A Retrospective Study of Histopathology and Clinical Correlation of Spinal Meningioma at Thoothukudi Medical College, India

The study was conducted to understand the clinical algorithm of spinal meningioma. Correlation was done by clinical presentation with radiological features and histopathology .The stress upon to understand the necessity for a team-approach between Clinician, Radiologist and Pathologist and vice versa is emphasised. Aim: To correlate histopathology of spinal meningioma with the Clinical features. Methods: This is a retrospective study of spinal tumours, diagnosed by histopathology as various types of meningioma. All the relevant clinical data of the patients were searched from the ward records. The various Radiological features were collected. Results: The total number of spinal tumours studied during the 8 years period was 86 cases among which 25 cases were diagnosed by histopathology as various types of meningioma conclusively. Spectroscopy provides molecular information with regard to meningiomas and potentially aid in biopsy planning. Surgical resections were done as follows: 20 cases resected as Simpson Grade 1, 5 cases resected as Simpson Grade 2. Venous thromboembolism was seen in 1 patient. Four cases underwent follow up Adjuvant External Beam Radiotherapy. Conclusion: The Simpson grading of resection of meningioma correlated the degree of surgical resection completeness with symptomatic recurrence. Four cases underwent follow up Adjuvant External Beam Radiotherapy with good results .Spinal meningioma needs correlation between Radiologist, Pathologist and Clinician.

A Retrospective Study of Histopathology and Clinical Correlation of Primary Benign Bone tumours at Thoothukudi Medical College, India

The study was conducted to understand the clinical algorithm of benign bone tumours. Correlation was done by clinical presentation with radiological features and histopathology features. The osteogenic tumours are considered as one group because their common characteristic feature is the production of an osteoid or bone matrix by the tumour cells. The cartilaginous tumours have the characteristic feature of production of cartilage matrix. AIM: We have reported 62 cases of bone tumours during the study period of 5 years in the Department of Pathology, Thoothukudi Medical College, India. The cases were thoroughly studied by histopathology and 28 cases were diagnosed as benign tumours among which 8 cases were benign osteoid producing and 20 cases were diagnosed as benign cartilage producing tumours conclusively. The Histopathology diagnosis was correlated with the Radiological features. Methods: We have reported 62 cases of bone tumours during the study period of 5 years in the Department of Pathology, among which 28 cases were diagnosed as benign bone tumours. A total of 8 cases were osteoid producing and 20 cases were cartilage producing tumours conclusively. All the relevant clinical data of the patients were searched from the ward records. The data was stored in the Department computer server was very much useful in the study. The initial step in the assessment of patients with bone tumours is a good medical history, including age, gender, type and duration of symptoms, localization of the mass, and presence of a history of trauma. CT scan was useful in osteoid lesions. MRI Scan played a crucial role in cartilage producing tumours. Tests to assess general health included a complete blood count , differential count , tests for serum electrolytes including calcium, magnesium, phosphate, liver function studies, blood group typing, a coagulation profile, tests for hepatitis and human immunodeficiency virus infection were taken and recorded. Results: The total number of benign bone tumours reported during the 5 years period was 28 cases,. In benign bone tumours osteochondroma was the most common neoplasm. CT scan established the best choice in studying cortical lesions and nidus in osteoid osteoma. CT can identify the calcification of cartilage. In cases of cartilage producing tumours, the T2 weighted MRI with high signal intensity with a lobulated outline made a useful role. MRI can delineate the medullary extent. Multinucleated giant cells were seen in sections of chondroblastoma. Histopathology provided the final conclusive diagnosis. Conclusion: Benign bone tumours frequently pose a diagnostic challenge for general surgical pathologists. Accurate pathologic diagnosis requires careful clinical, radiological and histopathological correlation. The most common benign bone tumour occurring in children is osteochondromas, representing 10 to 15% of all bone tumours and 20 to 50% of all benign bone tumours.

A Case of Fibrous Histiocytoma in Orbit

Fibrous histiocytoma is a slow-growing mesenchymal tumor that most commonly occurs in soft tissue and retroperitoneum, with an occasional occurrence in the orbit. This mesenchymal tumor should be included in the differential diagnosis of orbital mass in adults because this tumor is radioresistant and prone to recurrences and malignant potential if incompletely excised. So complete excision is the treatment of choice. A case report of a healthy 27-year-old woman with a gradually increasing, non tender superonasal mass and proptosis in the left orbit. She also developed diplopia. CT scan and MRI showed a well-marginated and encapsulated homo-geneous 2 x3 cmsized mass in the superonasal portion of the left orbit. The tumor was totally excised under the impression of carvenous hemangioma. In H-E stain, tumor cell revealed a marked cellularity, storiform arrangement of ovoid to spindle cells but there was little nuclear polymorphism, atypism and absent mitosis. Results of immunohistochemical study showed positive cytoplasmic immunoreactivity to alpha-1-ntitrypsin antibody but negative to S-100 protein, smooth muscle actin, Neuron specific enolase. Masson-Trichrome stain showed positive. The final diagnosis of a benign fibrous histiocytoma invading the orbit was confirmed by histopathological examination. There was no recurrence for more than 14 months after complete surgical excision. We present the above case with a brief review of literature.

A Case of Fibrous Histiocytoma in Cornea and Corneosclerallimbus

Fibrous histiocytoma are complex group of tumors that feature cells resembling fibroblasts and histiocytes.In a case of fibrous histiocytoma involving the cornea and corneolimbus, we evaluated the finding of H-E, Masson-trichrome, reticulin, CD68, alpha-1-antitrypsin antibody and smooth muscle actin antibody stain after the localized excision in 26 years old male patient. In H-E stain, tumor cell included many multinucleated giant cells having abundant eosinophilic and foamy cytoplasm infiltreated by numerous lymphocyte, CD68 & alpha-1-antit-rypsin antibody staining resulted in diffuusely positive finding. Therefore examination. Good result was noted after complete excision at 6 month follow-up.