LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

Endometrial stromal tumors (ESTs) include endometrial stromal nodule (ESN), low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and undifferentiated uterine sarcoma (UUS). Since these are rare tumor types, there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS. Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs, and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (

A Case of High Grade Endometrial Stromal Sarcoma Metastatic to the Lung / 대한산부인과학회잡지

The High grade endometrial stromal sarcoma is very rare. It has occasional local recurrence, which might be arisen from endometrial stroma, from adenomyosis, rarely from endometriosis. We experienced this infrequent malignant tumor in a 33 years old woman showing invasion to endometrium, cervix, adenomyosis and even penetration to the uterine serosa. She underwent total abdominal hysterectomy with bilateral salpinogo-oophorectomy followed by cisplatin-epirubicin chemotherapy. Metastatic pulmonary lesion was found after hysterectomy. The authors report this case with the clinicopathologic findings and brief review of literatures.