ABSTRACT
Objective: To observe the effect of Kangqianling Granules (Radix Salviae miltiorrhizae,Radix et Rhizoma Rhei, Radix Achyranthis Bidentatae, etc.) on renal function and renal fibrosis in chronic renal faiure(CRF). Methods: Effect of Kangqianling Granules on Serum Creatinine (SCR), Blood Urea Nitrogen (BUN), Laminin (LN), Fibronectin (FN), Precollagen Ⅲ (PC Ⅲ) and Collagen Ⅳ (C Ⅳ) were observed in CRF patients and rats with 5/6 nephrectomy. The expression of FN and C Ⅳ in remnent renal tissue of model rats were determined by immunhistochemistry. Results: Kangqianling Granules decreased significently serum volume for Scr, BUN, LN, PC Ⅲ, C Ⅳ and elevated FN considerably in CRF patients and rats. Kangqianling Granules inhibited the expressions of FN and C Ⅳ protein in remnant renal tissue of model rats. Conclusion:Kangqianling Granules could relieve renal fibrosis and delay process of CRF.