ABSTRACT
La mucinosis folicular se caracteriza por depósito anómalo de mucina, en los folículos pilosos y glándulas sebáceas. Puede corresponder a un trastorno idiopático benigno y auto-limitado, especialmente en niños o representar un cuadro secundario a un trastorno mielo-proliferativo, generalmente un linfoma cutáneo-T. Presentamos el caso de una niña de diez años de edad, con varias placas eritemato-blanquecinas circulares, ocasionalmente pruriginosas, en cara, cuello y tronco, además de alopecia difusa de cinco meses de evolución. No hay ataque al estado general. El estudio histopatológico reportó un cuadro compatible con mucinosis folicular.
Follicular mucinosis is characterized by mucin deposits within the hair follicles and sebaceous glands. It can occur as a primary idiopathic benign disorder; it can; or it can arise as a secondary symptom of a malignant disorder, most commonly mycosis fungoide. Youth and localization in a single area used to be regarded as indicative of the benign nature of follicular mucinosis. We report the case of a ten years old girl who presented with a five months history of a multiple, slightly pruritic, erythematous patches on her face, neck and chest. Different local treatments were ineffective. Overall, she was healthy. Histopathological examination of the lesion showed the typical histological picture of follicular mucinosis.
ABSTRACT
Las lesiones de Mucinosis folicular suelen localizarse en cabeza y más raramente extenderse a cuello, tronco y extremidades. Los hallazgos histológicos se caracterizan por la degeneración reticular del folículo pilosebáceo y el depósito de glicosaminoglicanos (mucina). Se presenta un caso de Mucinosis folicular generalizada, en una paciente de sexo femenino de 35 años de edad. Al examen dermatológico se visualizaban múltiples pápulas eritematosas, con predominio en tórax región posterior y cuero cabelludo, acompañadas de placas localizadas en pliegues y alopecia difusa. El segundo caso es de una paciente de sexo femenino de 26 años de edad. A la inspección presentaba placa eritematosa y nódulos dolorosos. Se destaca la necesidad de seguimiento clínico e histológico, ante la posibilidad de transformación a linfoma cutáneo.
The injuries of Follicular mucinosis usually are located in head or more rarely to become general to neck, trunk and extremities. The histological findings are characterized by the reticular degeneration of the pilosebaceous follicle and the deposit of glicosaminoglicans (mucin). A case of generalized Follicular mucinosis in a patient of feminine sex of 35 years of age appears. The dermatological examination revealed manifold papules with predominance in later thorax erythematous region and hairy leather, accompanied by plates that were located in you fold and diffuse alopecia. The second case is a patient of feminine sex of 26 years of age. The dermatological examination erythematous plate with painful nodules to the palpation was observed. The necessity of clinical and histological pursuit stands out before the cutaneous possibility of transformation to lymphoma.
ABSTRACT
Follicular mucinosis (FM) is an epithelial reaction pattern that is characterized by the accumulation of mucinous material in the epithelial hair follicle sheath and the sebaceous glands. Although various pharmacological agents have been employed in an attempt to treat FM, effective therapeutic options have remained elusive. We experienced a recalcitrant form of primary FM that we successfully treated with indomethacin and low-dose intralesional interferon alpha (IFN alpha), respectively. To the best of our knowledge, the primary type of FM that responded to indomethacin and low-dose IFN alpha, respectively, in a single case has not been reported in the English medical literature.
Subject(s)
Hair Follicle , Indomethacin , Interferon-alpha , Interferons , Mucinosis, Follicular , Mucins , Sebaceous GlandsABSTRACT
Follicular mucinosis, also known as alopecia mucinosa, is a rare disease characterized by mucinous follicular degeneration and may be accompanied by cutaneous lymphoma, particularly mycosis fungoides. Two categories of disease have been identified in patients with the benign primary form. The first occurs in younger patients with localized lesions and spontaneous regression within 2 years of the onset. The second occurs in elderly patients and shows a chronic relapsing, but benign course. In the second type, the patients are older and have widespread and infiltrated lesions that can progress to mycosis fungoides. We report a case of follicular mucinosis in a 5-year-old girl who had widely distributed lesions. We think that long-term follow-up is mandatory for the occurrence of lymphoma-associated disease.
Subject(s)
Aged , Humans , Follow-Up Studies , Lymphoma , Mucinosis, Follicular , Mucins , Mycosis Fungoides , Child, Preschool , Rare DiseasesABSTRACT
Eosinophilic pustular folliculitis (Ofuji's disease) is characterized by inflammatory infiltration of the pilosebaceous units by numerous eosinophils. Clinically, recurrent crops of papules and plaques studded with sterile follicular pustules can be seen. Follicular mucinosis is a reaction pattern which occurs in the follicular epithelium and is characterized by a mucinous degeneration of the outer sheath of follicles and sebaceous glands. The condition can occur in various diseases. Herein, we report a case of a 46-year old woman who presented with a recurrent episode of papules and follicular pustules, revealing inflammatory infiltration in and around the pilosebaceous units and prominent eosinophils, in addition to follicular mucinosis.
Subject(s)
Female , Humans , Middle Aged , Eosinophils , Epithelium , Folliculitis , Mucinosis, Follicular , Mucins , Sebaceous GlandsABSTRACT
We presented here a case of a 53-year-old male patient who was confirmed as follicular mucinosis associated with mycosis fungoides. He showed erythematous infiltrative papules and plaques on the face, scalp, trunk and extremities. Some of the lesions were observed as mycosis fungoides. A biopsy specimen showed both findings of follicular mucinosis and mycosis fungoides, such as reticular degeneration of follicles, deposit of mucin, Pautrier's microabscess, epidermotropism, rather dense perifollicular or perivascular infiltrates, and the presence of significant proportions of admixed eosinophils and plasma cells. To our best knowledge, this is the first reported case of follicular mucinosis associated with mycosis fungoides in Korea.
Subject(s)
Humans , Male , Middle Aged , Biopsy , Eosinophils , Extremities , Korea , Mucinosis, Follicular , Mucins , Mycosis Fungoides , Plasma Cells , ScalpABSTRACT
We report a case of follicular mucinosis in a 12-year-old girl. She had an erythematous indurated plaque with an ill-defined border on the chin. A biopsy specimen showed reticular degeneration, cystic space formation, and abundant mucin deposition in pilosebaceous follicles. She had been treated with topical corticosteroid for 3 months. The skin lesion was completely resolved.