ABSTRACT
Objective: To detect the levels of visfatin, prostaglandin E2 (PGE2) and interleukin-lβ (IL-1β) in serum of the chronic periodontitis patients, and to investigate the role of the above three factors in the pathogenesis of chronic periodontitis and their clinical significances in the assessment of activity of chronic periodontitis. Methods: A total of 79 cases of chronic periodontitis patients (including active and resting stages) were selected. The chronic periodontitis patients were divided into active stage of chronic periodontitis group (n=33) and resting stage of chronic periodontitis group (n=46) according to the diagnostic criteria for chronic periodontitis activity. A total of 25 cases of healthy volunteers were also selected as healthy control group. The serum of all cases were collected, then the serum levels of visfatin, PGE2 and IL-1β of the subjects in various groups were detected by ELISA method. The relationships between the serum levels of visfatin, PGE2 and IL-lfi were analyzed with Spearman and partial correlation analysis. Results: The levels of serum visfatin, PGE2 and IL-lfi of the patients in chronic periodontitis group were significantly higher than those in healthy control group (P