ABSTRACT
Bariatric surgery is one of the most effective way to lose weight,which suppresses appetite through the central nervous system. The mechanisms of appetite change may include gut hormones, adipokines, as well as microbiota in the intestine.
ABSTRACT
[Summary] The incidences of obesity and its associated diseases are increasing worldwide.Bariatric surgery leads to more sustainable weight loss and better glycemic control compared with conservative medical treatment. Potential mechanisms mediating the improvement in glycemic control after bariatric surgery include changes in the levels of food intake, gastrointestinal hormones, bile acids as well as intestinal bacterial flora.
ABSTRACT
[Summary] Pathophysiological mechanisms of obesity and type 2 diabetes is complex . In recent years ,data has showed that guthormone in obesity and T 2DM patients has changed ,and guthormones such as GLP-1 ,GIP ,PYY ,CCK and ghrelin are strongly related to the development of obesity and diabetes , resulting in a series of metabolic disorders ,this may be one of causes of the development of obesity and T2DM. In recent years ,the guthormone-based treatments or therapies associated with guthormone have became one of the hot topics in the diabetes research. Currently ,some guthormone-based treatment shave been used in clinical treatment of diabetes. This paper is a literature review on the history of gut hormones ,and how it affect the development of diabetes and obesity ,as well as aspects of clinical practice.
ABSTRACT
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
Subject(s)
Animals , Humans , Appetite , Eating , Gastric Bypass , Glucagon-Like Peptide 1 , Obesity , Peptide Hormones , TyrosineABSTRACT
Obesity is prevalent in Korea. An increase in food intake and a decrease in energy expenditure are responsible for obesity. Gut hormones play a role in controlling food intake. Obesity is suggested to be linked to common gastrointestinal functional disorders. Obesity is associated with an increased risk of gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma. Epidemiologic studies indicate that obesity is associated with chronic gastrointestinal symptoms. This association suggests the possibility that obesity and functional gastrointestinal disorders may be pathophysiologically linked. However, data on the relationship between obesity and functional gastrointestinal disorders are inconsistent. In this paper, we review the role of gastrointestinal hormones in food intake and the relationship between obesity and functional gastrointestinal disorders.