+/CD8+,erythrocyte immune function indicator C3b receptor rosette(C3bRR),immunity complex ro-sette(ICR)and tumor erythrocyte rosette(TER)level were detected in 2 groups before and after treatment. RESULTS:The effec-tive rate of observation group(98.75%)was significantly higher than that of control group(91.25%),with statistical significance (P0.05). CONCLUSIONS:The extracor-poreal shock wave lithotripsy combined with Paishi decoction can relieve inflammation reaction,enhance immune function and im-prove therapeutic efficacy.
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Objective To investigate the effects of astragalus membranaceus parenteral solution combined with recombinant human erythropietin (rHuEPO) on erythrocyte immunity function in patients with hemodialysis. Methods Fifty-one patients of chronic renal failure(CRF) with hemodialysis were divided into 2 groups randomly according to whether treated with astragalus membranaceus parenteral solution or not(therapeutic group, was 26 cases and control group was 25 cases). IgG, IgA, IgM, RBC-C3b,RR,RBC-ICR, erythrocyte percentage of CD35 positive and SOD was measured before treatment and 8 weeks after treatment. Results After 8 weeks' treatment, IgG,IgA,IgM levels in therapeutic group and IgG,IgA levels in control group were higher than those before treatment(P < 0.01 ). IgM [ (2.03±0.73 ) g/L ] was higher than that in control group (P< 0.05). RBC-C3B,RR, erythrocyte percentage of CD35 positive and SOD were higher and RBC-ICR was lower than those before treatment in two groups (P < 0.05 ) ;compared with that in control group, RBC-C3b, RR was higher [(10.85±2.31 )% ] and RBC-ICR was lower [(5.34±1.91 )% ] (P < 0.05 ).Conclusion Astragalus membranaceus parenteral solution combined with rHuEPO is superior to improve CRF patients' levels of immune globulin and erythrecyte immunity function.
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0.05), and the all had significant differences in 2 to 4 months post-infection compared with the normal controls (P