Probable Controversy of Cardiac Resynchronization Therapy on the Adaptive Energy Metabolism of Hypertrophied and Insufficient Heart in Democratic Republic of Congo

Background: It is reported that 20 to 30% of patients are not responders to this treatment (Cardiac Resynchronization Therapy). The reasoning in this merely theoretical paper shows the plausible danger that can be brought by measurements apparatus, in the occurrence the CRT especially when it is sophisticated. Objective: In Physical Cardiochemistry field our overall purpose is to bring a contribution to heart health. It is needful to draw attention for caregivers and manufacturers, especially with respect to the magnetism these apparatuses may exhibit. Methods: The Observation and documentary research are used. It is recalled hereby successively energy metabolism in healthy cardiomyocyte, adaptive energy metabolism of a hypertrophied and insufficient heart, cardiac resynchronization therapy and energy metabolism of the cardiomyocyte with its potential effects on both glucose oxidation and fatty acids oxidation. Results: It is shown a plausible interaction between oxygen magnetic field, paramagnetic by nature, and pacemaker and/or defibrillator electromagnetic field according to the sacral principle of “like dissolves like” with all evil consequences on patients. Conclusion: It will be necessary to evaluate later not only the behavior of the various energetic substrates of a hypertrophied heart as a function of the variation of the magnetic field strength but also the content of the probable substances produced in the presence of a magnetic field and with a potentially harmful effect on cardiac function. Convinced technology has its setbacks, the pacemakers and/or defibrillators manufacturers are invited to a greater rigor, greater caution and sustained care in building these devices. In next publication study of a case (CRT-D), where the diabetes has been observed, will be outlined.

Fat gain with physical detraining is correlated with increased glucose transport and oxidation in periepididymal white adipose tissue in rats

As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes.

Fabrication of Flower-Shaped Pt-Au-graphene Nanostructures and Their Application in Electrochemical Detection of Glucose / 分析化学

The flower-shaped Pt-Au-graphene oxide ( GO ) nanostructures were synthesized by one-step electrochemical reduction method. The electrocatalytic activities of the nanostructures toward glucose oxidation were investigated by cyclic voltammetry. The results indicated that the nanocomposites exhibited a higher electrocatalytic activity than the Pt-Au nanoparticles. A glucose nonenzyme sensor could be easily developed with the use of the flower-shaped Pt-Au-GO nanostructure. The sensor exhibited low detection limit (4. 0 μmol/L), a wide and useful linear range (1. 0-25. 0 mmol/L), and high sensitivity (26. 3 μA cm-2 ( mmol)-1 ) . In addition, the sensor exhibited excellent reproducibility, stability and selectivity for the determination of glucose, and it could be used to analyze real samples.

Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation

The effects of carnosine and related compounds (CRCs) including anserine, homocarnosine, histidine, and beta-alanine on monosaccharide autoxidation and H2O2 formation were investigated. The incubation of CRCs with D-glucose, D-glucosamine, and D, L-glyceraldehyde at 37degreeC increased the absorption maxima at 285 nm, 273 nm, and 290 ~ 330 nm, respectively. D, L-glyceraldehyde was the most reactive sugar with CRCs. The presence of copper strongly stimulated the reaction of carnosine and anserine with D-glucose or D-glucosamine. Carnosine and anserine stimulated H2O2 formation from D-glucose autoxidation in a dose-dependent manner in the presence of 10 muM Cu (II). The presence of human serum albumin (HSA) decreased their effect on H2O2 formation. Carnosine and anserine has a biphasic effect on alpha-ketoaldehyde formation from glucose autoxidation. CRCs inhibited glycation of HSA as determined by hydroxymethyl furfural, lysine residue with free epsilon-amino group, and fructosamine assay. These results suggest that CRCs may be protective against diabetic complications by reacting with sugars and protecting glycation of protein.