ABSTRACT
AIM: To explore the effects and mechanisms of classic prescription Jiajian Yun? Decoction(JJYND) on ventricular remodeling. METHODS: Two kinds of ventricular remodeling model were induced by injecting L-thyroxine intraperitoneally or banding abdominal aorta in rats.The effects of JJYND on heart index(HI) and concentrations of neuroendocrine factors such as serum nitric oxide(NO),myocardium angiotensin Ⅱ(Ang Ⅱ),endothelin-1(ET-1),activities of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),concentration of myocardium hydroxyproline(Hyp),cross section area of cardiomyocyte were determined. RESULTS: JJYND could significantly reduce the heart index,cardiomyocyte cross section area,elevate serum NO concentration,restrain myocardium Ang Ⅱ,ET-1,Hyp concentrations and improve myocardium GSH-Px、SOD activities. CONCLUSION: Prescription JJYND has good effects on attenuating ventricular remodeling.