ABSTRACT
[Objective] To evaluate the therapeutic effect of Buxin Huoluo Capsule (BHC) for coronary heart disease (CHD) and to explore its anti-lipid-peroxidation mechanism. [Methods] One hundred and seventy-five cases of CHD were treated with BHC and 121 cases with isosorbide dinitrate (ID) . Effects of BHC on angina pectoris, electrocardiograph, superoxide dismutase (SOD) activity and lipid peroxides (LPO) level were observed. [Results] In BHC group, the total effective rate in relieving angina pectoris was 88.0 % and that in improving electrocardiogram was 80.0 % , the difference being not significant as compared with ID group. As for the reduction of frequency of angina pectoris and the decrease of dosage of nitroglycerin, BHC were superior to ID. Furthermore, BHC decreased LPO level and increased SOD activity, the difference being significant (P
ABSTRACT
The anti-aging effect of Yang Shou Dan (YSD) was studied. It was shown that YSD could obviously increase the activity of superoxicde dismutase (SOD) in erythrocyte, decrease lipid peroxides (LPO) in serum and in liver tissue and reduce the content of lipofucin in myocardium of mice. It could also prolong the mean life span, the half lethal period and the longest life time of drosophila melanogater. It is suggested that YSD exerts an anti-aging effect to a certain extent.
ABSTRACT
20% TBSA full thickness burns was inflicted on the back of rats with a 5 KW bromotungsten lamp. The animals were sacrificed on the 1st, 2nd, 3rd, 5th, 7th, and 9th day post-burn. Then the lipid peroxide and Vitamin E contents of the plasma, eschar and liver homogenate, mitochondria and microsomes were determined. It was found that the lipid peroxide content of the plasma and eschar increased postburn. The elevation of lipid peroxide level in the escbar showed 2 peaks on the 2nd and 7-9th day postburn and was related to the positive bacterial culture of the sube-schar tissues. The changes of the lipid peroxide levels in the mitochondria and microsomes were similar to those in the eschar. The elevation of plasma lipid peroxide showed only one peak on the 3rd day postburn. The vitamin E levels in these tissues decreased markedly after injury, reached the lowest point 3-5 days after burns, and maintained at a low level throughout the whole course of observation.The causes of the increase of lipid peroxidation and its damage to the subcel-lular structures were briefly discussed.