ABSTRACT
Background: This was a descriptive cross-sectional study conducted in a tertiary care hospital in south India during the peak of the COVID-19 infection pandemic in India between June 2020 to June 2021. HRCT lung parenchymal findings of patients with COVID-19 infection were studied, and the pattern and distribution of various lung parenchymal changes in each lung were described. HRCT lung findings were further correlated with clinical findings and clinical severity, which further helped in the clinical management of patients. Methods: This descriptive cross-sectional study was done at Sagar Hospitals, Tilak Nagar, Jayanagar, Bengaluru on a total of 111 RT-PCR positive COVID-19 patients in the age group 18 to 80. HRCT lung imaging findings were studied from June 2020 to June 2021 during the pandemic. These findings were further correlated with clinical findings and the clinical severity of the patient. Results: This study showed that chest CT findings in COVID-19 infection are variable. Ground glass opacity was the most common lesion observed, followed by Air space opacification and consolidation with an air bronchogram. In some cases, a crazy-paving pattern, subpleural linear bands, subpleural reticulations and fibrotic streaks were observed. A few cases showed traction bronchiectasis due to adjacent lung fibrosis and lung cyst within lesions. The lesion distribution was both bilateral (more common) and unilateral and showed peripheral predominance. There was a positive correlation between the CT severity score and clinical grading and the clinical severity of the patient. Conclusions: HRCT lung findings in COVID-19 patients were described in detail, including predominant lesion, predominant pattern, distribution in detail with reference to each lung segment, laterality, and correlation with clinical severity.
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@#Objective To investigate CT image features of ground glass opacity (GGO)-like 2019 novel coronavirus (2019-nCoV, SARS-CoV-2) pneumonia (COVID-19) and early-stage lung carcinoma for control and therapy of this acute severe respiratory disease. Methods We retrospectively analyzed the clinical data of 71 GGO-like COVID-19 patients who received therapy in Tongji Hospital of Huazhong University of Science and Technology between January 17th and February 13th, 2020. These 71 GGO-like COVID-19 patients were as a COVID-19 group. And 80 GGO-like early-stage lung carcinoma patients who underwent resection were as a lung carcinoma group. Clinical features such as sex, age, symptoms including fever, cough, fatigue, myalgia and dyspnea, detailed exposure history, confirmatory test (SARS-CoV-2 quantitative RT-PCR) and pathologic diagnosis were analyzed. Results Significantly different symptoms and exposure history between the two groups were detected (P<0.001). More lesions (61 patients at percentage of 85.92%, P<0.001), relative peripheral locations (69 patients at percentage of 97.18%, P<0.001) and larger opacities (65 patients at percentage of 91.55%, P<0.001) were found in chest radiographs of GGO-like COVID-19 compared with GGO-like early-stage lung carcinoma. Similar features appeared in early-stage of COVID-19 and lung carcinoma, while pneumonia developed into more extensive and basal predominant lung consolidation. Coexistence of GGO-like COVID-19 and early-stage lung carcinoma might occur. Conclusion Considering these similar and unique features of GGO-like COVID-19 and early-stage lung carcinoma, it is necessary to understand short time re-examination of chest radiographs and other diagnostic methods of these two diseases. We believe that the findings reported here are important for diagnosis and control of COVID-19 in China.
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Objective To evaluate the clinical and CT manifestations of coronavirus disease 2019 (COVID-19). Methods Serial clinical and CT data of 11 patients with confirmed COVID-19 were retrospectively analyzed. These data were collected in The Second Affiliated Hospital of Xi'an Jiaotong University from January 24 to February 9, 2020. There were 6 males and 5 females, aged from 17 to 64 years old, with the mean age of 42.27±15.67. Results A majority of the patients fell into mild type and only one was of severe type. Clinical manifestations were mainly fever, fatigue, and dry cough. For laboratory tests, the patients' lymphocyte and eosinophil counts decreased, while their C-reactive protein concentration increased. In terms of CT findings, 7 patients showed bilateral subpleural involvement. The ground glass opacity (GGO) was common in CT findings. Typical crazy paving sign, air bronchogram and halo sign were also found. During the progression of the disease, GGO might be associated with pulmonary consolidation. No enlarged lymph nodes or pleural effusion were seen in all the patients. Conclusion Patients with COVID-19 have distinctly characteristic chest CT manifestations and laboratory examination findings, which play a vital role in diagnosis and prognosis of the disease.
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Objective In 2011's new IASLC-ATS-ERS(International Association for the Study of Lung Cancer,American Thoracic Society,and European Respiratory Society) lung adenocarcinoma classification,adenocarcinoma in situ and minimally invasive adenocarcinoma(MIA) substituted for bronchioloalveolar carcinoma.The excellent prognosis wins these two histologic types a lot of attention.With the development of image technology,more and more lung adenocarcinomas are detected in early stage.Tumors showing a ground-glass nature in preoperative CT scans are more likely to be minimally invasive adenocarcinoma.This review discusses from the following 6 aspects.Imaging characteristics of MIA,the diagnostic value of intraoperative frozen section,preoperative localization,selection of surgical approaches for ground-glass opacity(GGO) nodules,the extent of lymph nodes dissection and management of multiple primary lung adenocarcinoma.The clinical guideline for early-stage lung adenocarcinoma is still controversial,strong evidence and further studies are needed.
ABSTRACT
Objective In 2011's new IASLC-ATS-ERS(International Association for the Study of Lung Cancer,American Thoracic Society,and European Respiratory Society) lung adenocarcinoma classification,adenocarcinoma in situ and minimally invasive adenocarcinoma(MIA) substituted for bronchioloalveolar carcinoma.The excellent prognosis wins these two histologic types a lot of attention.With the development of image technology,more and more lung adenocarcinomas are detected in early stage.Tumors showing a ground-glass nature in preoperative CT scans are more likely to be minimally invasive adenocarcinoma.This review discusses from the following 6 aspects.Imaging characteristics of MIA,the diagnostic value of intraoperative frozen section,preoperative localization,selection of surgical approaches for ground-glass opacity(GGO) nodules,the extent of lymph nodes dissection and management of multiple primary lung adenocarcinoma.The clinical guideline for early-stage lung adenocarcinoma is still controversial,strong evidence and further studies are needed.