ABSTRACT
Objective: To study the chemical constituents from Fritillaria pallidiflora. Methods: The constituents were isolated from F. pallidiflora and purified by column chromatography, and the structures were identified by spectra analysis and chemical methods. Results: Sixteen compounds were isolated from F. pallidiflora, including phenolic acids, esters, alkaloids, and the structures were identified as 1,4-diphenylbutane (1), cis-cinnamic acid (2), 4-hydroxy-3-methoxybenzaldehyde (3), acetovanillone (4), 9-octadecenoicacidmethylester (5), methyl ferulate (6), 1-O-feruloylglycerol (7), trans-isoferulic acid (8), syringaresinol (9), pinoresinol (10), 2,3-O-diferuloylglycerol (11), 1,3-O-diferuloyl-glycerol (12), cyclo (L-Pro-L-Ala) (13), cyclo (L-Leu-L-Val) (14), bis (diethylene glycol)phthalate (15), and cyclo-(Phe-Val) (16). Conclusion: All compounds are isolated from F. pallidiflora for the first time, and componds 1, 3-8, 10-13, 15, and 16 are isolated from the genus of Fritillaria for the first time.
ABSTRACT
Objective: To investigate the chemical constituents in the bulbs of Fritillaria pallidiflora collected from Xinjiang province, China. Methods: Compounds 1-4 were separated and purified by column chromatographies with silica gel, preparative TLC. Their chemical structures were elucidated on the basis of spectroscopic (MS, NMR, etc) methods. Results: Four compounds, yibeirine (1), yibeisine (2), 2'-methoxyseselin (3), and 1-O-β-D-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2'R)-(2'-hydroxydocosanoyl) amido]-1,3,4-octadecanetriol-8-ene (4), were isolated from cyclohexane fraction of 80% aqueous ethanol extract from the bulbs of F. pallidiflora. Conclusion: Compounds 1 and 2 are new steroidal alkaloids.