ABSTRACT
Aim:The aim of our study was to estimate the level of HbA1c in patients with Acute Coronary Syndrome (ACS). To determine any correlation between HbA1c, admission blood glucose (Random blood sugar), serum lipid profile among the cases and to evaluate the outcome during hospitalization. Study Design and Setting:Cohort study.Place and Duration of the Study:Department of Biochemistry and General Medicine including ICCU and Cardiology unit, RIMS, Imphal, between September 2015 to August 2017.Methodology:Data were collected from 98 patients admitted in Medicine ward who were diagnosed with ACS irrespective of their diabetes status and they were divided into three groups according to their HbA1c levels (<5.7%, 5.7-6.4%, > 6.5%). The blood samples collected by venipuncture were analyzed for HbA1c level, done by RANDOX HbA1c Rx series (latex agglutination inhibition assay), admission blood glucose (measured by Trinder’s method) and serum lipid profile (RANDOX enzymatic Endpoint Method Rx series). The data were analyzed using statistical tools like Chi Square test, Independent sample t test, Pearson’s Correlation, Fisher’s exact test through SPSS 21.0.Results:Majority of the patients were men (72.4%) & (27.6%) women and in the age group of 51-65 years. The mean ageis 62.14 years. 54.1% of the ACS patients were already diagnosed cases of type 2 diabetes mellitus whereas 45.9% were non-diabetic. Out of 98 patients, 60 had HbA1c level in the diabetic range (≥6.5%), 25 in the pre-diabetic range (5.7-6.4%) and the remaining 13 were within normal range (<5.7%). Admission blood glucose, total cholesterol and LDL were positively correlated with HbA1c value. Conclusion:The mortality of the ACS patients irrespective of diabetic status during hospitalization was associated with HbA1c value irrespective of diabetic status during hospitalization. However, it was not associated with thirty days mortality
ABSTRACT
Background: The incidence of type-2 Diabetes Mellitus has increased world-wide making it a major public health problem. Electrolyte and mineral abnormalities are common in patients with type-2 Diabetes Mellitus. Therefore, this study was undertaken to look for the correlation between HbA1c (glycated hemoglobin) and serum calcium levels in patients with type-2 Diabetes Mellitus. Aim:To study the correlation of serum calcium levels with glycated hemoglobin (HbA1c) levels in type-2 Diabetic patients. Materials and Methods: A total of 130 type 2 Diabetic patients and 130 healthy non Diabetic people of age (30-55) years were included for the study. Both fasting and post prandial blood samples were collected from the two groups and were used for fasting blood sugar, HbA1c, serum calcium and post prandial blood sugar determination. Unpaired student's t-test was used to compare the results between the diabetic and nondiabetic group. Results:The results showed a significant decrease in the serum calcium levels (p < 0.001) in the type 2 Diabetic patients when compared to the non Diabetic control group, whereas HbA1c levels were significantly increased in the diabetic group when compared to the non-diabetic group (p < 0.001). Also, type 2 Diabetic patients showed a statistically significant negative correlation (r = -0.732, P-value= 0.00) between their HbA1c and serum calcium levels. Conclusion: Type 2 Diabetic patients with poor glycemic control are at increased risk of developing hypocalcemia when compared to those with good glycemic control
ABSTRACT
Background and objectives Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in diabetic patients and predict risks for the development and/or progression of diabetic complications. Glycosylation process depends on the exposure to glucose. Studies on chronic complications of diabetes established the role of glycosylated hemoglobin (HbA1c) as a marker of evaluation of long term glycemic control and risk for chronic complications. The aim of this study is to evaluate the significance of calculated HbA1c by using fasting plasma glucose levels and comparison with duration of diabetes mellitus. Materials and methods The present study has 2 groups of subjects, 27 normal and 32 diabetic subjects. The diabetic subjects were divided into 2 groups based on complication i,e cataract and nephropathy with duration of diabetes. Plasma glucose was estimated by GOD – POD method. Estimation of glycated hemoglobin was done by calculation. Results and conclusion We found the significance in the duration of diabetes and the levels of glycated hemoglobin and fasting glucose levels were significantly increased in diabetic group as compared to normal subjects (p<0.001). Thus, calculated HbA1c levels can be used with regular checkups of FPG and HbA1c levels in diabetic patients at lesser cost.