ABSTRACT
To observe the clinical efficacy of Huazhuo Jiedu formula in treating chronic erosive gastritis (CEG) patients with syndrome of accumulation of turbidity and toxicity, explore its mechanism by observing the changes in expression levels of hypoxia inducible factor (HIF-1α), vascular endothelial growth factor (VEGF) in serum and gastric mucosa tissues after treatment, and provide theoretical basis for the clinical application of Huazhuo Jiedu formula in treating chronic erosive gastritis. All 70 patient of CEG were randomly divided into control group and treatment group, 35 cases in each group. The patients in control group received Alatan Wuwei Wan, bid, 1 bag/time; while the patients in treatment group were given with Huazhuo Jiedu formula, 1 dose/day. The course of the treatment was 6 months in both groups. The changes in clinical symptoms, gastroscopic signs, pathology and the expression levels of HIF-1α, VEGF, and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in serum and gastric mucosa tissues were observed in both groups. The results showed that treatment group was better than control group in clinical efficacy, gastroscopic efficacy and pathological effect after treatment (<0.05); the levels of HIF-1α and VEGF in serum of treatment group were lower than those in the control group after treatment (<0.05), while the level of PTEN in serum of treatment group was higher than that in the control group after treatment (<0.05); the levels of HIF-1α and VEGF in gastric mucosa tissues in the treatment group were lower than those in the control group after treatment, while the level of PTEN in gastric mucosa tissues in treatment group was higher than that in the control group after treatment (<0.05), with statistically significant differences between these two groups (<0.05). Huazhuo Jiedu formula can improve the clinical symptoms, gastroscopic signs and pathological conditions in CEG patients with syndrome of accumulation of turbidity and toxicity, and the mechanism may be associated with decreasing the expression level of HIF-1α, VEGF and increasing the expression level of PTEN.
ABSTRACT
To study the medication regularity of Huazhuo Jiedu Formula in treating the chronic atrophic gastritis (CAG), and to explore the stable relationship of correspondence between Huazhuo Jiedu Formula and the pattern of internal accumulation of zhuodu. Statistical analysis was conducted among 200 cases of CAG, whose case histories included their gender, age, electronic gastroscope, pathological results, clinical symptoms, and prescriptions of Chinese materia medica. On the basis of "golden section method", the association rule between drugs and syndromes was investigated using frequency statistic method and association rule analysis. Through data processing, 153 kinds of Chinese herbal decoction were obtained. According to the principle of "golden section method", 15 kinds of Chinese herbal decoction, whose frequency of use was over 61.8% (including 61.8%), were used as the therapeutical core drugs of pattern of internal accumulation of zhuodu in CAG. Ten kinds of clinical symptoms, which had the high ocurrence rate, were the main symptoms of the pattern of internal accumulation of zhuodu in CAG. According to association rules analysis, it was found that there was a strong correlation between drugs and pulses, which explained the high degree of correspondence of prescription and syndromes between the pattern of internal accumulation of zhuodu in CAG and Huazhuo Jiedu Decoction. It can be seen that there exists a relationship of correspondence between Huazhuo Jiedu Formula and the pattern of internal accumulation of zhuodu in CAG. And it shows that the key pathogenesis of CAG is internal accumulation of zhuodu, and the corresponding treatment is Huazhuo Jiedu Method.