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1.
International Journal of Pediatrics ; (6): 47-50, 2020.
Article in Chinese | WPRIM | ID: wpr-799262

ABSTRACT

Vav-family proteins are guanosine nucleotide exchange factors(GEFs)and one of RhoGEFs family numbers.Vav proteins can influence cell signaling transduction, cytoskeleton recombination and adherence migration in special cells by RhoA, RhoG and Rac-1 pathway.There are 80 kinds of RhoGEFs in mammalian cell.Vav proteins play an important role in hematological system, nervous system, cardiovascular system and immune system.So the function of vav protein in immune system was reviewed in this paper.

2.
International Journal of Pediatrics ; (6): 47-50, 2020.
Article in Chinese | WPRIM | ID: wpr-862922

ABSTRACT

Vav-family proteins are guanosine nucleotide exchange factors (GEFs) and one of RhoGEFs family numbers.Vav proteins can influence cell signaling transduction,cytoskeleton recombination and adherence migration in special cells by RhoA,RhoG and Rac-1 pathway.There are 80 kinds of RhoGEFs in mammalian cell.Vav proteins play an important role in hematological system,nervous system,cardiovascular system and immune system.So the function of vav protein in immune system was reviewed in this paper.

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