ABSTRACT
Introduction : The Cardiovascular mortality in Diabetics is 2-4 times higher than in Non-diabetic population. But there is still controversy regarding Pre-diabetes (IFG and IGT) as a Cardiovascular Risk Factor. Aims and Objectives : In this study we aimed to investigate the early in-hospital mortality among Acute Myocardial Infarction (AMI) patients having Impaired Fasting Glucose (IFG) during the first 7 days of hospitalization. Materials and Methods: A total of 150 AMI patients were evaluated and followed up for their glycemic status and early in hospital mortality (first 7 days) at Burdwan Medical College, Burdwan, West Bengal. Result and Analysis: Mortality in patients having IFG (18%) was higher and as much as in DM (20%) compared to euglycemic (4%) patients but the mortality is not correlated with mean Fasting Plasma Glucose (FPG) level. Conclusion : IFG (ie, pre-diabetes) increases Cardiovascular mortality as much as diabetes. So, IFG may be a marker or risk factor for mortality but lowering FPG in AMI patients is unlikely to yield beneficial effect regarding mortality.
ABSTRACT
Objective: To analyze and compare the clinical value of serum 1,5-anhydroglucitol (1,5-AG) with glycated albumin (GA) combined with fasting plasma glucose (FPG),respectively,in screening diabetes mellitus in Chinese population at the risk of diabetes mellitus. Methods: A total of 701 subjects with high risk of diabetes were enrolled in this study,including 324 males and 377 females. All subjects underwent 75 g oral glucose tolerance test (OGTT). Diabetes was diagnosed according to the cut-off points of 2010 American Diabetes Association standards. The sensitivity,specificity and area under ROC curve (AUC) of GA combined with FPG and 1,5-AG combined with FPG in screening diabetes mellitus were analyzed. Results: Among 701 subjects,350 (49.93%) cases were diagnosed as having diabetes mellitus. The sensitivity,specificity,and AUC of 1,5-AG combined with FPG were 84.29%,91.45% and 0.939,respectively. The sensitivity of GA combined with FPG was 77.71%,and the specificity and AUC were 90.88% and 0.932,respectively. There was no significant difference in AUC between the two screening methods (P>0.05),but the sensitivity of 1,5-AG combined with FPG was higher than that of GA combined with FPG (P=0.001). The proportion of the subjects in need of further OGTT judged by 1,5-AG combined with FPG was 27.82%,which was 11.27% lower than that judged by FPG alone,and 2.57% lower than that judged by GA combined with FPG. Conclusion: In Chinese population with high risk of diabetes mellitus,serum 1,5-AG or GA combined with FPG can improve the efficiency of diabetes screening. Compared with GA combined with FPG,1,5-AG combined with FPG may have more clinical value.
ABSTRACT
Background Liver is the central hub for metabolism. Liver dysfunction in diabetes mellitus is one of the major causes of morbidity and mortality. Periodical evaluation of transaminases helps in early diagnosis of liver dysfunction. Aim The aim of the present study is to measure aspartate transaminase (AST) and alanine transaminase (ALT) in known cases of type 2 diabetes mellitus (T2DM) and to compare the values with matched controls. Settings and Design Institutional cross-sectional observation study. Methods & Material Study was done in 100 known cases of T2DM and in 30 controls. Age, AST, ALT and fasting plasma glucose (FPG) were recorded, analysed and compared between two groups. Statistical Analysis Data was analysed using Microsoft Excel 2007 and SPSS trial version 16.0. Results Significant difference between FPG, AST, ALT and age were observed between two groups (P < 0.05). Conclusion The results from our study showed that there are elevated levels of ALT and ASTs among T2DM patients when compared with normal individuals.
ABSTRACT
Background and objectives Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in diabetic patients and predict risks for the development and/or progression of diabetic complications. Glycosylation process depends on the exposure to glucose. Studies on chronic complications of diabetes established the role of glycosylated hemoglobin (HbA1c) as a marker of evaluation of long term glycemic control and risk for chronic complications. The aim of this study is to evaluate the significance of calculated HbA1c by using fasting plasma glucose levels and comparison with duration of diabetes mellitus. Materials and methods The present study has 2 groups of subjects, 27 normal and 32 diabetic subjects. The diabetic subjects were divided into 2 groups based on complication i,e cataract and nephropathy with duration of diabetes. Plasma glucose was estimated by GOD – POD method. Estimation of glycated hemoglobin was done by calculation. Results and conclusion We found the significance in the duration of diabetes and the levels of glycated hemoglobin and fasting glucose levels were significantly increased in diabetic group as compared to normal subjects (p<0.001). Thus, calculated HbA1c levels can be used with regular checkups of FPG and HbA1c levels in diabetic patients at lesser cost.