ABSTRACT
Objective To explore the predictive performance of EGRIS on the risk of respiratory failure in patients with Guillain-Barrésyndrome (GBS).Methods The medical records of 263 consecutive patients with GBS were retrospectively divided into two groups according to whether respiratory failure occurred during hospitalization . Model performance was quantified by using the receiver operating curve (ROC) analysis.The following parameters, such as the area under the curve (AUC), and cut-off value of the EGRIS, sensitivity and specificity corresponding to the maximum Youden Index , were then obtained.Results There were 28 ( 10.6%) patients in this group developed into respiratory failure during hospitalization.Validation of EGRIS model suggested excellent discriminative ability (AUC＝0.892, 95%CI: 0.835-0.949, P＜0.05), with a cut-off score of 3.5 found to be highly sensitive (75%) and specific (85.1%) for predicting respiratory failure.Conclusion The EGRIS is a simple but accurate model to predict the risk of respiratory failure in the early stage of GBS.
ABSTRACT
INTRODUCCIÓN: El SGB es una polirradiculopatía aguda, que a menudo se asocia a una infección anterior. Constituye una emergencia neurológica. La tríada clásica es paresia simétrica y ascendente, abolición o disminución de reflejos osteotendíneos y parestesias. Se sospecha clínicamente. El tratamiento es de soporte, intercambio de plasma e inmunoglobulina intravenosa. OBJETIVO: Describir las características epidemiológicas y clínicas de pacientes con diagnóstico de SGB del Hospital Clínico Herminda Martin de Chillán entre los años 2010 a 2015. MATERIAL Y MÉTODO: Estudio descriptivo retrospectivo de fichas clínicas de 22 pacientes. Criterios de inclusión fueron tener el diagnóstico de SGB informado en ficha clínica y haber sido atendido en el HCHM durante enero de 2010 y mayo del 2015. Criterio de exclusión es no contar físicamente con la ficha clínica del paciente. Las variables investigadas fueron edad, sexo, estacionalidad, antecedente de infección previa, días de hospitalización y manifestaciones clínicas. RESULTADOS: Predominio de SGB en hombres (63,6%), en individuos de 0-20 años (45,4%), en la época deotoño-invierno (59%) y un 54,5% presentó infección previa. Las manifestaciones clínicas más frecuentes fueron: parestesia (86,3%), paresia muscular (95.4%), arreflexia osteotendínea (86.3%) y dolor muscular (54.5%). 50% de los pacientes tuvo una estadía hospitalaria mayor a cuatro semanas. DISCUSIÓN: La mayoría de las características epidemiológicas y clínicas concuerdan con la literatura y estadísticas internacionales. No obstante, existen diferencias en edad de presentación y estacionalidad.
INTRODUCTION: GBS is an acute polyradiculopathy, which is often associated with a previous infection. It constitutes a neurological emergency. The classic triad is symmetric and ascending paresis, abolition or diminution of osteotendine reflexes and paresthesias. It is clinically suspected. The treatment is support, plasma exchange and intravenous immunoglobulin. The aim of this study is to describe the epidemiological and clinical characteristics of patients with a diagnosis of GBS at the Clinical Hospital Herminda Martin de Chillán between 2010 and 2015. MATERIAL AND METHODS: Retrospective descriptiv estudy of 22 patients` medical records. Inclusion criteria were to have the diagnosis of GBS reported in theclinical record and to have been seen at the HCHM duringJanuary 2010 and May 2016. Exclusion criterion is not to physically counton the patient'sclinical record. The investigated variables were age, sex, seasonality, history of previous infection, clinical manifestations and recovery time. RESULTS: Predominance of GBS in males (63,6%), in the 0-20 years range (45,4%), debuting in autumn-winter (59%) and previous infection in 54,5% of patients. The most frequent clinical manifestations were: paresthesia (86.3%), muscle paresis (95.4%), osteotendinous areflexia (86.3%) and muscle pain (54.5%). 50% of patients recovered in more than four weeks. DISCUSSION: Most of the epidemiology and clinical features are consistent with the literature and international statistics. However, there are differences in age of presentation and seasonality