ABSTRACT
Se realizó un estudio descriptivo y transversal de 125 pacientes con cáncer de pulmón, ingresados y diagnosticados en el Servicio de Neumología del Hospital General Docente Dr Juan Bruno Zayas Alfonso de Santiago de Cuba, de enero de 2015 a octubre de 2016, con vistas a caracterizarles según variables clínicas y epidemiológicas de interés, además de factores de riesgo genéticos y no genéticos, independientemente de las características histológicas y el estadio clínico del proceso neoplásico. Entre los resultados preponderantes figuraron el sexo masculino y el grupo etario de 51-69 años -- aunque fue evidente el incremento del número de féminas y de pacientes en las edades más jóvenes de la vida --, igualmente la broncoscopia como método diagnóstico, la localización en el pulmón derecho, el adenocarcinoma como variedad histológica, el tabaquismo entre los factor de riesgo no genético y el parentesco de primer grado en los factores genéticos. La mayoría de los afectados presentaban menos de un año de evolución y un elevado porcentaje correspondía al estadio IV de la enfermedad.
A descriptive and cross-sectional study of 125 patients with lung cancer, admitted and diagnosed in the Pneumology Service of Dr Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba was carried out from January, 2015 to October, 2016, aimed at characterizing them according to clinical and epidemiological variables of interest, besides genetic and non genetic risk factors, independently from the histological characteristics and the clinical stage of the neoplastic process. Among the predominant results there were the male sex and the age group 51-69, although the increment of the females and of patients in the youngest ages in the life was evident --, equally the bronchoscopy as diagnostic method, the localization in the right lung, the adenocarcinoma as histological variety, smoking habit among non genetic risk factors and the first degree relation in the genetic factors. Most of the affected patients presented a clinical course shorter than a year and a high percentage were in the stage IV of the disease.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Adenocarcinoma/diagnosis , Risk Factors , Lung Neoplasms/epidemiology , Secondary Care , Bronchoscopy , Pulmonary Medicine , Cross-Sectional Studies , Genetic Diseases, InbornABSTRACT
Non-syndromic oral clefts (NSOC) are among the most common birth defects.The prevalence of NSOC is 1.13-1.30 per 1 000 live births in China,which is higher than those in other major ethnic groups.The etiology of NSOC is complex and heterogeneous,which involves both genetic and environmental risk factors.Although genome-wide association studies have identified a number of risk loci,these loci can only account for a small proportion of the heritability of NSOC.The next-generation sequencing research provides new ideas for further exploring the genetic risk factors of NSOC.This paper summaries the progress in the next-generation sequencing research of NSOC.
ABSTRACT
Non-syndromic oral clefts (NSOC) are among the most common birth defects.The prevalence of NSOC is 1.13-1.30 per 1 000 live births in China,which is higher than those in other major ethnic groups.The etiology of NSOC is complex and heterogeneous,which involves both genetic and environmental risk factors.Although genome-wide association studies have identified a number of risk loci,these loci can only account for a small proportion of the heritability of NSOC.The next-generation sequencing research provides new ideas for further exploring the genetic risk factors of NSOC.This paper summaries the progress in the next-generation sequencing research of NSOC.
ABSTRACT
Chronic obstructive pulmonary disease (COPD) refers to a common complex disease characterized by progressive and incomplete reversible airflow limitation.COPD is one of the leading causes on morbidity and mortality in China.Genetic risk factors play important roles on the occurrence of COPD.However,the genetic risk factors of COPD remain unknown,to some extent.The aim of this review is to provide a comprehensive overview on literature concerning the most promising findings related to genetic risk factors of COPD.
ABSTRACT
Chronic obstructive pulmonary disease (COPD) refers to a common complex disease characterized by progressive and incomplete reversible airflow limitation.COPD is one of the leading causes on morbidity and mortality in China.Genetic risk factors play important roles on the occurrence of COPD.However,the genetic risk factors of COPD remain unknown,to some extent.The aim of this review is to provide a comprehensive overview on literature concerning the most promising findings related to genetic risk factors of COPD.