Human protein tyrosine phosphatase β and its inhibitors: Research advances / 国际药学研究杂志

Human protein tyrosine phosphatase β (HPTPβ) is an endothelial cell-specific receptor protein tyrosine phosphatase(PTP). HPTPβ plays an important role in regulating pathophysiological processes such as angiogenesis and cell-to-cell adherens junction, and is taken as a novel target for developing new antiatherosclerosis and antitumor drugs. In this review, the latest research progress in the structure, physiological functions and small molecular inhibitors of HPTPβ is summarized.

Human protein tyrosine phosphataseβand its inhibitors:research advances / 国际药学研究杂志

Human protein tyrosine phosphataseβ(HPTPβ)is an endothelial cell-specific receptor protein tyrosine phospha?tase(PTP). HPTPβplays an important role in regulating pathophysiological processes such as angiogenesis and cell-to-cell adherens junction,and is taken as a novel target for developing new antiatherosclerosis and antitumor drugs. In this review,the latest research progress in the structure,physiological functions and small molecular inhibitors of HPTPβis summarized.