Expression of AP-1 subunits in skin tumor and its significance / 中国癌症杂志

Purpose:AP-1(activator protein-1) is closely associated with cell differentiation,proliferation,apoptosis and tumorigenesis.We investigated the expression of AP-1 subunits in skin tumor and its adjacent skin tissue and their roles in the occurrence and development of skin tumor.Methods:ABC immunohistochemistry was applied to detect c-jun,p-c-jun,JunB,JunD,c-fos,Fra-1,and Fra-2 expression in skin basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma.Results:The expression of c-jun and p-c-jun were increased dramatically in basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma and JunB was decreased sharply in basal cell carcinoma.Conclusions:c-jun is a positive regulator of cell proliferation and tumorigenesis in skin.JunB has an antagonistic function for c-jun.

Expression of Fra1 and Fra2 Genes are regulated by Estrogen in the Mouse Uterus / 대한불임학회지

No abstract available.

Fra-1 Expression in Malignant and Benign Thyroid Tumor

BACKGROUND: The differential diagnosis of thyroid nodules is very important in deciding the treatment modality and the fine needle aspiration is the best diagnostic method. But, there are some limitations in use because of inadequate test materials and difficulty in interpreting. According to the study of oncogene and tumor suppressor gene about the origin of thyroid tumor, expression of Fra-1, one of AP-1 complex, is increased in thyroid neoplasm, though not present in the normal tissue. So, there is a possibility that it will be used as a method for the differential diagnosis of thyroid nodules. We tried to know whether presence or absence of Fra-1 expression can be used as a diagnostic method in differential diagnosis of thyroid nodules using the immunohistochemical (IHC) staining method. METHOD: In 4 types of thyroid tumor that were confirmed by histologic diagnosis after operation (18 cases of adenomatous goiter, 16 cases of follicular adenoma, 30 cases of papillary cancer, 10 cases of follicular cancer), IHC staining method was performed to evaluate the expression of Fra-1. RESULT: In papillary and follicular thyroid cancers, the expression of Fra-1 was stronger than in benign thyroid tumor, but there was no difference in Fra-1 expression between the two types of carcinoma. Weak expression of Fra-1 was observed in all cases of follicular adenoma, though it was weaker than in carcinoma, and it was also weakly expressed only in some cases (33%) of adenomatous goiter. CONCLUSION: The expression of Fra-1 was stronger in thyroid cancer than in benign thyroid tumor, but it was impossible to differentiate thyroid cancer from benign thyroid tumor by presence or absence of Fra-1 expression using IHC staining method.