ABSTRACT
In the eradication of Helicobacter pylori, China has carried out more than 30 years of efforts. The treatment plan has evolved, but the eradication rate has not increased significantly, and even has a downward trend. How to improve the eradication rate of Helicobacter pylori is an urgent problem for our clinicians. Combined domestic and foreign literature with new clinical progress, this paper reviews from many aspects, such as Hp related factors, drug factors, patient factors, other factors, and many other aspects, in order to provide some help for clinical treatment.
ABSTRACT
Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy .Methods T rials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12 .0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment .Results Eight randomly controlled trials (n=114 4) were includ-ed .Pooled Hp eradication rates were 85.91% and 69 .21% for patients with and without Bifidobacterium viable triple capsule respectively ,with the odds ratio (OR) being 3 .07 (95% CI=2 .25~4 .19 ,test for overall effect Z= 7 .08 , P<0 .01);the occurrences of total adverse reactions were 7 .58% and 20.87% respectively ,with the summary OR being 0 .42 (95% CI=0 .29~0 .61 ,test for overall effect Z= 4 .48 , P< 0 .01) .The difference of the two groups was statistically significant . Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treat-ment and improve adverse reactions during therapy .
ABSTRACT
Objective To discuss the relationship between Hp eradication effect and TCM syndrome types, and provide basis for improving clinical Hp eradication rate of TCM. Methods TCM syndrome types of 922 Hp-positive patients were distinguished. After treatment by the quadruple chemotherapy, the effect of Hp eradication of different TCM syndrome type was analyzed. Results In 922 Hp infectors, Hp eradication effect in different TCM syndrome type from low to high was as follows:spleen-stomach deficiency-coldness, cold-heat complication, stomach-yin deficiency, congestion of stomach collaterals, hyperactive liver-qi harmful to stomach, liver-stomach heat, spleen-stomach dampness-heat, with significant difference (P0.05). Conclusion The eradication rate of Hp infection was different in patients with different TCM syndrome types, which in deficient syndrome is obviously lower than in excessive syndrome.