ABSTRACT
Objective: To simulate the kinematics of drug particles in two kinds of dry powder inhalation devices for Rehmanniae Radix oligosaccharide dry powder inhalation (RRODPI) by computational fluid dynamics (CFD), and to compare simulation results with the in vitro deposition results in order to verify the accuracy of the results. Methods: NGI was used to carry out in vitro deposition experiments, and the relative experiment data were obtained. UGNX 10.0 software was adopted to establish three-dimensional models of two kinds of dry powder inhalation devices according to their actual sizes, and then the models were imported into ICEM CFD software to divide mesh. After checking mesh quality, mesh was imported to Fluent software and the related parameters were set. When the data was in steady state after iteration and convergence, the data analysis was carried out; Finally the kinematics results of drug particles at three kinds of particle sizes in two kinds of dry powder inhalation devices were gained. The kinematics results were compared with the in vitro deposition results to verify the simulation results. Results: In vitro deposition experiment results showed that the effective deposition rate in twister was higher than that in osmohaler. CFD results showed that drug particles at different sizes in twister could all reach the outlet but for drug particles in osmohaler, it could not reach the outlet at a certain range of sizes. The two results showed that twister was more suitable for the dry powder inhaler device of RRODPI. Conclusion: It is comparatively intuitive to use CFD to carry out the kinematics simulation of drug particles in two kinds of dry powder inhalation devices and the result is consistent with the in vitro deposition experiment results, which can well predict the motion state of drug particles in the two dry powder inhalation devices.
ABSTRACT
Objective To analyze and compare in vitro deposition results of budesonide inhalation suspension made by 3 jet nebulizers. Methods Self-made budesonide inhalation suspension was selected as a model drug,and the in vitro deposition proper?ties was determined by breathing simulator and the next generation pharmaceutical impactor(NGI)with Pari Turob BOY N、BOY SX and Omron NE-C28 nebulizers. Results The mass median aerodynamic diameter(MMAD)of aerosol measured with the three kinds of nebulizers ranged between 4.95 and 6.54μm,geometric standard deviation(GSD)ranged between 1.66 and 2.10,fine particle dose (FPD)ranged between 87.64 and 101.47μg and fine particle fraction(FPF)ranged between 37.75%and 53.88%. Delivery rates of Pari Turob BOY N and BOY SX were similar,while the delivery rate of Omron NE-C28 was low. The total delivery of each nebulizer was about 0.11μg. Statistical analysis showed that different nebulizer had no significant difference on delivered dose ,but had signifi?cant difference on delivered rate(P<0.01)and aerodynamic measurement results(P<0.05). Conclusion Different jet nebulizers for budesonide inhalation suspension have certain influence on its in vitro deposition. The suitability of the Omron NE-C28 is the best among the three kinds of nebulizers.
ABSTRACT
Objective To analyze and compare in vitro deposition results of budesonide inhalation suspension made by 3 jet nebulizers. Methods Self-made budesonide inhalation suspension was selected as a model drug, and the in vitro deposition properties was determined by breathing simulator and the next generation pharmaceutical impactor (NGI) with Pari Turob BOY N?BOY SX and Omron NE-C28 nebulizers. Results The mass median aerodynamic diameter (MMAD) of aerosol measured with the three kinds of nebulizers ranged between 4.95 and 6.54 µm, geometric standard deviation(GSD)ranged between 1.66 and 2.10,fine particle dose (FPD) ranged between 87.64 and 101.47 µg and fine particle fraction (FPF) ranged between 37.75% and 53.88%. Delivery rates of Pari Turob BOY N and BOY SX were similar, while the delivery rate of Omron NE-C28 was low. The total delivery of each nebulizer was about 0.11 µg. Statistical analysis showed that different nebulizer had no significant difference on delivered dose, but had significant difference on delivered rate(P<0.01)and aerodynamic measurement results(P<0.05). Conclusion Different jet nebulizers for budesonide inhalation suspension have certain influence on its in vitro deposition. The suitability of the Omron NE-C28 is the best among the three kinds of nebulizers.
ABSTRACT
OBJECTIVE: To study the physicochemical property and stability of zanamivir dry powder inhalation (ZDI). METHODS: ZDI was prepared by spray-drying method. The hygroscopicity, relative humidity, particle size, powder morphology, emptying rate and deposition rate of the inhalation were determined. Water contents were analyzed by TGA. The stability of ZDI was determined by accelerated test and long-term test. RESULTS: The resultant powder inhalation exhibited the following properties: critical relative humidity was 67%, and average aerodynamic diameter dae was 90%, and deposition rate was >30% for thress batches of samples; the accelerated test and the long-term test indicated that zanamivir dry powder inhalation was stable. CONCLUSION: Zanamivir dry powder inhalation is stable and suitable for drug delivery.